[1] Z.K. Chang, Z.P. Kou, S.X. Li, X.L. Lou, To evaluate the correlation between the change ofimmune system function before and after the treatment of malignant obstructive type jaundicetreated with biliary stent, Eur. Rev. Med. Pharmacol. Sci. 22(6) (2018) 1638-1644.
[2] J. Sha, Y. Dong, H. Niu, A prospective study of risk factors for in-hospital mortality inpatients with malignant obstructive jaundice undergoing percutaneous biliary drainage,Medicine (Baltimore) 98(15) (2019) e15131.
[3] J.M. Coates, S.H. Beal, J.E. Russo, K.A. Vanderveen, S.L. Chen, R.J. Bold, R.J. Canter,Negligible effect of selective preoperative biliary drainage on perioperative resuscitation,morbidity, and mortality in patients undergoing pancreaticoduodenectomy, Arch. Surg. 144(9)(2009) 841-7.
[4] H. Nishio, M. Nagino, Y. Nimura, Surgical management of hilar cholangiocarcinoma: theNagoya experience, HPB (Oxford) 7(4) (2005) 259-62.
[5] S. Mehrotra, S. Lalwani, S. Nundy, Management Strategies for Patients with HilarCholangiocarcinomas: Challenges and Solutions, Hepat. Med. 12 (2020) 1-13.
[6] H. Moole, M. Bechtold, S.R. Puli, Efficacy of preoperative biliary drainage in malignantobstructive jaundice: a meta-analysis and systematic review, World J. Surg. Oncol. 14(1) (2016)182.
[7] J.D. Wig, H. Kumar, S. Suri, N.M. Gupta, Usefulness of percutaneous transhepatic biliary drainage in patients with surgical jaundice--a prospective randomised study, J. Assoc.Physicians India 47(3) (1999) 271-4.
[8] T. Mizutani, Y. Yokoyama, T. Kokuryo, T. Ebata, T. Igami, G. Sugawara, M. Nagino, Doesinchinkoto, a herbal medicine, have hepatoprotective effects in major hepatectomy? Aprospective randomized study, HPB (Oxford) 17(5) (2015) 461-9.
[9] N. Hashizume, R. Shin, J. Akiba, N. Sotogaku, K. Asagiri, S. Hikida, S. Fukahori, S. Ishii,N. Saikusa, Y. Koga, H. Egami, Y. Tanaka, A. Nishi, M. Yagi, The herbal medicines Inchinkotoand Saireito improved hepatic fibrosis via aquaporin 9 in the liver of a rat bile duct ligationmodel, Pediatr. Surg. Int. (2021).
[10] R.J. Chaudhary, R. Higuchi, M. Nagino, M. Unno, M. Ohtsuka, I. Endo, S. Hirano, K.Uesaka, K. Hasegawa, T. Wakai, S. Uemoto, M. Yamamoto, Survey of preoperativemanagement protocol for perihilar cholangiocarcinoma at 10 Japanese high-volume centerswith a combined experience of 2,778 cases, J. Hepatobiliary Pancreat. Sci. 26(11) (2019) 490-502.
[11] M. Uji, Y. Yokoyama, T. Asahara, T. Ebata, T. Igami, T. Mizuno, J. Yamaguchi, M. Nagino,Does the intestinal microenvironment have an impact on the choleretic effect of inchinkoto, ahepatoprotective herbal medicine?, Hepatol. Res. 48(3) (2018) E303-E310.
[12] R. Nakatake, T. Tsuda, T. Matsuura, H. Miki, H. Hishikawa, H. Matsushima, M. Ishizaki,K. Matsui, M. Kaibori, M. Nishizawa, T. Okumura, M. Kon, Genipin Inhibits the Induction of Inducible Nitric Oxide Synthase Through the Inhibition of NF-kappaB Activation in RatHepatocytes, Drug Metab Lett 10(4) (2017) 254-263.
[13] Y. Yokoyama, M. Nagino, Current scenario for the hepatoprotective effects of Inchinkoto,a traditional herbal medicine, and its clinical application in liver surgery: A review, Hepatol.Res. 44(4) (2014) 384-94.
[14] Y. Yokoyama, T. Kokuryo, K. Kawai, T. Mizutani, S. Watanabe, M. Nagino, [Beneficialeffects of preoperative administration of Inchinkoto in patients undergoing major hepatectomy],Nihon Geka Gakkai Zasshi 114(5) (2013) 256-60.
[15] T. Matsuura, M. Kaibori, Y. Araki, M. Matsumiya, Y. Yamamoto, Y. Ikeya, M. Nishizawa,T. Okumura, A.H. Kwon, Japanese herbal medicine, inchinkoto, inhibits inducible nitric oxidesynthase induction in interleukin-1beta-stimulated hepatocytes, Hepatol. Res. 42(1) (2012) 76-90.
[16] A. Mase, B. Makino, N. Tsuchiya, M. Yamamoto, Y. Kase, S. Takeda, T. Hasegawa, Activeingredients of traditional Japanese (kampo) medicine, inchinkoto, in murine concanavalin A452 induced hepatitis, J. Ethnopharmacol. 127(3) (2010) 742-9.
[17] K. Kawai, Y. Yokoyama, T. Kokuryo, K. Watanabe, T. Kitagawa, M. Nagino, Inchinkoto,an herbal medicine, exerts beneficial effects in the rat liver under stress with hepatic ischemia455 reperfusion and subsequent hepatectomy, Ann. Surg. 251(4) (2010)700.
[18] S. Watanabe, Y. Yokoyama, K. Oda, T. Kokuryo, J. Shoda, K. Okada, H. Utsunomiya, MNagino, Choleretic effect of inchinkoto, a herbal medicine, on livers of patients with biliaryobstruction due to bile duct carcinoma, Hepatol. Res. 39(3) (2009) 247-55.
[19] K. Okada, J. Shoda, M. Kano, S. Suzuki, Noho. Ohtake, M. Yamamoto, H. Takahashi, H.Utsunomiya, K. Oda, K. Sato, A. Watanabe, T. Ishii, K. Itoh, M. Yamamoto, T. Yokoi, K.Yoshizato, Y. Sugiyama, H. Suzuki, Inchinkoto, a herbal medicine, and its ingredients duallyexert Mrp2/MRP2-mediated choleresis and Nrf2-mediated antioxidative action in rat livers, Am.J. Physiol. Gastrointest. Liver Physiol. 292(5) (2007) G1450-63.
[20] J. Shoda, T. Miura, H. Utsunomiya, K. Oda, M. Yamamoto, M. Kano, T. Ikegami, N.Tanaka, H. Akita, K. Ito, H. Suzuki, Y. Sugiyama, Genipin enhances Mrp2 (Abcc2)-mediatedbile formation and organic anion transport in rat liver, Hepatology 39(1) (2004) 167-78.
[21] M. Uji, Y. Yokoyama, K. oh, K. Tsuchiya, C. Sadakane, C. Shimobori, M. Yamamoto, M.Nagino, Exploration of serum biomarkers for predicting the response to Inchinkoto (ICKT), aJapanese traditional herbal medicine, Metabolomics 13(12) (2017) 155.
[22] M. Yamamoto, N. Miura, N. Ohtake, S. Amagaya, A. Ishige, H. Sasaki, Y. Komatsu, K.Fukuda, T. Ito, K. Terasawa, Genipin, a metabolite derived from the herbal medicine Inchin472 ko-to, and suppression of Fas-induced lethal liver apoptosis in mice,roenterology 118(2)(2000) 380-9.
[23] S. Schloissnig, M. Arumugam, S. Sunagawa, M. Mitreva, J. Tap, A. Zhu, A. Waller, D.R.Mende, J.R. Kultima, J. Martin, K. Kota, S.R. Sunyaev, G.M. Weinstock, P. Bork, Genomic variation landscape of the human gut microbiome, Nature 493(7430) (2013) 45-50.
[24] J. Qin, R. Li, J. Raes, M. Arumugam, K.S. Burgdorf, C. Manichanh, T. Nielsen, N. Pons,F. Levenez, T. Yamada, D.R. Mende, J. Li, J. Xu, S. Li, D. Li, J. Cao, B. Wang, H. Liang, H.Zheng, Y. Xie, J. Tap, P. Lepage, M. Bertalan, J.M. Batto, T. Hansen, D. Le Paslier, A. Linneberg,H.B. Nielsen, E. Pelletier, P. Renault, T. Sicheritz-Ponten, K. Turner, H. Zhu, C. Yu, S. Li, M.Jian, Y. Zhou, Y. Li, X. Zhang, S. Li, N. Qin, H. Yang, J. Wang, S. Brunak, J. Doré, F. Guarner,K. Kristiansen, O. Pedersen, J. Parkhill, J. Weissenbach, P. Bork, S.D. Ehrlich, J. Wang, Ahuman gut microbial gene catalogue established by metagenomic sequencing, Nature464(7285) (2010) 59-65.
[25] S. Nishijima, W. Suda, K. Oshima, S.W. Kim, Y. Hirose, H. Morita, M. Hattori, The gutmicrobiome of healthy Japanese and its microbial and functional uniqueness, DNA Res. 23(2)(2016) 125-33.
[26] H. Yamashita, K. Ohbuchi, M. Nagino, T. Ebata, K. Tsuchiya, H. Kushida, Y. Yokoyama,Comprehensive metabolome analysis for the pharmacological action of inchinkoto, ahepatoprotective herbal medicine, Metabolomics (2021) in press.
[27] K.W. Heaton, J. Radvan, H. Cripps, R.A. Mountford, F.E. Braddon, A.O. Hughes,Defecation frequency and timing, and stool form in the general population: a prospective study,Gut 33(6) (1992) 818-24.
[28] Y. Furusawa, Y. Obata, S. Fukuda, T.A. Endo, G. Nakato, D. Takahashi, Y. Nakanishi, C. Uetake, K. Kato, T. Kato, M. Takahashi, N.N. Fukuda, S. Murakami, E. Miyauchi, S. Hino, K.Atarashi, S. Onawa, Y. Fujimura, T. Lockett, J.M. Clarke, D.L. Topping, M. Tomita, S. Hori, O.Ohara, T. Morita, H. Koseki, J. Kikuchi, K. Honda, K. Hase, H. Ohno, Commensal microbe498 derived butyrate induces the differentiation of colonic regulatory T cells,re 504(7480)(2013) 446-50.
[29] J.G. Caporaso, J. Kuczynski, J. Stombaugh, K. Bittinger, F.D. Bushman, E.K. Costello, N.Fierer, A.G. Pena, J.K. Goodrich, J.I. Gordon, G.A. Huttley, S.T. Kelley, D. Knights, J.E.Koenig, R.E. Ley, C.A. Lozupone, D. McDonald, B.D. Muegge, M. Pirrung, J. Reeder, J.R.Sevinsky, P.J. Turnbaugh, W.A. Walters, J. Widmann, T. Yatsunenko, J. Zaneveld, R. Knight,QIIME allows analysis of high-throughput community sequencing data, Nat. Methods 7(5)(2010) 335-6.
[30] T. Hasebe, N. Ueno, M.W. Musch, A. Nadimpalli, A. Kaneko, N. Kaifuchi, J. Watanabe,M. Yamamoto, T. Kono, Y. Inaba, M. Fujiya, Y. Kohgo, E.B. Chang, Daikenchuto (TU-100)shapes gut microbiota architecture and increases the production of ginsenoside metabolitecompound K, Pharmacol Res Perspect 4(1) (2016) e00215.
[31] E. Takeo, R. Sasano, S. Shimma, T. Bamba, E. Fukusaki, Solid-phase analyticalderivatization for gas-chromatography-mass-spectrometry-based metabolomics, J. Biosci.Bioeng. 124(6) (2017) 700-706.
[32] I.F. Spellerberg, P.J. Fedor, A tribute to Claude Shannon (1916–2001) and a plea for more rigorous use of species richness, species diversity and the ‘Shannon–Wiener’Index., Glob EcolBiogeogr. 12(3) (2003) 177-179.
[33] C.E. Shannon, A mathematical theory of communication. , The Bell System TechnicalJournal 27 (1948) 379–423 and 623–656.
[34] Jari Oksanen, F. Guillaume Blanchet, Michael Friendly, Roeland Kindt, Pierre Legendre,Dan McGlinn, Peter R. Minchin, R. B. O'Hara, Gavin L. Simpson, Peter Solymos, M. HenryH. Stevens, Eduard Szoecs, H. Wagner, vegan: Community Ecology Package, R packageversion 2.5-4., (2019).
[35] J. Friedman, E.J. Alm, Inferring correlation networks from genomic survey data, PLoSComput. Biol. 8(9) (2012) e1002687.
[36] J. Chong, P. Liu, G. Zhou, J. Xia, Using MicrobiomeAnalyst for comprehensive statistical,functional, and meta-analysis of microbiome data, Nat. Protoc. 15(3) (2020) 799-821.
[37] M.J. Kang, T. Khanal, H.G. Kim, D.H. Lee, H.K. Yeo, Y.S. Lee, Y.T. Ahn, D.H. Kim, H.G.Jeong, T.C. Jeong, Role of metabolism by human intestinal microflora in geniposide-inducedtoxicity in HepG2 cells, Arch. Pharm. Res. 35(4) (2012) 733-8.
[38] P.B. Eckburg, E.M. Bik, C.N. Bernstein, E. Purdom, L. Dethlefsen, M. Sargent, S.R. Gill,K.E. Nelson, D.A. Relman, Diversity of the human intestinal microbial flora, Science308(5728) (2005) 1635-8.
[39] F. Qin, H. Wu, X. Li, J. Han, Correlation between changes in gut flora and seruminflammatory factors in children with noninfectious diarrhea, J. Int. Med. Res. 48(1) (2020)300060519896154.
[40] M.S. Mortensen, B. Hebbelstrup Jensen, J. Williams, A.D. Brejnrod, L. O'Brien Andersen,D. Roser, B.U. Andreassen, A.M. Petersen, C.R. Stensvold, S.J. Sorensen, K.A. Krogfelt,Stability and resilience of the intestinal microbiota in children in daycare - a 12 month cohortstudy, BMC Microbiol. 18(1) (2018) 223.
[41] A. Wang, Z. Ling, Z. Yang, P.R. Kiela, T. Wang, C. Wang, L. Cao, F. Geng, M. Shen, X.Ran, Y. Su, T. Cheng, J. Wang, Gut microbial dysbiosis may predict diarrhea and fatigue inpatients undergoing pelvic cancer radiotherapy: a pilot study, PLoS One 10(5) (2015) e0126312.
[42] J. Connors, N. Dawe, J. Van Limbergen, The Role of Succinate in the Regulation ofIntestinal Inflammation, Nutrients 11(1) (2018).
[43] S. Yuille, N. Reichardt, S. Panda, H. Dunbar, I.E. Mulder, Human gut bacteria as potentclass I histone deacetylase inhibitors in vitro through production of butyric acid and valeric acid,PLoS One 13(7) (2018) e0201073.
[44] M. Luu, S. Pautz, V. Kohl, R. Singh, R. Romero, S. Lucas, J. Hofmann, H. Raifer, N.Vachharajani, L.C. Carrascosa, B. Lamp, A. Nist, T. Stiewe, Y. Shaul, T. Adhikary, M.M. Zaiss,M. Lauth, U. Steinhoff, A. Visekruna, The short-chain fatty acid pentanoate suppressesautoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes, Nat Commun10(1) (2019) 760.
[45] Y. Li, J. Dong, H. Xiao, S. Zhang, B. Wang, M. Cui, S. Fan, Gut commensal derived553 valeric acid protects against radiation injuries, Gut Microbes 11(4) (2020)806.
[46] E. van Nood, A. Vrieze, M. Nieuwdorp, S. Fuentes, E.G. Zoetendal, W.M. de Vos, C.E.Visser, E.J. Kuijper, J.F. Bartelsman, J.G. Tijssen, P. Speelman, M.G. Dijkgraaf, J.J. Keller,Duodenal infusion of donor feces for recurrent Clostridium difficile, N. Engl. J. Med. 368(5)(2013) 407-15.
[47] Y. Yokoyama, T. Miyake, T. Kokuryo, T. Asahara, K. Nomoto, M. Nagino, Effect ofPerioperative Synbiotic Treatment on Bacterial Translocation and Postoperative InfectiousComplications after Pancreatoduodenectomy, Dig. Surg. 33(3) (2016) 220-9.
[48] Y. Yokoyama, E. Nishigaki, T. Abe, M. Fukaya, T. Asahara, K. Nomoto, M. Nagino,Randomized clinical trial of the effect of perioperative synbiotics versus no synbiotics onbacterial translocation after oesophagectomy, Br. J. Surg. 101(3) (2014) 18