Biochemical markers to predict the development of gastrointestinal bleeding and esophageal varices after portoenterostomy in biliary atresia

概要

Purpose: Gastrointestinal bleeding (GIB) due to esophageal varices (EV) is one of the factors that
negatively impacts native liver survival of patients with biliary atresia (BA). Gastrointestinal fibroscopy
(GIF) is usually used to determine the presence of EVs; however, it require general anesthesia. The aim of
this study is to search for markers in blood tests obtained during routine check-ups that can predict the
development of GIB.
Methods: Data of patients with BA who underwent portoenterostomy at our hospital from 2014 to 2020
were retrospectively reviewed. The patients’ data were assigned to three groups according to specific time
points: Group B, which included data at GIB; Group NB-T, which included data at GIF and EV treatment;
and Group NB-NT, which included data at GIF without treatment. The data in Group B were compared to
those of other groups.
Results: In our study, GIB occurred in 11 patients, and 12 cases, and 8 cases were classified into Groups
NB-NT and NB-T, respectively. Compared with the other groups, only ChE and M2BPGi in Group B
showed statistically significant differences.
Conclusions: ChE and M2BPGi are useful for predicting GIB. ...

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