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Pilot study to estimate the safety and effectiveness of hydroxyurea and methotrexate recurrent langerhans cell histiocytosis (LCH-HU-pilot)

SAKAMOTO Kenichi 0000-0003-1499-538X KIKUCHI Kayoko SAKO Mayumi KATO Miho TAKIMOTO Tetsuya SHIODA Yoko 30307532 滋賀医科大学 DOI:10.1097/md.0000000000031475

2022.12.16

概要

This study was a non-blinded, multicenter, single-arm study. Recurrent (relapsed) LCH is defined as the appearance of new lesions or the enlargement of preexisting lesions due to LCH. In this study, all patients received hydroxyurea, and if the treatment response was unsatisfactory, methotrexate was added. The duration of treatment was 48 weeks. The primary endpoint was the rate of non-active disease achievement, which was 24 weeks after initiating hydroxyurea administration. No active disease is defined as the resolution of all the signs and symptoms related to LCH.

参考文献

[1] Emile JF, Abla O, Fraitag S, et al. Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages. Blood. 2016;127:2672–81.

[2] Morimoto A, Oh Y, Shioda Y, et al. Recent advances in langerhans cell histiocytosis. Pediatr Int. 2014;56:451–61.

[3] Berres ML, Merad M, Allen CE. Progress in understanding the pathogenesis of langerhans cell histiocytosis: back to histiocytosis X?. Br J Haematol. 2015;169:3–13.

[4] Gadner H, Grois N, Arico M, et al. A randomized trial of treatment for multisystem langerhans’ cell histiocytosis. J Pediatr. 2001;138:728–34.

[5] Gadner H, Grois N, Pötschger U, et al. Improved outcome in multisystem Langerhans cell histiocytosis is associated with therapy intensification. Blood. 2008;111:2556–62.

[6] Gadner H, Minkov M, Grois N, et al. Therapy prolongation improves outcome in multisystem Langerhans cell histiocytosis. Blood. 2013;121:5006–14.

[7] Morimoto A, Ikushima S, Kinugawa N, et al. Improved outcome in the treatment of pediatric multifocal langerhans cell histiocytosis: results from the Japan Langerhans cell histiocytosis study group-96 protocol study. Cancer. 2006;107:613–9.

[8] Morimoto A, Shioda Y, Imamura T, et al. Intensified and prolonged therapy comprising cytarabine, vincristine and prednisolone improves outcome in patients with multisystem langerhans cell histiocytosis: results of the Japan langerhans cell histiocytosis study group-02 protocol study. Int J Hematol. 2016;104:99–109.

[9] Morimoto A, Shioda Y, Imamura T, et al. Intensification of induction therapy and prolongation of maintenance therapy did not improve the outcome of pediatric langerhans cell histiocytosis with single-system multifocal bone lesions: results of the Japan langerhans cell histiocytosis study group-02 protocol study. Int J Hematol. 2018;108:192–8.

[10] Minkov M, Steiner M, Pötschger U, et al. Reactivations in multisystem langerhans cell histiocytosis: data of the international LCH registry. J Pediatr 2008;153:700–5, 705.e1, 705:e701–e702.

[11] Sakamoto K, Morimoto A, Shioda Y, et al. Central diabetes insipidus in pediatric patients with langerhans cell histiocytosis: results from the JLSG-96/02 studies. Pediatr Blood Cancer. 2018:e27454.

[12] Sakamoto K, Morimoto A, Shioda Y, et al. Long-term complications in uniformly treated paediatric langerhans histiocytosis patients disclosed by 12 years of follow-up of the JLSG-96/02 studies. Br J Haematol. 2021;192:615–20.

[13] Zinn DJ, Grimes AB, Lin H, et al. Hydroxyurea: a new old therapy for langerhans cell histiocytosis. Blood. 2016;128:2462–5.

[14] Morimoto A, Shioda Y, Imamura T, et al. Nationwide survey of bisphosphonate therapy for children with reactivated langerhans cell histiocytosis in Japan. Pediatr Blood Cancer. 2011;56:110–5.

[15] De Benedittis D, Mohamed S, Rizzo L, et al. Indomethacin is an effective treatment in adults and children with bone langerhans cell histiocytosis (LCH). Br J Haematol. 2020;191:e109–13.

[16] Taniguchi M, Sakamoto K, Shioda Y, et al. Salvage therapy with 2-chlorodeoxyadenosine for refractory and relapsed pediatric langerhans cell histiocytosis: an updated nationwide survey in Japan. Int J Hematol. 2021;113:461–3.

[17] Simko SJ, Tran HD, Jones J, et al. Clofarabine salvage therapy in refractory multifocal histiocytic disorders, including langerhans cell histiocytosis, juvenile xanthogranuloma and rosai-dorfman disease. Pediatr Blood Cancer. 2014;61:479–87.

[18] Hankins JS, Ware RE, Rogers ZR, et al. Long-term hydroxyurea therapy for infants with sickle cell anemia: the HUSOFT extension study. Blood. 2005;106:2269–75.

[19] Wang WC, Helms RW, Lynn HS, et al. Effect of hydroxyurea on growth in children with sickle cell anemia: results of the HUG-KIDS study. J Pediatr. 2002;140:225–9.

[20] Joseph L, Jean C, Manceau S, et al. Effect of hydroxyurea exposure before puberty on sperm parameters in males with sickle cell disease. Blood. 2021;137:826–9.

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