Asai, S., Otsuru, S., Candela, M. E., Cantley, L., Uchibe, K., Hofmann, T. J., et al. (2014). Tendon Progenitor Cells in Injured Tendons Have Strong Chondrogenic Potential: The CD105-Negative Subpopulation Induces Chondrogenic Degeneration. Stem Cells 32, 3266–3277. doi:10.1002/stem.1847
Ateschrang, A., Gratzer, C., and Weise, K. (2007). Incidence and Effect of Calcifications after Open-Augmented Achilles Tendon Repair. Arch. Orthop. Trauma Surg. 128, 1087–1092. doi:10.1007/s00402-007-0441-5
Bernstein, E., Kim, S. Y., Carmell, M. A., Murchison, E. P., Alcorn, H., Li, M. Z., et al. (2003). Dicer Is Essential for Mouse Development. Nat. Genet. 35, 215–217. doi:10.1038/ng1253
Bi, Y., Ehirchiou, D., Kilts, T. M., Inkson, C. A., Embree, M. C., Sonoyama, W., et al. (2007). Identification of Tendon Stem/progenitor Cells and the Role of the Extracellular Matrix in Their Niche. Nat. Med. 13, 1219–1227. doi:10.1038/ nm1630
Burger, K., Schlackow, M., Potts, M., Hester, S., Mohammed, S., and Gullerova, M. (2017). Nuclear Phosphorylated Dicer Processes Double-Stranded RNA in Response to DNA Damage. J. Cell Biol. 216, 2373–2389. doi:10.1083/jcb. 201612131
Chen, L., Wang, G.-D., Liu, J.-P., Wang, H.-S., Liu, X.-M., Wang, Q., et al. (2015). miR-135a Modulates Tendon Stem/progenitor Cell Senescence via Suppressing ROCK1. Bone 71, 210–216. doi:10.1016/j.bone.2014.11.001
Cheung, T. H., Quach, N. L., Charville, G. W., Liu, L., Park, L., Edalati, A., et al. (2012). Maintenance of Muscle Stem-Cell Quiescence by microRNA-489. Nature 482, 524–528. doi:10.1038/nature10834
De Micheli, A. J., Swanson, J. B., Disser, N. P., Martinez, L. M., Walker, N. R., Oliver, D. J., et al. (2020). Single-cell Transcriptomic Analysis Identifies Extensive Heterogeneity in the Cellular Composition of Mouse Achilles Tendons. Am. J. Physiology-Cell Physiology 319, C885–C894. doi:10.1152/ ajpcell.00372.2020
Delgado Caceres, M., Pfeifer, C. G., and Docheva, D. (2018). Understanding Tendons: Lessons from Transgenic Mouse Models. Stem Cells Dev. 27, 1161–1174. doi:10.1089/scd.2018.0121
Disser, N. P., Ghahramani, G. C., Swanson, J. B., Wada, S., Chao, M. L., Rodeo, S. A., et al. (2020). Widespread Diversity in the Transcriptomes of Functionally Divergent Limb Tendons. J. Physiol. 598, 1537–1550. doi:10.1113/JP279646
Docheva, D., Hunziker, E. B., Fa€ssler, R., and Brandau, O. (2005). Tenomodulin Is Necessary for Tenocyte Proliferation and Tendon Maturation. Mol. Cell Biol. 25, 699–705. doi:10.1128/mcb.25.2.699-705.2005
Donoghue, O. A., Harrison, A. J., Laxton, P., and Jones, R. K. (2008). Lower Limb Kinematics of Subjects with Chronic Achilles Tendon Injury during Running. Res. Sports Med. 16, 23–38. doi:10.1080/15438620701693231
Dubin, J. A., Greenberg, D. R., Iglinski-Benjamin, K. C., and Abrams, G. D. (2018). Effect of Micro-RNA on Tenocytes and Tendon-Related Gene Expression: A Systematic Review. J. Orthop. Res. 36, 2823–2829. doi:10. 1002/jor.24064
Gaur, T., Hussain, S., Mudhasani, R., Parulkar, I., Colby, J. L., Frederick, D., et al. (2010). Dicer Inactivation in Osteoprogenitor Cells Compromises Fetal Survival and Bone Formation, while Excision in Differentiated Osteoblasts Increases Bone Mass in the Adult Mouse. Dev. Biol. 340, 10–21. doi:10.1016/j. ydbio.2010.01.008
Gaut, L., Robert, N., Delalande, A., Bonnin, M.-A., Pichon, C., and Duprez, D. (2016). EGR1 Regulates Transcription Downstream of Mechanical Signals during Tendon Formation and Healing. PLOS ONE 11, e0166237. doi:10. 1371/journal.pone.0166237
Guerquin, M.-J., Charvet, B., Nourissat, G., Havis, E., Ronsin, O., Bonnin, M.- A., et al. (2013). Transcription Factor EGR1 Directs Tendon Differentiation and Promotes Tendon Repair. J. Clin. Invest. 123, 3564–3576. doi:10.1172/ jci67521
Gumucio, J. P., Schonk, M. M., Kharaz, Y. A., Comerford, E., and Mendias, C. L. (2020). Scleraxis Is Required for the Growth of Adult Tendons in Response to Mechanical Loading. JCI insight 5, 138295. doi:10.1172/jci.insight.138295
Guo, W.-T., and Wang, Y. (2019). Dgcr8 Knockout Approaches to Understand microRNA Functions In Vitro and In Vivo. Cell. Mol. Life Sci. 76, 1697–1711. doi:10.1007/s00018-019-03020-9
Harfe, B. D., McManus, M. T., Mansfield, J. H., Hornstein, E., and Tabin, C. J. (2005). The RNaseIII Enzyme Dicer Is Required for Morphogenesis but Not Patterning of the Vertebrate Limb. Proc. Natl. Acad. Sci. U.S.A. 102, 10898–10903. doi:10.1073/pnas.0504834102
Harvey, T., Flamenco, S., and Fan, C.-M. (2019). A Tppp3+Pdgfra+ Tendon Stem Cell Population Contributes to Regeneration and Reveals a Shared Role for PDGF Signalling in Regeneration and Fibrosis. Nat. Cell Biol. 21, 1490–1503. doi:10.1038/s41556-019-0417-z
Hayashi, Y., Yimiti, D., Sanada, Y., Ding, C., Omoto, T., Ogura, T., et al. (2022). The Therapeutic Capacity of Bone Marrow MSC-derived Extracellular Vesicles in Achilles Tendon Healing Is Passage-dependent and Indicated by Specific Glycans. FEBS Lett. 596, 1047–1058. doi:10.1002/1873-3468.14333
Huang, Z., Yin, Z., Xu, J., Fei, Y., Heng, B. C., Jiang, X., et al. (2021). Tendon Stem/ Progenitor Cell Subpopulations and Their Implications in Tendon Biology. Front. Cell Dev. Biol. 9, 631272. doi:10.3389/fcell.2021.631272
Huttunen, T. T., Kannus, P., Rolf, C., Felländer-Tsai, L., and Mattila, V. M. (2014). Acute Achilles Tendon Ruptures. Am. J. Sports Med. 42, 2419–2423. doi:10. 1177/0363546514540599
Ito, Y., Toriuchi, N., Yoshitaka, T., Ueno-Kudoh, H., Sato, T., Yokoyama, S., et al. (2010). The Mohawk Homeobox Gene Is a Critical Regulator of Tendon Differentiation. Proc. Natl. Acad. Sci. U.S.A. 107, 10538–10542. doi:10.1073/pnas.1000525107
Kanellopoulou, C., Muljo, S. A., Kung, A. L., Ganesan, S., Drapkin, R., Jenuwein, T., et al. (2005). Dicer-deficient Mouse Embryonic Stem Cells Are Defective in Differentiation and Centromeric Silencing. Genes Dev. 19, 489–501. doi:10. 1101/gad.1248505
Kim, K., Baek, S. C., Lee, Y.-Y., Bastiaanssen, C., Kim, J., Kim, H., et al. (2021). A Quantitative Map of Human Primary microRNA Processing Sites. Mol. Cell 81, 3422–3439. doi:10.1016/j.molcel.2021.07.002
Kim, Y.-K., Kim, B., and Kim, V. N. (2016). Re-evaluation of the Roles of DROSHA, Exportin 5 , and DICER in microRNA Biogenesis. Proc. Natl. Acad. Sci. U.S.A. 113, E1881–E1889. doi:10.1073/pnas.1602532113
Kobayashi, T., Lu, J., Cobb, B. S., Rodda, S. J., McMahon, A. P., Schipani, E., et al. (2008). Dicer-dependent Pathways Regulate Chondrocyte Proliferation and Differentiation. Proc. Natl. Acad. Sci. U.S.A. 105, 1949–1954. doi:10.1073/pnas.0707900105
Kobayashi, T., Papaioannou, G., Mirzamohammadi, F., Kozhemyakina, E., Zhang, M., Blelloch, R., et al. (2015). Early Postnatal Ablation of the microRNA- Processing Enzyme, Drosha, Causes Chondrocyte Death and Impairs the Structural Integrity of the Articular Cartilage. Osteoarthr. Cartil. 23, 1214–1220. doi:10.1016/j.joca.2015.02.015
La Rocca, G., King, B., Shui, B., Li, X., Zhang, M., Akat, K. M., et al. (2021). Inducible and Reversible Inhibition of miRNA-Mediated Gene Repression In Vivo. eLife 10, e70948. doi:10.7554/elife.70948
Lee, Y., Ahn, C., Han, J., Choi, H., Kim, J., Yim, J., et al. (2003). The Nuclear RNase III Drosha Initiates microRNA Processing. Nature 425, 415–419. doi:10.1038/ nature01957
Lejard, V., Blais, F., Guerquin, M.-J., Bonnet, A., Bonnin, M.-A., Havis, E., et al. (2011). EGR1 and EGR2 Involvement in Vertebrate Tendon Differentiation. J. Biol. Chem. 286, 5855–5867. doi:10.1074/jbc.M110.153106
Michlewski, G., and Cáceres, J. F. (2018). Post-transcriptional Control of miRNA Biogenesis. RNA 25, 1–16. doi:10.1261/rna.068692.118
Miyaki, S., Nakasa, T., Otsuki, S., Grogan, S. P., Higashiyama, R., Inoue, A., et al. (2009). MicroRNA-140 Is Expressed in Differentiated Human Articular Chondrocytes and Modulates Interleukin-1 Responses. Arthritis Rheum. 60, 2723–2730. doi:10.1002/art.24745
Miyaki, S., Sato, T., Inoue, A., Otsuki, S., Ito, Y., Yokoyama, S., et al. (2010). MicroRNA-140 Plays Dual Roles in Both Cartilage Development and Homeostasis. Genes Dev. 24, 1173–1185. doi:10.1101/gad.1915510
Mizoguchi, F., Izu, Y., Hayata, T., Hemmi, H., Nakashima, K., Nakamura, T., et al. (2009). Osteoclast-specific Dicer Gene Deficiency Suppresses Osteoclastic Bone Resorption. J. Cell. Biochem. 109, 866–875. doi:10. 1002/jcb.22228
Murchison, N. D., Price, B. A., Conner, D. A., Keene, D. R., Olson, E. N., Tabin, C. J., et al. (2007). Regulation of Tendon Differentiation by Scleraxis Distinguishes Force-Transmitting Tendons from Muscle-Anchoring Tendons. Dev. Camb. Engl. 134, 2697–2708. doi:10.1242/dev.001933
O’Rourke, J. R., Georges, S. A., Seay, H. R., Tapscott, S. J., McManus, M. T., Goldhamer, D. J., et al. (2007). Essential Role for Dicer during Skeletal Muscle Development. Dev. Biol. 311, 359–368. doi:10.1016/j.ydbio.2007. 08.032
Oikawa, S., Lee, M., and Akimoto, T. (2019a). Conditional Deletion of Dicer in Adult Mice Impairs Skeletal Muscle Regeneration. Ijms 20, 5686. doi:10.3390/ ijms20225686
Oikawa, S., Lee, M., Motohashi, N., Maeda, S., and Akimoto, T. (2019b). An Inducible Knockout of Dicer in Adult Mice Does Not Affect Endurance Exercise-Induced Muscle Adaptation. Am. J. Physiology-Cell PhysiologyCell Physiology 316, C285–C292. doi:10.1152/ajpcell.00278.2018
O’Toole, S. M., Ferrer, M. M., Mekonnen, J., Zhang, H., Shima, Y., Ladle, D. R., et al. (2017). Dicer Maintains the Identity and Function of Proprioceptive Sensory Neurons. J. Neurophysiology 117, 1057–1069. doi:10.1152/jn.00763. 2016
Pong, S. K., and Gullerova, M. (2018). Noncanonical Functions of Micro RNA Pathway Enzymes - Drosha, DGCR 8, Dicer and Ago Proteins. FEBS Lett. 592, 2973–2986. doi:10.1002/1873-3468.13196
Pryce, B. A., Brent, A. E., Murchison, N. D., Tabin, C. J., and Schweitzer, R. (2007). Generation of Transgenic Tendon Reporters, ScxGFP and ScxAP, Using Regulatory Elements of the Scleraxis Gene. Dev. Dyn. 236, 1677–1682. doi:10.1002/dvdy.21179
Starborg, T., Kalson, N. S., Lu, Y., Mironov, A., Cootes, T. F., Holmes, D. F., et al. (2013). Using Transmission Electron Microscopy and 3View to Determine Collagen Fibril Size and Three-Dimensional Organization. Nat. Protoc. 8, 1433–1448. doi:10.1038/nprot.2013.086
Staverosky, J. A., Pryce, B. A., Watson, S. S., and Schweitzer, R. (2009). Tubulin Polymerization-Promoting Protein Family Member 3, Tppp3, Is a Specific Marker of the Differentiating Tendon Sheath and Synovial Joints. Dev. Dyn. 238, 685–692. doi:10.1002/dvdy.21865
Stoll, C., John, T., Conrad, C., Lohan, A., Hondke, S., Ertel, W., et al. (2011). Healing Parameters in a Rabbit Partial Tendon Defect Following Tenocyte/ biomaterial Implantation. Biomaterials 32, 4806–4815. doi:10.1016/j. biomaterials.2011.03.026
Sugimoto, Y., Takimoto, A., Hiraki, Y., and Shukunami, C. (2013). Generation and Characterization ofScxCretransgenic Mice. genesis 51, 275–283. doi:10.1002/ dvg.22372
Vechetti, I. J., Wen, Y., Chaillou, T., Murach, K. A., Alimov, A. P., Figueiredo, V. C., et al. (2019). Life-long Reduction in myomiR Expression Does Not Adversely Affect Skeletal Muscle Morphology. Sci. Rep. 9, 5483. doi:10.1038/s41598-019- 41476-8
Yoshimoto, Y., Takimoto, A., Watanabe, H., Hiraki, Y., Kondoh, G., and Shukunami, C. (2017). Scleraxis Is Required for Maturation of Tissue Domains for Proper Integration of the Musculoskeletal System. Sci. Rep. 7, 45010. doi:10.1038/srep45010
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