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Brain-transportable soy dipeptide, Tyr-Pro, attenuates amyloid β peptide_25-35-induced memory impairment in mice

Tanaka, Mitsuru 田中, 充 タナカ, ミツル Kiyohara, Hayato 清原, 隼人 キヨハラ, ハヤト Yoshino, Atsuko 芳野, 温子 ヨシノ, アツコ Nakano, Akihiro 中野, 明裕 ナカノ, アキヒロ Takata, Fuyuko 高田, 芙友子 タカタ, フユコ Dohgu, Shinya 道具, 伸也 ドウグ, シンヤ Kataoka, Yasufumi 片岡, 泰文 カタオカ, ヤスフミ Matsui, Toshiro 松井, 利郎 マツイ, トシロウ 九州大学

2020.05.01

概要

In this study, experiments on amyloid β peptide25-35-induced mice were performed to provide in vivo evidence on the potential of the blood–brain barrier transportable soy dipeptide, Tyr-Pro, in combat

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ACKNOWLEDGEMENTS

The authors thank Ms Kaori Miyazaki at Kyushu University for technical assistance.

AUTHOR CONTRIBUTIONS

M.T. and T.M. designed this study. H.K., A.Y., A.N., F.T. and S.D. performed all the

analytical experiments and analysed the results. M.T., H.K., A.Y., A.N. and T.M. wrote

the paper. All authors considered and discussed the results and designed whole

experimental strategy. Y.K. commented on the paper. T.M. edited the paper and

supervised the whole project. All the authors have read and approved the final paper.

COMPETING INTERESTS

The authors declare no competing interests.

ADDITIONAL INFORMATION

Supplementary information is available for this paper at https://doi.org/10.1038/

s41538-020-0067-3.

Correspondence and requests for materials should be addressed to T.M.

Reprints and permission information is available at http://www.nature.com/

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© The Author(s) 2020

npj Science of Food (2020) 7

Published in partnership with Beijing Technology and Business University

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