1. Engelmann B, Massberg S. Thrombosis as an intravascular effector of innate immunity. Nat Rev Immunol. 2013;13(1):34-45.
2. Iba T, Levi M, Levy JH. Sepsis-induced coagulopathy and disseminated intravascular coagulation. Semin Thromb Hemost.
2020;46(1):89-95.
3. Ito T, Thachil J, Asakura H, Levy JH, Iba T. Thrombomodulin in
disseminated intravascular coagulation and other critical
conditions-a multi-faceted anticoagulant protein with therapeutic
potential. Crit Care. 2019;23(1):280.
4. Wiedermann CJ. Clinical review: molecular mechanisms underlying the role of antithrombin in sepsis. Crit Care. 2006;10(1):209.
5. Mazzeffi M, Chow JH, Amoroso A, et al. Revisiting the protein C
pathway: an opportunity for adjunctive intervention in
COVID-19? Anesth Analg. 2020;131(3):690-693.
6. Ito T, Kakuuchi M, Maruyama I. Endotheliopathy in septic conditions: mechanistic insight into intravascular coagulation. Crit
Care. 2021;25(1):95.
7. Tagami T, Matsui H, Horiguchi H, et al. Antithrombin and mortality
in severe pneumonia patients with sepsis-associated disseminated
10
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
19.
20.
21.
Clinical and Applied Thrombosis/Hemostasis
intravascular coagulation: an observational nationwide study. J
Thromb Haemost. 2014;12(9):1470-1479.
Tagami T, Matsui H, Horiguchi H, et al. Recombinant human soluble
thrombomodulin and mortality in severe pneumonia patients with
sepsis-associated disseminated intravascular coagulation: an observational nationwide study. J Thromb Haemost. 2015;13(1):31-40.
Umemura Y, Yamakawa K, Hayakawa M, et al. Concomitant
versus individual administration of antithrombin and thrombomodulin for sepsis-induced disseminated intravascular coagulation: a
nationwide Japanese registry study. Clin Appl Thromb Hemost.
2018;24(5):734-740.
Sawano H, Shigemitsu K, Yoshinaga Y, et al. Combination
therapy with antithrombin and recombinant human soluble thrombomodulin in patients with severe sepsis and disseminated intravascular coagulation. J Jpn Assoc Acute Med. 2013;24(3):119131. in Japanese].
Yasuda N, Goto K, Ohchi Y, et al. The efficacy and safety of antithrombin and recombinant human thrombomodulin combination
therapy in patients with severe sepsis and disseminated intravascular coagulation. J Crit Care. 2016;36:29-34.
Iba T, Hagiwara A, Saitoh D, et al. Effects of combination therapy
using antithrombin and thrombomodulin for sepsis-associated disseminated intravascular coagulation. Ann Intensive Care.
2017;7(1):110.
Levi M, van der Poll T. The role of natural anticoagulants in the
pathogenesis and management of systemic activation of coagulation and inflammation in critically ill patients. Semin Thromb
Hemost. 2008;34(5):459-468.
Ghimire S, Ravi S, Budhathoki R, et al. Current understanding and
future implications of sepsis-induced thrombocytopenia. Eur J
Haematol. 2021;106(3):301-305.
Hui P, Cook DJ, Lim W, et al. The frequency and clinical significance of thrombocytopenia complicating critical illness: a systematic review. Chest. 2011;139(2):271-278.
Fourrier F, Chopin C, Goudemand J, et al. Septic shock, multiple
organ failure, and disseminated intravascular coagulation.
Compared patterns of antithrombin III, protein C, and protein S
deficiencies. Chest. 1992;101(3):816-823.
Pettilä V, Pentti J, Pettilä M, et al. Predictive value of antithrombin III
and serum C-reactive protein concentration in critically ill patients
with suspected sepsis. Crit Care Med. 2002;30(2):271-275.
Matsubara T, Yamakawa K, Umemura Y, et al. Significance of
plasma fibrinogen level and antithrombin activity in sepsis: a multicenter cohort study using a cubic spline model. Thromb Res.
2019;181:17-23.
Claushuis TA, van Vught LA, Scicluna BP, et al.
Thrombocytopenia is associated with a dysregulated host response
in critically ill sepsis patients. Blood. 2016;127(24):3062-3072.
Thiery-Antier N, Binquet C, Vinault S, et al. Is thrombocytopenia
an early prognostic marker in septic shock? Crit Care Med.
2016;44(4):764-772.
Zhou H, Li Z, Liang H, et al. Thrombocytopenia and platelet
count recovery in patients with sepsis-3: a retrospective observational
study. Platelets. 2021:1-9. doi: 10.1080/09537104.2021.1970124
22. Zhou Z, Feng T, Xie Y, et al. Prognosis and rescue therapy for
sepsis-related severe thrombocytopenia in critically ill patients.
Cytokine. 2020;136:155227.
23. Mimuro J, Takahashi H, Kitajima I, et al. Impact of recombinant soluble thrombomodulin (thrombomodulin alfa) on disseminated intravascular coagulation. Thromb Res. 2013;131(5):
436-443.
24. Eguchi Y, Gando S, Ishikura H, et al. Post-marketing surveillance data
of thrombomodulin alfa: sub-analysis in patients with sepsis-induced
disseminated intravascular coagulation. J Intensive Care.
2014;2(1):30.
25. Arishima T, Ito T, Yasuda T, et al. Circulating activated
protein C levels are not increased in septic patients treated
with recombinant human soluble thrombomodulin. Thromb
J. 2018;16:24.
26. Iba T, Nakarai E, Takayama T, et al. Combination effect of antithrombin and recombinant human soluble thrombomodulin in a lipopolysaccharide induced rat sepsis model. Crit Care. 2009;13(6):
R203.
27. Asakura H, Ontachi Y, Mizutani T, et al. Decreased plasma activity of antithrombin or protein C is not due to consumption coagulopathy in septic patients with disseminated intravascular
coagulation. Eur J Haematol. 2001;67(3):170-175.
28. Ebina M, Fujino K, Inoue A, et al. Effects of serum albumin levels
on antithrombin supplementation outcomes among patients with
sepsis-associated coagulopathy: a retrospective study. Clin Med
Insights Blood Disord. 2019;12:1-6.
29. Tsirigotis P, Chondropoulos S, Frantzeskaki F, et al.
Thrombocytopenia in critically ill patients with severe sepsis/
septic shock: prognostic value and association with a distinct
serum cytokine profile. J Crit Care. 2016;32:9-15.
30. de Stoppelaar SF, van’t Veer C, Claushuis TA, et al.
Thrombocytopenia impairs host defense in gram-negative
pneumonia-derived sepsis in mice. Blood. 2014;124(25):37813790.
31. Chen Z, Zhang H, Qu M, et al. Review: the emerging role of neutrophil extracellular traps in sepsis and sepsis-associated thrombosis. Front Cell Infect Microbiol. 2021;11:653228.
32. Shimomura Y, Suga M, Kuriyama N, et al. Recombinant human
thrombomodulin inhibits neutrophil extracellular trap formation
in vitro. J Intensive Care. 2016;4:48.
33. Kato Y, Nishida O, Kuriyama N, et al. Effects of thrombomodulin in reducing lethality and suppressing neutrophil
extracellular trap formation in the lungs and liver in a
lipopolysaccharide-induced murine septic shock model. Int J
Mol Sci. 2021;22(9):4933.
34. Shrestha B, Ito T, Kakuuchi M, et al. Recombinant thrombomodulin suppresses histone-induced neutrophil extracellular trap formation. Front Immunol. 2019;10:2535.
35. Coppo P. Secondary thrombotic microangiopathies. Rev Med
Interne. 2017;38(11):731-736.
36. Guglielmetti G, Quaglia M, Sainaghi PP, et al. “War to the knife”
against thromboinflammation to protect endothelial function of
COVID-19 patients. Crit Care. 2020;24(1):365.
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