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〈原著〉脳由来神経栄養因子BDNFの心臓における発現と低酸素病態下での機能

森島 真幸 藤田 崇史 小野 克重 近畿大学

2020.03.31

概要

[Synopsis] Brain-derived neurotrophic factor (BDNF), conditionally secreted at active synapse through the stimulation of the tropomyosin-related kinase receptor B (TrkB) receptors, plays an important role in neuronal development, survival, and function. BDNF/TrkB signaling is reportedly essential for organ development or normal contractility in the mammalian heart. However, the expression patterns of BDNF/TrkB and their pathophysiologic roles are poorly understood in the heart. Here we report that BDNF/TrkB signaling is associated with cardiac automaticity in normal and hypoxic conditions. Expressions of BDNF and its receptor TrkB mRNAs in the atrium and the ventricle were abundant, which was approximately a half of those in brainstem or hippocampus, in an age-dependent manner. In hypoxic condition at 3 h (1%,O2), expression of BDNF mRNA was transiently activated in neonatal rat cardiomyocytes (126±7%), whereas this action was reduced (52±2%) at prolonged hypoxia (24 h). Reduction of the cellular automaticity, viability, and T-type Ca2+ channel expression by hypoxia were observed concomitantly with the inactivation of the BDNF/TrkB signal. Our data provide the first evidence that BDNF/TrkB signaling contributes to cardiac dysfunction under acute and prolonged hypoxia.

参考文献

derived neurotrophic factor protects against

1) Levy BI, Heusch G, Camici PG. (2019) The

cardiac

dysfunction

after

myocardial

many faces of myocardial ishaemia and

infraction via a central nervous system-

angina. Cardiovasc. Res., 115: 1460-1470.

mediated pathway. Arterioscler Thromb

2) Pries AR, Badimon L, Pries AR, Badimon L,

Vasc Biol., 32: 1902-1909.

Bugiardini R, Camici PG, Dorobantu M,

9) Lorgis L. Amoueux S, de Maistre E, Sicard

Duncker DJ, Escaned J, Koller A, Piek JJ,

P, Bejot Y, Zeller M, Vergely C, Sequeira-Le

de Wit C. (2015) Coronary vascular

Grand A, Lagrost AC, Berchoud J, Cottin Y,

regulation,

and

Rochette L. (2010) Serum brain-derived

collateralization: mechanisms and clinical

neurotrophic factor and platelet activation

implications on behalf of the working group

evaluated by soluble P-selectin and soluble

on

CD-40 ligand in patients with acute

coronary

remodelling,

pathophysiology

and

microcirculation. Eur. Heart. J., 36: 3134-

myocardial

3146.

Pharmacol., 24: 525-530.

infraction.

Fundam.

Clin.

3) Heusch G. (2016) The coronary circulation

10) Donovan MJ, Lin MI, Wiegen P, Ringstedt

as a target of cardioprotection. Circ. Res.,

T, Kraemer R, Hahn R, Wang S, Ibenez CF,

118: 1643-1658.

Rafii S, and Hempsteas BL. (2000) Brain

4) Groves JO. (2007) Is it time to reassess the

derived neurotrophic factor is an endothelial

BDNF hypothesis of depression? Mol.

cell

Psychiatry., 12 1079-1088.

intramyocardial

5) Lewin GR and Barde YA. (1996)

Physiology of the neurotrophins. Ann. Rev.

Neurosci., 19: 289-317.

6) Lu B, Nagappan G, Guan X, Nathan PJ,

survival

factor

vessel

required

for

stabilization.

Development, 127: 4531-4540.

11) Donovan MJ, Miranda R, Kraemer R,

McCaffrey T, Tessorollo L, Mahadeo D,

Kaplan DR, Tsoulfas P, Parada L, Toran-

Wren P. (2013) BDNF-based synaptic

Allerand C, Hajjar D, Hempstead BL.

repair as a disease-modifying strategy for

(1995) Neurotrophin and neurotrophin

neurodegenerative diseases. Nat. Rev.

receptors in vascular smooth muscle cells:

22

森島・藤田・小野

regulation of expression in response to

injury. Am. J. Pathol., 147: 309-324.

113: 1217-1224.

19) Karege F, Perret G, Bondolfi G, Schwald M,

12) Donovan MJ, Hahn R, Tessarollo L,

Bertschy G, Aubry JM. (2002) Decreased

Hempstead BL. (1996) Identification of an

serum brain-derived neurotrophic factor

essential

levels

nonneuronal

function

of

neurotrophin 3 in mammalian cardiac

development. Nat. Genet., 14: 210-213.

in

major

depressed

patients.

Psychiatry Res., 109: 143-148.

20) Ferris LT, Williams JS, Shen CL. (2007) The

13) Wang Y, Morishima M, Zheng M, Uchino T,

effect of acute exercise on serum brain-

Mannen K, Takahashi A, Nakaya Y,

derived neurotrophic factor levels and

Komuro I, Ono K. (2007) Transcription

congnitive function. Med. Sci. Sports Exerc.,

factors Csx/Nkx2.5 and GATA4 distinctly

39: 728-734.

regulate expression of Ca2+ channels in

21) Seifert T, Brassard P, Wissenberg M,

neonatal rat heart. J. Mol. Cell. Cardiol., 42:

Rasmussen P, Nordby P, Stanllknecht B,

1045-1053.

Adser H, Jakobsen AH, Pilegaard H,

14) Morishima M, Wang Y, Akiyoshi Y,

Nielsen HB, Secher NH. (2010) Endurance

Miyamoto S, Ono K. (2009) Telmisartan, an

training enhances BDNF release from the

angiotensin II type 1 receptor antagonist,

human brain. Am. J. Physiol. Regul. Integr.

attenuates T-type Ca2+ channel expression in

Comp. Physiol., 298: R372-377.

neonatal

rat

cardiomyocytes.

Eur.

J.

Pharmacol. ,609: 105-112.

22) Matthews VB, Astrom MB, Chan MH,

Bruce CR, Krabbe KS, Prelovsek O,

15) Del Toro R, Levitsky KL, Lopez-Bameo J,

Akerstrom T, Yfanti C, Broholm C,

Chiara MD. (2003) Induction of T-type

Mortensen OH, Penkowa M, Hojman P,

calcium channel gene expression by chronic

Zankari A, Watt MJ, Bruunsgaard H,

hypoxia. J. Biol. Chem., 278: 22316-22324.

Pedersen BK, Febbraio MA. (2009) Brain-

16) Cribbs LL. (2010) T-type calcium channel

derived neurotrophic factor is produced by

expression and function in the diseased

skeletal muscle cells in response to

heart. Channels., 4:447-452.

contraction and enhances fat oxidation via

17) Kaplan

DR,

Miller

FD.

(2000)

Neurotrophin signal transduction in the

nervous system. Curr. Opin. Neurobiol., 10:

381-391.

activation of AMP-activated protein kinase.

Diabetologia., 52: 1409-1418.

23) Fukushima A, Kinugawa S, Homma T,

Masaki Y, Furihata T, Yokota T, Matsushima

18) Laske C, Stransky E, Leyhe T, Eschweiler

S, Takada S, Kadoguchi T, Oba K, Okita K,

GW, Wittorf A, Richartz E, Bartels M,

Tsutsui H. (2015) Serum brain-derived

Buchkremer G, Schott K. (2006) Stage-

neurotrophic factor level predicts adverse

dependent BDNF serum concentration in

clinical outcomes in patients with heart

Alzheimer’s disease. J. Neural. Transm.,

failure. J. Card. Fail., 21: 300-306.

脳由来神経栄養因子 BDNF の心臓における発現と低酸素病態下での機能

23

24) Helan M, Aravamudan B, Hartman WR,

29) Gao Y, Jing M, Ge R, Lang L. (2016)

Thompson MA, Johnson BD, Pabelick CM,

Induction of hypoxia-inducible factor-1 by

Prakash YS. (2014) BDNF secretion by

BDNF protects retinoblastoma cells against

human pulmonary artery endothelial cells in

chemotherapy-induced apoptosis. Mol. Cell.

response to hypoxia. J. Mol. Cell. Cardiol.,

Biochem., 414: 77-84.

68: 89-97.

30) Suzuki T, Kojima N, Osuka Y, Tokui Y,

25) Takebayashi S, Li Y, Kaku T, Inagaki S,

Takasugi S, Kawashima A, Yamaji T, Hosoi

Hashimoto Y, Kimura K, Miyamoto S,

E, Won CW, Kim H. (2019) The Effects of

Hadama T, Ono K. (2006) Remodeling

Mold-Fermented Cheese on Brain-Derived

excitation-contraction

of

Neurotrophic

is

Dwelling Older Japanese Women With Mild

dependent on T-type calcium channels

Cognitive Impairment: A Randomized,

expression.

Controlled, Crossover Trial. JAMDA., 20:

hypertrophied

coupling

ventricular

Biochem.

myocytes

Biophys.

Res.

Commun., 345: 766-773.

Factor

in

Community-

1509-1514.

26) Wan J, Yamamura A, Zimnicka AM, Voiriot

31) Huang Z, Zhong XM, Li ZY, Feng CR, Pan

G, Smith KA, Tang H, Ayon RJ, Choudhury

AJ, Mao QQ. (2011) Curcumin reverses

MSR, Ko EA, Wang J, Wang C, Makino A,

corticosterone-induced

Yuan

hypoxia

behavior and decrease in brain BDNF levels

selectively enhances L- and T-type voltage-

in rats. Neuroscience Letters., 493: 145–148.

JXJ.

(2013)

Ca2+

Chronic

in

32) Ali SH, Madhana RM, Athira K.V., Kasala

pulmonary artery by upregulating Cav1.2

ER, Bodduluru LN, Pitta S, Mahareddy JR,

and Cav3.2. Am. J. Physiol. Lung. Cell. Mol.

Lahkar M. (2015) Resveratrol ameliorates

Physiol., 305: L154-L164.

depressive-like

dependent

channel

activity

depressive-like

27) Chevalier M, Gilbert G, Roux E, LoryP,

Marthan R, Savineau JP, Quignard JF.

(2014)

involved

T-type

in

calcium

hypoxic

channels

are

pulmonary

hypertension. Cardiovasc. Res., 103: 597606.

28) Feng N, Huke S, Zhu G, Tocchetti CG, Shi

S, Aiba T, Kaludercic N, Hoover DB, Beck

SE, Mankowski JL, Tomaselli GF, Bers DM,

Kass DA. (2015) Constitutive BDNF/TrkB

signaling is required for normal cardiac

contraction and relaxation. Proc. Natl. Acad.

Sci. USA., 112: 1880-1885.

behavior

in

repeated

corticosterone-induced depression in mice.

Steroids., 101: 37-42.

...

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