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Comparison of neurological manifestation in children with and without coronavirus 2019 experiencing seizures with fever

Hongo, Hiroto Nishiyama, Masahiro Ueda, Takuya Ishida, Yusuke Kasai, Masashi Tanaka, Ryojiro Nagase, Hiroaki Maruyama, Azusa 神戸大学

2023

概要

Whether neurologic symptoms due to SARS-CoV-2 differ from those of non-SARS-CoV-2 viral infection is unclear. We aimed to describe these neurological manifestations and compare the clinical characteristics and treatments in children with seizures and fever with or without COVID-19. We retrospectively analyzed data from 105 hospitalized children (<18 years) with clinical seizures and fever between September 2021 and August 2022. We compared the clinical characteristics and treatments between the COVID-19 (n = 20) and non-COVID-19 (n = 85) groups. Patients with COVID-19 were older than those without (32.5 [20–86] months vs. 20 [16–32] months, p = 0.029). Seizure type and duration and impaired consciousness duration did not differ between groups. Six and 32 patients experienced status epilepticus lasting 30 min in the COVID-19 and non-COVID-19 groups, respectively. Most treatments did not differ between groups; however, electroencephalography was used less frequently for COVID-19. Neurological sequelae occurred in one and four patients in the COVID-19 and non-COVID-19 groups, respectively. In conclusion, seizures with fever due to SARS-CoV-2 were more common in older children. Seizure characteristics and neurologic sequelae did not differ in children with and those without COVID-19. In general, electroencephalography was used less during COVID-19 for infection control measures.

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参考文献

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5. Conclusions

Seizures with fever due to SARS-CoV-2 were more common in older

children compared with seizures due to other viruses. Seizure charac­

teristics and neurologic sequelae do not differ in children with and those

without COVID-19. In general, EEG monitoring was used less during

COVID-19 for infection control measures. The neurological manifesta­

tions of COVID-19 in this study will contribute to the appropriate

treatment and management of COVID-19 in the future.

Declaration of Competing Interest

The authors declare that they have no known competing financial

interests or personal relationships that could have appeared to influence

the work reported in this paper.

Acknowledgments

The authors would like to thank all the staff who treated and cared

for the patients. We especially thank the staff in the Department of

Emergency and General Pediatrics and Department of Pediatric Critical

Care Medicine of Hyogo Prefectural Kobe Children’s Hospital. In addi­

tion, we would like to thank Editage (www.editage.com) for English

language editing.

Financial support

This work was partly supported by JSPS KAKENHI [grant number

JP22K09119] and a Grant-in-Aid [grant number 2020C02] from the

Japan Intractable Diseases (Nanbyo) Research Foundation to MN, and a

Grant-in-Aid for Research on Measures for Intractable Diseases [grant

number 21FC1005] from the Ministry of Health, Labour, and Welfare to

HN.

Data statement

Data not available/The data that has been used is confidential.

H. Hongo et al.

Epilepsy & Behavior Reports 24 (2023) 100625

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