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Neutrophil S100A9 supports M2 macrophage niche formation in granulomas

Mizutani, Tatsuaki Ano, Toshiaki Yoshioka, Yuya Mizuta, Satoshi Takemoto, Keiko Ouchi, Yuki Morita, Daisuke Kitano, Satsuki Miyachi, Hitoshi Tsuruyama, Tatsuaki Fujiwara, Nagatoshi Sugita, Masahiko 京都大学 DOI:10.1016/j.isci.2023.106081

2023.03.17

概要

Mycobacterium infection gives rise to granulomas predominantly composed of inflammatory M1-like macrophages, with bacteria-permissive M2 macrophages also detected in deep granulomas. Our histological analysis of Mycobacterium bovis bacillus Calmette-Guerin-elicited granulomas in guinea pigs revealed that S100A9-expressing neutrophils bordered a unique M2 niche within the inner circle of concentrically multilayered granulomas. We evaluated the effect of S100A9 on macrophage M2 polarization based on guinea pig studies. S100A9-deficient mouse neutrophils abrogated M2 polarization, which was critically dependent on COX-2 signaling in neutrophils. Mechanistic evidence suggested that nuclear S100A9 interacts with C/EBPβ, which cooperatively activates the Cox-2 promoter and amplifies prostaglandin E2 production, followed by M2 polarization in proximal macrophages. Because the M2 populations in guinea pig granulomas were abolished via treatment with celecoxib, a selective COX-2 inhibitor, we propose the S100A9/Cox-2 axis as a major pathway driving M2 niche formation in granulomas.

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