Adachi, A., Ono, N., Sakai, H., Ogawa, K., Shibata, R., Kiyomasu, T., Masuike, H., and Ueda, S. (1991). Generation and characterization of the human immunodeficiency virus type 1 mutants. Arch Virol 117, 45-58.
Alvarez-Fernandez, C., Crespo Guardo, A., Garcia-Perez, J., Garcia, F., Blanco, J., Escriba- Garcia, L., Gatell, J.M., Alcami, J., Plana, M., and Sanchez-Palomino, S. (2012). Generation and characterization of a defective HIV-1 Virus as an immunogen for a therapeutic vaccine. PLoS One 7, e48848.
Bajar, B.T., Wang, E.S., Zhang, S., Lin, M.Z., and Chu, J. (2016). A Guide to Fluorescent Protein FRET Pairs. Sensors (Basel) 16.
Bruner, K.M., Murray, A.J., Pollack, R.A., Soliman, M.G., Laskey, S.B., Capoferri, A.A., Lai, J., Strain, M.C., Lada, S.M., Hoh, R., Ho, Y.C., Richman, D.D., Deeks, S.G., Siliciano, J.D., and Siliciano, R.F. (2016). Defective proviruses rapidly accumulate during acute HIV-1 infection. Nat Med 22, 1043-1049.
Burdick, R.C., Li, C., Munshi, M., Rawson, J.M.O., Nagashima, K., Hu, W.S., and Pathak, V.K. (2020). HIV-1 uncoats in the nucleus near sites of integration. Proc Natl Acad Sci U S A 117, 5486-5493.
Campbell, E.M., and Hope, T.J. (2008). Live cell imaging of the HIV-1 life cycle. Trends Microbiol 16, 580-587.
Castilla, J., Del Romero, J., Hernando, V., Marincovich, B., Garcia, S., and Rodriguez, C. (2005). Effectiveness of highly active antiretroviral therapy in reducing heterosexual transmission of HIV. J Acquir Immune Defic Syndr 40, 96-101.
Chen, J., Nikolaitchik, O., Singh, J., Wright, A., Bencsics, C.E., Coffin, J.M., Ni, N., Lockett, S., Pathak, V.K., and Hu, W.S. (2009). High efficiency of HIV-1 genomic RNA packaging and heterozygote formation revealed by single virion analysis. Proc Natl Acad Sci U S A 106, 13535-13540.
Chiu, T.Y., and Yang, D.M. (2012). Intracellular Pb2+ content monitoring using a protein- based Pb2+ indicator. Toxicol Sci 126, 436-445.
Chu, H., Wang, J.J., Qi, M., Yoon, J.J., Wen, X., Chen, X., Ding, L., and Spearman, P. (2012). The intracellular virus-containing compartments in primary human macrophages are largely inaccessible to antibodies and small molecules. PLoS One 7, e35297.
Chun, T.W., Stuyver, L., Mizell, S.B., Ehler, L.A., Mican, J.A., Baseler, M., Lloyd, A.L., Nowak, M.A., and Fauci, A.S. (1997). Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy. Proc Natl Acad Sci U S A 94, 13193- 13197.
Colby, D.J., Trautmann, L., Pinyakorn, S., Leyre, L., Pagliuzza, A., Kroon, E., Rolland, M., Takata, H., Buranapraditkun, S., Intasan, J., Chomchey, N., Muir, R., Haddad, E.K., Tovanabutra, S., Ubolyam, S., Bolton, D.L., Fullmer, B.A., Gorelick, R.J., Fox, L., Crowell, T.A., Trichavaroj, R., O'connell, R., Chomont, N., Kim, J.H., Michael, N.L., Robb, M.L., Phanuphak, N., Ananworanich, J., and Group, R.V.S. (2018). Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection. Nat Med 24, 923-926.
Daar, E.S., Bai, J., Hausner, M.A., Majchrowicz, M., Tamaddon, M., and Giorgi, J.V. (1998). Acute HIV syndrome after discontinuation of antiretroviral therapy in a patient treated before seroconversion. Ann Intern Med 128, 827-829.
Davidoff, C., Payne, R.J., Willis, S.H., Doranz, B.J., and Rucker, J.B. (2012). Maturation of the Gag core decreases the stability of retroviral lipid membranes. Virology 433, 401- 409.
De Marco, A., Heuser, A.M., Glass, B., Krausslich, H.G., Muller, B., and Briggs, J.A. (2012). Role of the SP2 domain and its proteolytic cleavage in HIV-1 structural maturation and infectivity. J Virol 86, 13708-13716.
De Meyer, S., Azijn, H., Surleraux, D., Jochmans, D., Tahri, A., Pauwels, R., Wigerinck, P., and De Bethune, M.P. (2005). TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates. Antimicrob Agents Chemother 49, 2314-2321.
De Rocquigny, H., El Meshri, S.E., Richert, L., Didier, P., Darlix, J.L., and Mely, Y. (2014). Role of the nucleocapsid region in HIV-1 Gag assembly as investigated by quantitative fluorescence-based microscopy. Virus Res 193, 78-88.
Elliott, J.L., and Kutluay, S.B. (2020). Going beyond Integration: The Emerging Role of HIV-1 Integrase in Virion Morphogenesis. Viruses 12.
Finzi, D., Blankson, J., Siliciano, J.D., Margolick, J.B., Chadwick, K., Pierson, T., Smith, K., Lisziewicz, J., Lori, F., Flexner, C., Quinn, T.C., Chaisson, R.E., Rosenberg, E., Walker, B., Gange, S., Gallant, J., and Siliciano, R.F. (1999). Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nat Med 5, 512-517.
Finzi, D., Hermankova, M., Pierson, T., Carruth, L.M., Buck, C., Chaisson, R.E., Quinn, T.C., Chadwick, K., Margolick, J., Brookmeyer, R., Gallant, J., Markowitz, M., Ho, D.D., Richman, D.D., and Siliciano, R.F. (1997). Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science 278, 1295-1300.
Finzi, D., Plaeger, S.F., and Dieffenbach, C.W. (2006). Defective virus drives human immunodeficiency virus infection, persistence, and pathogenesis. Clin Vaccine Immunol 13, 715-721.
Fontana, J., Jurado, K.A., Cheng, N., Ly, N.L., Fuchs, J.R., Gorelick, R.J., Engelman, A.N., and Steven, A.C. (2015). Distribution and Redistribution of HIV-1 Nucleocapsid Protein in Immature, Mature, and Integrase-Inhibited Virions: a Role for Integrase in Maturation. J Virol 89, 9765-9780.
Forshey, B.M., Von Schwedler, U., Sundquist, W.I., and Aiken, C. (2002). Formation of a human immunodeficiency virus type 1 core of optimal stability is crucial for viral replication. J Virol 76, 5667-5677.
Francis, A.C., and Melikyan, G.B. (2018). Live-Cell Imaging of Early Steps of Single HIV-1 Infection. Viruses 10.
Freed, E.O. (2015). HIV-1 assembly, release and maturation. Nat Rev Microbiol 13, 484-496. Fukuda, H., Li, S., Sardo, L., Smith, J.L., Yamashita, K., Sarca, A.D., Shirakawa, K., Standley, D.M., Takaori-Kondo, A., and Izumi, T. (2019). Structural Determinants of the APOBEC3G N-Terminal Domain for HIV-1 RNA Association. Front Cell Infect Microbiol 9, 129.
Gao, D., Wu, J., Wu, Y.T., Du, F., Aroh, C., Yan, N., Sun, L., and Chen, Z.J. (2013). Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses. Science 341, 903-906.
Gao, F., Morrison, S.G., Robertson, D.L., Thornton, C.L., Craig, S., Karlsson, G., Sodroski, J., Morgado, M., Galvao-Castro, B., Von Briesen, H., Beddows, S., Weber, J., Sharp, P.M., Shaw, G.M., and Hahn, B.H. (1996). Molecular cloning and analysis of functional envelope genes from human immunodeficiency virus type 1 sequence subtypes A through G. The WHO and NIAID Networks for HIV Isolation and Characterization. J Virol 70, 1651-1667.
Gonelli, C.A., Khoury, G., Center, R.J., and Purcell, D.F.J. (2019). HIV-1-based Virus-like Particles that Morphologically Resemble Mature, Infectious HIV-1 Virions. Viruses 11.
Gousset, K., Ablan, S.D., Coren, L.V., Ono, A., Soheilian, F., Nagashima, K., Ott, D.E., and Freed, E.O. (2008). Real-time visualization of HIV-1 GAG trafficking in infected macrophages. PLoS Pathog 4, e1000015.
Groot, F., Welsch, S., and Sattentau, Q.J. (2008). Efficient HIV-1 transmission from macrophages to T cells across transient virological synapses. Blood 111, 4660-4663.
Hassan, J., Browne, K., and De Gascun, C. (2016). HIV-1 in Monocytes and Macrophages: An Overlooked Reservoir? Viral Immunol 29, 532-533.
Heim, R., and Tsien, R.Y. (1996). Engineering green fluorescent protein for improved brightness, longer wavelengths and fluorescence resonance energy transfer. Curr Biol 6, 178-182.
Henrich, T.J., Hatano, H., Bacon, O., Hogan, L.E., Rutishauser, R., Hill, A., Kearney, M.F., Anderson, E.M., Buchbinder, S.P., Cohen, S.E., Abdel-Mohsen, M., Pohlmeyer, C.W., Fromentin, R., Hoh, R., Liu, A.Y., Mccune, J.M., Spindler, J., Metcalf-Pate, K., Hobbs, K.S., Thanh, C., Gibson, E.A., Kuritzkes, D.R., Siliciano, R.F., Price, R.W., Richman, D.D., Chomont, N., Siliciano, J.D., Mellors, J.W., Yukl, S.A., Blankson, J.N., Liegler, T., and Deeks, S.G. (2017). HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study. PLoS Med 14, e1002417.
Hiener, B., Horsburgh, B.A., Eden, J.S., Barton, K., Schlub, T.E., Lee, E., Von Stockenstrom, S., Odevall, L., Milush, J.M., Liegler, T., Sinclair, E., Hoh, R., Boritz, E.A., Douek, D., Fromentin, R., Chomont, N., Deeks, S.G., Hecht, F.M., and Palmer, S. (2017). Identification of Genetically Intact HIV-1 Proviruses in Specific CD4(+) T Cells from Effectively Treated Participants. Cell Rep 21, 813-822.
Ho, Y.C., Shan, L., Hosmane, N.N., Wang, J., Laskey, S.B., Rosenbloom, D.I., Lai, J., Blankson, J.N., Siliciano, J.D., and Siliciano, R.F. (2013). Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure. Cell 155, 540-551.
Holkmann Olsen, C., Mocroft, A., Kirk, O., Vella, S., Blaxhult, A., Clumeck, N., Fisher, M., Katlama, C., Phillips, A.N., Lundgren, J.D., and Euro, S.S.G. (2007). Interruption of combination antiretroviral therapy and risk of clinical disease progression to AIDS or death. HIV Med 8, 96-104.
Hubner, W., and Chen, B.K. (2006). Inhibition of viral assembly in murine cells by HIV-1 matrix. Virology 352, 27-38.
Hubner, W., Chen, P., Del Portillo, A., Liu, Y., Gordon, R.E., and Chen, B.K. (2007). Sequence of human immunodeficiency virus type 1 (HIV-1) Gag localization and oligomerization monitored with live confocal imaging of a replication-competent, fluorescently tagged HIV-1. J Virol 81, 12596-12607.
Hubner, W., Mcnerney, G.P., Chen, P., Dale, B.M., Gordon, R.E., Chuang, F.Y., Li, X.D., Asmuth, D.M., Huser, T., and Chen, B.K. (2009). Quantitative 3D video microscopy of HIV transfer across T cell virological synapses. Science 323, 1743-1747.
Imamichi, H., Dewar, R.L., Adelsberger, J.W., Rehm, C.A., O'doherty, U., Paxinos, E.E., Fauci, A.S., and Lane, H.C. (2016). Defective HIV-1 proviruses produce novel protein-coding RNA species in HIV-infected patients on combination antiretroviral therapy. Proc Natl Acad Sci U S A 113, 8783-8788.
Imamichi, H., Smith, M., Adelsberger, J.W., Izumi, T., Scrimieri, F., Sherman, B.T., Rehm, C.A., Imamichi, T., Pau, A., Catalfamo, M., Fauci, A.S., and Lane, H.C. (2020). Defective HIV-1 proviruses produce viral proteins. Proc Natl Acad Sci U S A 117, 3704-3710.
Inlora, J., Chukkapalli, V., Bedi, S., and Ono, A. (2016). Molecular Determinants Directing HIV-1 Gag Assembly to Virus-Containing Compartments in Primary Macrophages. J Virol 90, 8509-8519.
Jouvenet, N., Bieniasz, P.D., and Simon, S.M. (2008). Imaging the biogenesis of individual HIV-1 virions in live cells. Nature 454, 236-240.
Jouvenet, N., Neil, S.J., Bess, C., Johnson, M.C., Virgen, C.A., Simon, S.M., and Bieniasz, P.D. (2006). Plasma membrane is the site of productive HIV-1 particle assembly. PLoS Biol 4, e435.
Keller, P.W., Huang, R.K., England, M.R., Waki, K., Cheng, N., Heymann, J.B., Craven, R.C., Freed, E.O., and Steven, A.C. (2013). A two-pronged structural analysis of retroviral maturation indicates that core formation proceeds by a disassembly- reassembly pathway rather than a displacive transition. J Virol 87, 13655-13664.
Kessl, J.J., Kutluay, S.B., Townsend, D., Rebensburg, S., Slaughter, A., Larue, R.C., Shkriabai, N., Bakouche, N., Fuchs, J.R., Bieniasz, P.D., and Kvaratskhelia, M. (2016). HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis. Cell 166, 1257-1268 e1212.
Kitahata, M.M., Gange, S.J., Abraham, A.G., Merriman, B., Saag, M.S., Justice, A.C., Hogg, R.S., Deeks, S.G., Eron, J.J., Brooks, J.T., Rourke, S.B., Gill, M.J., Bosch, R.J., Martin, J.N., Klein, M.B., Jacobson, L.P., Rodriguez, B., Sterling, T.R., Kirk, G.D., Napravnik, S., Rachlis, A.R., Calzavara, L.M., Horberg, M.A., Silverberg, M.J., Gebo, K.A., Goedert, J.J., Benson, C.A., Collier, A.C., Van Rompaey, S.E., Crane, H.M., Mckaig, R.G., Lau, B., Freeman, A.M., Moore, R.D., and Investigators, N.-A. (2009). Effect of early versus deferred antiretroviral therapy for HIV on survival. N Engl J Med 360, 1815-1826.
Kousignian, I., Abgrall, S., Grabar, S., Mahamat, A., Teicher, E., Rouveix, E., Costagliola, D., and Clinical Epidemiology Group of the French Hospital Database On, H.I.V. (2008). Maintaining antiretroviral therapy reduces the risk of AIDS-defining events in patients with uncontrolled viral replication and profound immunodeficiency. Clin Infect Dis 46, 296-304.
Kremers, G.J., Goedhart, J., Van Munster, E.B., and Gadella, T.W., Jr. (2006). Cyan and yellow super fluorescent proteins with improved brightness, protein folding, and FRET Forster radius. Biochemistry 45, 6570-6580.
Lee, K.K., and Gui, L. (2016). Dissecting Virus Infectious Cycles by Cryo-Electron Microscopy. PLoS Pathog 12, e1005625.
Link, J.O., Rhee, M.S., Tse, W.C., Zheng, J., Somoza, J.R., Rowe, W., Begley, R., Chiu, A., Mulato, A., Hansen, D., Singer, E., Tsai, L.K., Bam, R.A., Chou, C.H., Canales, E., Brizgys, G., Zhang, J.R., Li, J., Graupe, M., Morganelli, P., Liu, Q., Wu, Q., Halcomb, R.L., Saito, R.D., Schroeder, S.D., Lazerwith, S.E., Bondy, S., Jin, D., Hung, M., Novikov, N., Liu, X., Villasenor, A.G., Cannizzaro, C.E., Hu, E.Y., Anderson, R.L., Appleby, T.C., Lu, B., Mwangi, J., Liclican, A., Niedziela-Majka, A., Papalia, G.A., Wong, M.H., Leavitt, S.A., Xu, Y., Koditek, D., Stepan, G.J., Yu, H., Pagratis, N., Clancy, S., Ahmadyar, S., Cai, T.Z., Sellers, S., Wolckenhauer, S.A., Ling, J., Callebaut, C., Margot, N., Ram, R.R., Liu, Y.P., Hyland, R., Sinclair, G.I., Ruane, P.J., Crofoot, G.E., Mcdonald, C.K., Brainard, D.M., Lad, L., Swaminathan, S., Sundquist, W.I., Sakowicz, R., Chester, A.E., Lee, W.E., Daar, E.S., Yant, S.R., and Cihlar, T. (2020). Clinical targeting of HIV capsid protein with a long-acting small molecule. Nature 584, 614-618.
Mattei, S., Flemming, A., Anders-Osswein, M., Krausslich, H.G., Briggs, J.A., and Muller, B. (2015). RNA and Nucleocapsid Are Dispensable for Mature HIV-1 Capsid Assembly. J Virol 89, 9739-9747.
Mattei, S., Tan, A., Glass, B., Muller, B., Krausslich, H.G., and Briggs, J.a.G. (2018). High- resolution structures of HIV-1 Gag cleavage mutants determine structural switch for virus maturation. Proc Natl Acad Sci U S A 115, E9401-E9410.
Muller, B., Anders, M., and Reinstein, J. (2014). In vitro analysis of human immunodeficiency virus particle dissociation: gag proteolytic processing influences dissociation kinetics. PLoS One 9, e99504.
Nagai, T., Yamada, S., Tominaga, T., Ichikawa, M., and Miyawaki, A. (2004). Expanded dynamic range of fluorescent indicators for Ca(2+) by circularly permuted yellow fluorescent proteins. Proc Natl Acad Sci U S A 101, 10554-10559.
Novikova, M., Zhang, Y., Freed, E.O., and Peng, K. (2019). Multiple Roles of HIV-1 Capsid during the Virus Replication Cycle. Virol Sin 34, 119-134.
Ono, A., and Freed, E.O. (2004). Cell-type-dependent targeting of human immunodeficiency virus type 1 assembly to the plasma membrane and the multivesicular body. J Virol 78, 1552-1563.
Pelchen-Matthews, A., Kramer, B., and Marsh, M. (2003). Infectious HIV-1 assembles in late endosomes in primary macrophages. J Cell Biol 162, 443-455.
Pornillos, O., and Ganser-Pornillos, B.K. (2019). Maturation of retroviruses. Curr Opin Virol 36, 47-55.
Preus, S., and Wilhelmsson, L.M. (2012). Advances in quantitative FRET-based methods for studying nucleic acids. Chembiochem 13, 1990-2001.
Rabi, S.A., Laird, G.M., Durand, C.M., Laskey, S., Shan, L., Bailey, J.R., Chioma, S., Moore, R.D., and Siliciano, R.F. (2013). Multi-step inhibition explains HIV-1 protease inhibitor pharmacodynamics and resistance. J Clin Invest 123, 3848-3860.
Rankovic, S., Varadarajan, J., Ramalho, R., Aiken, C., and Rousso, I. (2017). Reverse Transcription Mechanically Initiates HIV-1 Capsid Disassembly. J Virol 91.
Sardo, L., Hatch, S.C., Chen, J., Nikolaitchik, O., Burdick, R.C., Chen, D., Westlake, C.J., Lockett, S., Pathak, V.K., and Hu, W.S.(2015). Dynamics of HIV-1 RNA Near the Plasma Membrane during Virus Assembly. J Virol 89, 10832-10840.
Sekar, R.B., and Periasamy, A. (2003). Fluorescence resonance energy transfer (FRET) microscopy imaging of live cell protein localizations. J Cell Biol 160, 629-633.
Sharova, N., Swingler, C., Sharkey, M., and Stevenson, M. (2005). Macrophages archive HIV-1 virions for dissemination in trans. EMBO J 24, 2481-2489.
Siddiqui, M.A., Saito, A., Halambage, U.D., Ferhadian, D., Fischer, D.K., Francis, A.C., Melikyan, G.B., Ambrose, Z., Aiken, C., and Yamashita, M. (2019). A Novel Phenotype Links HIV-1 Capsid Stability to cGAS-Mediated DNA Sensing. J Virol 93.
Siliciano, J.D., Kajdas, J., Finzi, D., Quinn, T.C., Chadwick, K., Margolick, J.B., Kovacs, C., Gange, S.J., and Siliciano, R.F. (2003). Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells. Nat Med 9, 727- 728.
Sood, C., Francis, A.C., Desai, T.M., and Melikyan, G.B. (2017). An improved labeling strategy enables automated detection of single-virus fusion and assessment of HIV-1 protease activity in single virions. J Biol Chem 292, 20196-20207.
Spagnuolo, V., Castagna, A., and Lazzarin, A. (2018). Darunavir for the treatment of HIV infection. Expert Opin Pharmacother 19, 1149-1163.
Wang, L., Izadmehr, S., Kamau, E., Kong, X.P., and Chen, B.K. (2019). Sequential trafficking of Env and Gag to HIV-1 T cell virological synapses revealed by live imaging. Retrovirology 16, 2.
Whitney, J.B., Hill, A.L., Sanisetty, S., Penaloza-Macmaster, P., Liu, J., Shetty, M., Parenteau, L., Cabral, C., Shields, J., Blackmore, S., Smith, J.Y., Brinkman, A.L., Peter, L.E., Mathew, S.I., Smith, K.M., Borducchi, E.N., Rosenbloom, D.I., Lewis, M.G., Hattersley, J., Li, B., Hesselgesser, J., Geleziunas, R., Robb, M.L., Kim, J.H., Michael, N.L., and Barouch, D.H. (2014). Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys. Nature 512, 74-77.
Wong, M.E., Jaworowski, A., and Hearps, A.C. (2019). The HIV Reservoir in Monocytes and Macrophages. Front Immunol 10, 1435.
Zhang, L., Chung, C., Hu, B.S., He, T., Guo, Y., Kim, A.J., Skulsky, E., Jin, X., Hurley, A., Ramratnam, B., Markowitz, M., and Ho, D.D. (2000). Genetic characterization of rebounding HIV-1 after cessation of highly active antiretroviral therapy. J Clin Invest 106, 839-845.
Zurnic Bonisch, I., Dirix, L., Lemmens, V., Borrenberghs, D., De Wit, F., Vernaillen, F., Rocha, S., Christ, F., Hendrix, J., Hofkens, J., and Debyser, Z. (2020). Capsid-Labelled HIV To Investigate the Role of Capsid during Nuclear Import and Integration. J Virol 94.
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