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Optical Detection of Macular Pigment Formation in Premature Infants

笹野, 紘之 東京慈恵会医科大学 DOI:info:doi/10.1167/tvst.7.4.3

2020.10.21

概要

Purpose:
To demonstrate the presence of macular pigment in the retina of premature infants, and to examine its changes with age.

Methods:
The participants included 40 premature infants. Infants who had received laser photocoagulation for retinopathy of prematurity were excluded. Macular pigment optical density (MPOD) was measured by fundus reflectometry using RetCam3, a digital fundus camera. The reflection imaging was performed for ROP screening. The imaging time points were from a post menstrual age (PMA) of 29 weeks 0 days to 46 weeks 5 days.

Results:
The MPOD levels could be obtained from 39 premature infants. The levels at the first measurement ranged from 0 to 0.18 (mean 0.076, SD 0.044). The earliest time, when a nonvanishing MPOD level was obtained, was at a PMA of 33 weeks and 2 days, and that level was 0.05. The initial examination MPOD levels showed a moderate correlation with age (R2 = 0.32, P < 0.00017). The mean MPOD levels measured each week during the follow-up period showed a very strong correlation with age (R2 = 0.91, P < 0.0001). A regression line of MPOD = 0.0069 × age — 0.1783 was derived, where age is counted in PMA days.

Conclusions:
The MPOD levels of premature infants were for the first time measured in living eyes. Macular pigment increased linearly with age.

Translational Relevance:
Macular pigment increased with the development of macular morphology. This result suggested the importance of nutritional manage- ment of infants and mothers during perinatal period.

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参考文献

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