1. Kang, I). H. et al. A role for uric acid in the progression of renal disease. J. Am. Soc. Nephrol.13, 2888-2897, https://doi. org/10.1097/01.ASN.0000034910.58454.FD (2002).
2. Uchida, S. et al. Targeling Uric Acid and the Inhibition of Progression to End-Stage Renal Disease-Λ Propensity Score Analysis. PLoS One 10, eO 145506, https://doi.org/10.1371/journal.pone.0145506 (2015).
3. Feig D. 1., Kang D. H., Johnson R. J. Uric acid and cardiovascular risk. N. Engl. J. Med. 359, 1811-1821, https://doi.org/10.1056/NI-JMraO800885 (2008), Erratum in: N. Engl. J. Med. 362,2235, https://doi.org/10.1056/NEJMx 100028 (2010).
4. Kuriyama, S. ct al. Serum uric acid and the incidence of CKD and hypertension. Clin. Exp. Nephrol.19,1127-1134, https://doi. org/10.1007/sl0157-015-U20-4(2015).
5. Forman, J. R et al. Association between sodium intake and change in uric acid, urine albumin excretion, and the risk of developing hypertension. Circulation 125,3108-3116, https://doi.Org/10.l161/CIRCULATIONAHA.l 12.096115 (2012).
6. Cicero, A. E et al. Brisighelia Heart Study Group. High serum uric acid is associated to poorly controlled blood pressure and higher arterial stiffness in hypertensive subjects. Eur J Intern Med. 37,38-42, https://doi.org/10.1016/j.ejim.2016.07.026. (2017). Epub20I6 Aug 3.
7. Kodama, S. et al. Association between serum uric acid and development of type 2 diabetes. Diabetes Care. 32,1737-1742, https:// doi.org/10.2337/dc09 0288 (2009).
8. Cicero AFG et al. Brisighelia Heart Study Group. LDL-oxidation, serum uric acid, kidney function and pulse-wave velocity: Data from the Brisighelia Heart Study cohort. Int J Cardiol. 261,204-208, https://doi.org/10.1016/j.ijcard.2018.03.077. Epub 2018 Marl7 (2018).
9. Hare J. M., Johnson R. J. Uric acid predicts clinical outcomes in heart failure: insights regarding the role of xanthine oxidase and uric acid in disease pathophysiology. Circulation 2003 107,1951-1953, https://doi.org/10.1161 /01.CIR.0000066420.36123.35 (2003).
10. Sakai, H. et al. Serum level of uric acid, partly secreted from the failing heart, is a prognostic marker in patients with congestive heart failure. Circ. J. 70, 1006-1011,https://doi.org/10. 1253/circj.70.1006 (2006).
11. Volterrani, M., lellamo, E, Sposato, B. & Romeo, E Uric acid lowering therapy in cardiovascular diseases. Int. J. Cardiol. 213,20-22, https://doi.org/10.1 016/j.ijcard.2015.08.088 (2016).
12. Dochner, W. et al. Uric acid and xanthine oxidase in heart failure - Emerging data and therapeutic implications. Int. J. Cardiol. 213, 15-19, https://doi.org/10.1016/j.ijcard.2015.08.089 (2016).
13. Okazaki, I I. et al. Ihe prognostic impact of uric acid in patients with severely decompensated acute heart failure. J. Cardiol. 68, 384-391,https://doi.org/10.1016/j.jjcc.2016.04.013 (2016).
14. Tanaka, Y. et al. Close linkage between scrum uric acid and cardiac dysfunction in patients with ischemic heart disease according to covariance structure analysis. Sei. Rep. 7,2519, https://doi.org/1 0.1038/s41598-017-02707-y (2017).
15. Sudoh, T., Kangawa, K., Minamino. N. & Matsuo, Η. Λ new natriuretic peptide in porcine brain. Nature 332, 78-81, https://doi. org/10.1038/332078a0 (1988).
16. Mukoyama, M. et al. Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide. J. Clin. Invest. 87,1402-1412, https://doi.org/10.1172/ JCI115146 (1991).
17. Yasue, H. et al. Localization and mechanism of secretion ofB-type natriuretic peptide in comparison with those of A-type natriuretic peptide in normal subjects and patients with heart failure. Circulation 90,195-203, https://doi.0rg/101.1161 /circ.90.1.8025996 (1994).