Pre-treatment hematuria and crescents predict estimated glomerular filtration rate trajectory after methylprednisolone pulse therapy with tonsillectomy for IgA nephropathy

概要

Glomerular hematuria and proteinuria are typical manifestations of IgA nephropathy (IgAN). However, hematuria severity is not considered a useful marker of the potential benefits of corticosteroid administration while proteinuria severity is in the current guidelines. In this retrospective cohort study, we enrolled 133 patients diagnosed with IgAN through biopsy. We calculated the 2-year estimated glomerular filtration rate (eGFR) slope (mL/min/1.73m2/year) and eGFR trajectory after methylprednisolone pulse therapy using mixed effects models stratified by the Oxford classification and three categories of pre-treatment hematuria: mild [urinary red blood cells (URBCs) < 10/high-power field (HPF)], moderate (URBCs 10–30/HPF), and severe (URBCs ≥ 30/HPF). The severe pre-treatment hematuria group showed a significantly higher likelihood of having crescents (odds ratio, 4.3; 95% confidence interval, 1.7–10.9) at baseline. In the longitudinal analysis of 103 patients, most of whom underwent tonsillectomy, the severe pre-treatment hematuria group had a significantly higher 2-year eGFR slope after methylprednisolone pulse therapy than the mild and moderate hematuria groups (mild, -0.52±1.97; moderate, -0.32±1.99; severe, 1.44±3.20 mL/min/1.73m2/year). Patients with C2 scores showed a significantly higher 2-year eGFR slope after methylprednisolone pulse therapy than those with C0 and C1 scores (C0, -0.38±1.74; C1, 0.81±3.02; C2, 3.29±3.68 mL/min/1.73m2/year). Analyses of eGFR trajectory after methylprednisolone pulse therapy revealed that the eGFR improved only in patients with severe pre-treatment hematuria or C2 score (P for interaction with time < 0.001). Our study suggests that the eGFR is likely to improve after methylprednisolone pulse therapy with tonsillectomy in IgAN patients with severe pre- treatment hematuria or a high percentage of crescents.