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Ribosomal DNA gene copies are increased in blood and brain of Japanese schizophrenia patients

Li, Sen Otsuka, Ikuo Tanifuji, Takaki Okazaki, Satoshi Horai, Tadasu Takahashi, Motonori Kondo, Takeshi Ueno, Yasuhiro Hishimoto, Akitoyo 神戸大学

2023.01.20

概要

Past evidence has indicated increased ribosomal DNA (rDNA) content in the blood of patients with schizophrenia (SCZ) among European populations. Here, for the first time, we investigated the rDNA copy number (rDNAcn) of SCZ in East Asian populations as well as in blood and brain tissues. In this study, we measured 18S/28S rDNAcn in the peripheral blood of live participants (81 patients with SCZ and 98 healthy controls) and the dorsolateral prefrontal cortices (DLPFCs) of postmortem individuals (10 patients with SCZ and 23 non-psychiatric controls) in the Japanese population. Patients with SCZ had significantly increased 18S/28S rDNAcn in the blood compared to controls (p < 0.05). 18S rDNAcn was significantly increased in the brain of patients with SCZ compared to controls (p < 0.05). In conclusion, regarding the increased rDNAcn in the blood of patients with SCZ that was previously reported in Europeans, we successfully replicated this by using a different, ethnically East Asian, cohort. Additionally, we provide the first evidence of increased rDNAcn in the brain of patients with SCZ. These findings may help to elucidate the molecular underpinnings of SCZ pathophysiology related to ribosomal DNA abnormalities.

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参考文献

1.

Khatter H, Myasnikov AG, Natchiar SK, Klaholz BP. Structure of the human 80S ribosome. Nature.

2015; 520:640–5. https://doi.org/10.1038/nature14427 PMID: 25901680

2.

McStay B, Grummt I. The epigenetics of rRNA genes: from molecular to chromosome biology. Annu

Rev Cell Dev Biol. 2008; 24:131–57. https://doi.org/10.1146/annurev.cellbio.24.110707.175259 PMID:

18616426

3.

Warland A, Kendall KM, Rees E, Kirov G, Caseras X. Schizophrenia-associated genomic copy number

variants and subcortical brain volumes in the UK Biobank. Mol Psychiatry. 2020; 25:854–62. https://doi.

org/10.1038/s41380-019-0355-y PMID: 30679740

4.

Krzyżanowska M, Steiner J, Brisch R, Mawrin C, Busse S, Braun K, et al. Ribosomal DNA transcription

in dorsal raphe nucleus neurons is increased in residual schizophrenia compared to depressed patients

with affective disorders. Psychiatry Res. 2015; 230:233–41. https://doi.org/10.1016/j.psychres.2015.

08.045 PMID: 26350704

5.

Krzyżanowska M, Steiner J, Brisch R, Mawrin C, Busse S, Braun K, et al. Ribosomal DNA transcription

in the dorsal raphe nucleus is increased in residual but not in paranoid schizophrenia. Eur Arch Psychiatry Clin Neurosci. 2015;265117–26. https://doi.org/10.1007/s00406-014-0518-4.

6.

Veĭko NN, Egolina NA, Radzivil GG, Nurbaev SD, Kosiakova NV, Shubaeva NO, et al. [Quantitative

analysis of repetitive sequences in human genomic DNA and detection of an elevated ribosomal repeat

copy number in patients with schizophrenia (the results of molecular and cytogenetic analysis)]. Mol

Biol (Mosk). 2003; 37:409–19.

7.

Chestkov IV, Jestkova EM, Ershova ES, Golimbet VE, Lezheiko TV, Kolesina NY, et al. Abundance of

ribosomal RNA gene copies in the genomes of schizophrenia patients. Schizophr Res. 2018; 197:305–

14. https://doi.org/10.1016/j.schres.2018.01.001 PMID: 29336872

8.

Ershova ES, Malinovskaya EM, Golimbet VE, Lezheiko TV, Zakharova NV, Shmarina GV, et al. Copy

number variations of satellite III (1q12) and ribosomal repeats in health and schizophrenia. Schizophr

Res. 2020; 223:199–212. https://doi.org/10.1016/j.schres.2020.07.022 PMID: 32773342

9.

Jones SH, Thornicroft G, Coffey M, Dunn G. A brief mental health outcome scale-reliability and validity

of the global assessment of functioning (GAF). Br J Psychiatry. 1995; 166:654–9. https://doi.org/10.

1192/bjp.166.5.654 PMID: 7620753

10.

Overall JE, Gorham DR. The Brief Psychiatric Rating Scale. Psychol Rep. 1962; 10:799–812. https://

doi.org/10.2466/pr0.1962.10.3.799.

PLOS ONE | https://doi.org/10.1371/journal.pone.0280694 January 20, 2023

8/9

PLOS ONE

Ribosomal DNA gene copies in Japanese schizophrenia patients

11.

Hallgren J, Pietrzak M, Rempala G, Nelson PT, Hetman M. Neurodegeneration-associated instability of

ribosomal DNA. Biochim Biophys Acta. 2014; 1842:860–8. https://doi.org/10.1016/j.bbadis.2013.12.

012 PMID: 24389328

12.

Lam M, Chen CY, Li Z, Martin AR, Bryois J, Ma X, et al. Comparative genetic architectures of schizophrenia in East Asian and European populations. Nat Genet. 2019; 51:1670–8. https://doi.org/10.1038/

s41588-019-0512-x PMID: 31740837

13.

Krzyżanowska M, Steiner J, Brisch R, Mawrin C, Busse S, Karnecki K, et al. Decreased ribosomal DNA

transcription in dorsal raphe nucleus neurons is specific for suicide regardless of psychiatric diagnosis.

Psychiatry Res. 2016; 241:43–46. https://doi.org/10.1016/j.psychres.2016.04.079 PMID: 27155286

14.

Kahn RS, Sommer IE, Murray RM, Meyer-Lindenberg A, Weinberger DR, Cannon TD, et al. Schizophrenia. Nat Rev Dis Primers. 2015; 1:15067. https://doi.org/10.1038/nrdp.2015.67 PMID: 27189524

15.

Weinberger DR, Berman KF, Zec RF. Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence. Arch Gen Psychiatry. 1986; 43:114–24. https://doi.

org/10.1001/archpsyc.1986.01800020020004 PMID: 3947207

16.

Arnsten AFT, Woo E, Yang S, Wang M, Datta D. Unusual Molecular Regulation of Dorsolateral Prefrontal Cortex Layer III Synapses Increases Vulnerability to Genetic and Environmental Insults in Schizophrenia. Biol Psychiatry. 2022; 92:480–90. https://doi.org/10.1016/j.biopsych.2022.02.003 PMID:

35305820

17.

Hosgood HD, Hu W, Rothman N, Klugman M, Weinstein SJ, Virtamo JR, et al. Variation in ribosomal

DNA copy number is associated with lung cancer risk in a prospective cohort study. Carcinogenesis.

2019; 40:975–978. https://doi.org/10.1093/carcin/bgz052 PMID: 30859204

PLOS ONE | https://doi.org/10.1371/journal.pone.0280694 January 20, 2023

9/9

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