1.
Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A (2015) Global Cancer Statistics, 2012.
CA Cancer J Clin 65: 87. https://doi.org/10.3322/caac.21262 PMID: 25651787
2.
Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. (2015) Cancer incidence and
mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136:
E359. https://doi.org/10.1002/ijc.29210 PMID: 25220842
3.
Reimers MS, Zeestraten EC, Kuppen PJ, Liefers GJ, Velde CJ (2013) Biomarkers in precision therapy
in colorectal cancer. Gastroenterol Rep (Oxf) 1: 166.
4.
Levin B, Lieberman DA, McFarland B, Smith RA, Brooks D, Andrews KS, et al. (2008) Screening and
surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline
from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the
American College of Radiology. CA Cancer J Clin 58: 130. https://doi.org/10.3322/CA.2007.0018
PMID: 18322143
5.
Yung DE, Vijayan S, Avni T, Douglas S, Kopylov U, Koulaouzidis A (2017) Fecal occult blood testing for
the prediction of small-bowel pathology detected by capsule endoscopy: a systematic review and metaanalysis. Ann Gastroenterol 30: 186. https://doi.org/10.20524/aog.2017.0122 PMID: 28243039
6.
Issa IA, Noureddine M (2017) Colorectal cancer screening: An updated review of the available options.
World J Gastroenterol 23: 5086. https://doi.org/10.3748/wjg.v23.i28.5086 PMID: 28811705
7.
Jayanthi VSPKSA, Das AB, Saxena U (2017) Recent advances in biosensor development for the detection of cancer biomarkers. Biosens Bioelectron 91: 15. https://doi.org/10.1016/j.bios.2016.12.014
PMID: 27984706
8.
Brenner DR, Scherer D, Muir K, Schildkraut J, Boffetta P, Spitz MR, et al. (2014) A review of the application of inflammatory biomarkers in epidemiologic cancer research. Cancer Epidemiol Biomarkers Prev
23: 1729. https://doi.org/10.1158/1055-9965.EPI-14-0064 PMID: 24962838
9.
Ballaz S, Mulshine JL (2003) The potential contributions of chronic inflammation to lung carcinogenesis.
Clin Lung Cancer 5: 46. https://doi.org/10.3816/CLC.2003.n.021 PMID: 14596704
10.
Allavena P, Garlanda C, Borrello MG, Sica A, Mantovani A (2008) Pathways connecting inflammation
and cancer. Curr Opin Genet Dev 18: 3. https://doi.org/10.1016/j.gde.2008.01.003 PMID: 18325755
11.
Engels EA (2008) Inflammation in the development of lung cancer: epidemiological evidence. Expert
Rev Anticancer Ther 8: 605. https://doi.org/10.1586/14737140.8.4.605 PMID: 18402527
12.
Mantovani A, Allavena P, Sica A, Balkwill F (2008) Cancer-related inflammation. Nature 454: 436.
https://doi.org/10.1038/nature07205 PMID: 18650914
13.
Azad N, Rojanasakul Y, Vallyathan V (2008) Inflammation and lung cancer: roles of reactive oxygen/
nitrogen species. J Toxicol Environ Health B Crit Rev 11: 1. https://doi.org/10.1080/
10937400701436460 PMID: 18176884
14.
Mager LF, Wasmer MH, Rau TT, Krebs P (2016) Cytokine-Induced Modulation of Colorectal Cancer.
Front Oncol 6: 96. https://doi.org/10.3389/fonc.2016.00096 PMID: 27148488
15.
Mlecnik B, Bindea G, Angell HK, Sasso MS, Obenauf AC, Fredrikse T, et al. (2014) Functional network
pipeline reveals genetic determinants associated with in situ lymphocyte proliferation and survival of
cancer patients. Sci Transl Med 6: 228.
16.
Itatani Y, Kawada K, Inamoto S, Yamamoto T, Ogawa R, Taketo MM, et al. (2016) The Role of Chemokines in Promoting Colorectal Cancer Invasion/Metastasis. Int J Mol Sci 17: 643.
17.
Machida-Montani A, Sasazuki S, Inoue M, Natsukawa S, Shaura K, Koizumi Y, et al. (2007) Atrophic
gastritis, Helicobacter pylori, and colorectal cancer risk: a case-control study. Helicobacter 12: 328.
https://doi.org/10.1111/j.1523-5378.2007.00513.x PMID: 17669106
18.
Daly S, Rinewalt D, Fhied C, Basu S, Mahon B, Liptay MJ, et al. (2013) Development and validation of a
plasma biomarker panel for discerning clinical significance of indeterminate pulmonary nodules. J
Thorac Oncol: IASLC 8: 31.
19.
DeCotiis C, Hu Y, Greenberg AK, Huie M, Tsay JJ, Pass H, et al. (2016) Inflammatory cytokines and
non-small cell lung cancer in a CT-scan screening cohort: Background review of the literature. Cancer
Biomark 16: 219. https://doi.org/10.3233/CBM-150559 PMID: 26756613
20.
Kezic S, O’Regan GM, Lutter R, Jakasa I, Koster ES, Saunders S, et al. (2012) Filaggrin loss-of-function
mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients
with atopic dermatitis and in a murine model of filaggrin deficiency. J Allergy Clin Immunol 129: 1031.
https://doi.org/10.1016/j.jaci.2011.12.989 PMID: 22322004
21.
Attur M, Wang H-Y, Kraus VB, Bukowski J, Aziz N, Krasnokutsky S, et al. (2010) Radiographic severity
of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations. Ann Rheum Dis
69: 856. https://doi.org/10.1136/ard.2009.113043 PMID: 19934104
PLOS ONE | https://doi.org/10.1371/journal.pone.0213602 March 18, 2019
11 / 13
Plasma cytokine levels of colorectal cancer
22.
Kleinbaum DG, Klein M (2010) Logistic Regression. 3rd ed. New York: Springer Science+Business
Media LCC.
23.
DeLong ER, DeLong DM, Clarke-Pearson DL (1988) Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 44: 837. PMID:
3203132
24.
Torres S, Bartolome RA, Mendes M, Barderas R, Fernandez-Aceñero MJ, Pela´ez-Garcı´a A, et al.
(2013) Proteome profiling of cancer-associated fibroblasts identifies novel proinflammatory signatures
and prognostic markers for colorectal cancer. Clin Cancer Res 19: 6006. https://doi.org/10.1158/10780432.CCR-13-1130 PMID: 24025712
25.
Kantola T, Klintrup K, Va¨yrynen JP, Vornanen J, Bloigu R, Karhu T, et al. (2012) Stage-dependent alterations of the serum cytokine pattern in colorectal carcinoma. Br J Cancer 107: 1729. https://doi.org/10.
1038/bjc.2012.456 PMID: 23059742
26.
Szylberg Ł, Janiczek M, Popiel A, Marszatek A (2016) Expression of COX-2, IL-1β, TNF-α and IL-4 in
epithelium of serrated adenoma, adenoma and hyperplastic polyp. Arch Med Sci 12: 172. https://doi.
org/10.5114/aoms.2016.57594 PMID: 26925134
27.
Sharp SP, Avram D, Stain SC, Lee EC (2017) Local and systemic Th17 immune response associated
with advanced stage colon cancer. J Surg Res 208: 180. https://doi.org/10.1016/j.jss.2016.09.038
PMID: 27993206
28.
Johdi NA, Mazlan L, Sagap I, Jamal R (2017) Profiling of cytokines, chemokines and other soluble proteins as a potential biomarker in colorectal cancer and polyps. Cytokine 99: 35. https://doi.org/10.1016/
j.cyto.2017.06.015 PMID: 28689023
29.
Cheadle EJ, Riyad K, Subar D, Rothwell DG, Ashton G, Batha H, et al. (2007) Eotaxin-2 and colorectal
cancer: a potential target for immune therapy. Clin Cancer Res 13: 5719. https://doi.org/10.1158/10780432.CCR-07-1145 PMID: 17908961
30.
Fujisawa T, Kato Y, Atsuta J, Terada A, Iguchi K, Kamiya H, et al. (2000) Chemokine production by the
BEAS-2B human bronchial epithelial cells: differential regulation of eotaxin, IL-8, and RANTES by TH2and TH1-derived cytokines. J Allergy Clin Immunol 105: 126. PMID: 10629462
31.
Natori T, Sata M, Washida M, Hirata Y, Nagai R, Makuuchi M (2002) G-CSF stimulates angiogenesis
and promotes tumor growth: potential contribution of bone marrow-derived endothelial progenitor cells.
Biochem Biophys Res Commun 297: 1058. PMID: 12359263
32.
Mroczko B, Groblewska M, Wereszczynska-Siemiatkowska U, Kedra B, Konopko M, Szmitkowksi M
(2006) The diagnostic value of G-CSF measurement in the sera of colorectal cancer and adenoma
patients. Clin Chim Acta 371: 143. https://doi.org/10.1016/j.cca.2006.02.037 PMID: 16603145
33.
Crucitti A, Corbi M, Tomaiuolo PM, Fanali C, Mazzari A, Lucchetti D, et al. (2015) Laparoscopic surgery for
colorectal cancer is not associated with an increase in the circulating levels of several inflammation-related
factors. Cancer Biol Ther 16: 671. https://doi.org/10.1080/15384047.2015.1026476 PMID: 25875151
34.
Kraus S, Arber N (2009) Inflammation and colorectal cancer. Curr Opin Pharmacol 9: 405. https://doi.
org/10.1016/j.coph.2009.06.006 PMID: 19589728
35.
Ullman TA, Itzkowitz SH (2011) Intestinal inflammation and cancer. Gastroenterology 140: 1807.
https://doi.org/10.1053/j.gastro.2011.01.057 PMID: 21530747
36.
Kamińska J, Kowalska MM, Nowacki MP, Chwaliński MG, Rysińska A, Fuksiewicz M (2000) CRP,
TNF-alpha, IL-1ra, IL-6, IL-8 and IL-10 in blood serum of colorectal cancer patients. Pathol Oncol Res
6: 38. PMID: 10749586
37.
Szkaradkiewicz A, Marciniak R, Chudzicka-Strugała I, Wasilewska A, Drews M, Majewski P, et al.
(2009) Proinflammatory cytokines and IL-10 in inflammatory bowel disease and colorectal cancer
patients. Arch Immunol Ther Exp (Warsz) 57: 291.
38.
Dimberg J, Stro¨m K, Lo¨fgren S, Zar N, Lindh M, Matussek A (2012) DNA promoter methylation status
and protein expression of interleukin-8 in human colorectal adenocarcinomas. Int J Colorectal Dis 27:
709. https://doi.org/10.1007/s00384-011-1367-5 PMID: 22108905
39.
Crucitti A, Corbi M, Tomaiuolo PM, Fanali C, Mazzari A, Lucchetti D, et al. (2015) Laparoscopic surgery
for colorectal cancer is not associated with an increase in the circulating levels of several inflammationrelated factors. Cancer Biol Ther 16: 671. https://doi.org/10.1080/15384047.2015.1026476 PMID:
25875151
40.
Bai M, Chen X, Ba YI (2016) CXCL10/CXCR3 overexpression as a biomarker of poor prognosis in
patients with stage II colorectal cancer. Mol Clin Oncol 4: 23. https://doi.org/10.3892/mco.2015.665
PMID: 26870351
41.
Johdi NA, Mazlan L, Sagap I, Jamal R (2017) Profiling of cytokines, chemokines and other soluble proteins as a potential biomarker in colorectal cancer and polyps. Cytokine 99: 35. https://doi.org/10.1016/
j.cyto.2017.06.015 PMID: 28689023
PLOS ONE | https://doi.org/10.1371/journal.pone.0213602 March 18, 2019
12 / 13
Plasma cytokine levels of colorectal cancer
42.
Carson RT, Vignali DA (1999) Simultaneous quantitation of 15 cytokines using a multiplexed flow cytometric assay. J Immunol Methods 227: 41. PMID: 10485253
43.
Prabhakar U, Eirikis E, Davis HM (2002) Simultaneous quantification of proinflammatory cytokines in
human plasma using the LabMAP assay. J Immunol Methods 260: 207. PMID: 11792390
44.
de Jager W, te Velthuis H, Prakken BJ, Kuis W, Rijkers GT (2003) Simultaneous detection of 15 human
cytokines in a single sample of stimulated peripheral blood mononuclear cells. Clin Diagn Lab Immunol
10: 133. https://doi.org/10.1128/CDLI.10.1.133-139.2003 PMID: 12522051
45.
Ray CA, Bowsher RR, Smith WC, Devanarayan V, Willey MB, Brandt JT, et al. (2005) Development,
validation, and implementation of a multiplex immunoassay for the simultaneous determination of five
cytokines in human serum. J Pharm Biomed Anal 36: 1037. https://doi.org/10.1016/j.jpba.2004.05.024
PMID: 15620530
46.
Crucitti A, Corbi M, Tomaiuolo PMC, Fanali C, Mazzari A, Lucchetti D, Migaldi M, Sgambato A (2015)
Laparoscopic surgery for colorectal cancer is not associated with an increase in the circulating levels of
several inflammation-related factors. Cancer Biol Ther 16: 671. https://doi.org/10.1080/15384047.
2015.1026476 PMID: 25875151
47.
Li Y, Qiu Q, Fan Z, He P, Chen H, Jiao X (2018) Th17 cytokine profiling of colorectal cancer patients
with or without enterovirus 71 antigen expression. Cytokine 107: 35. https://doi.org/10.1016/j.cyto.
2017.11.012 PMID: 29175261
PLOS ONE | https://doi.org/10.1371/journal.pone.0213602 March 18, 2019
13 / 13
...