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Identification of sur2 mutation affecting the lifespan of fission yeast

Kurauchi, Tatsuhiro Matsui, Kotaro Shimasaki, Takafumi Ohtsuka, Hokuto Tsubouchi, Satoshi Ihara, Kunio Tani, Motohiro Aiba, Hirofumi 名古屋大学

2021.06.10

概要

Yeast is a suitable model system to analyze the mechanism of lifespan. In this study, to identify novel factors involved in chronological lifespan, we isolated a mutant with a long chronologically lifespan and found a missense mutation in the sur2+ gene, which encodes a homolog of S. cerevisiae sphingolipid C4-hydroxylase in fission yeast. Characterization of the mutant revealed that loss of sur2 function resulted in an extended chronological life span. The effect of caloric restriction, a well-known signal for extending lifespan, is thought to be dependent on the sur2+ gene.

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参考文献

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