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7.
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10.
11.
12.
13.
14.
15.
16.
17.
18.
19.
20.
21.
22.
23.
24.
25.
26.
27.
28.
29.
Stirban, A.; Lentrodt, S.; Nandrean, S.; Pop, A.; Tschoepe, D.; Scherbaum, W.A. Functional Changes in Microcirculation during
Hyperbaric and Normobaric Oxygen Therapy. Undersea Hyperb. Med. 2009, 36, 381–390. [PubMed]
Bhutani, S.; Vishwanath, G. Hyperbaric Oxygen and Wound Healing. Indian J. Plast. Surg. 2012, 45, 316–324. [CrossRef] [PubMed]
Akarsu, S.; Tekin, L.; Ay, H.; Çarli, A.B.; Tok, F.; S¸ im¸sek, K.; Kiralp, M.Z. The Efficacy of Hyperbaric Oxygen Therapy in the
Management of Chronic Fatigue Syndrome. Undersea Hyperb. Med. 2013, 40, 197–200.
Demchenko, I.T.; Zhilyaev, S.Y.; Moskvin, A.N.; Krivchenko, A.I.; Piantadosi, C.A.; Allen, B.W. Baroreflex-Mediated Cardiovascular Responses to Hyperbaric Oxygen. J. Appl. Physiol. 2013, 115, 819–828. [CrossRef]
Heitkemper, M.; Burr, R.L.; Jarrett, M.; Hertig, V.; Lustyk, M.K.; Bond, E.F. Evidence for Autonomic Nervous System Imbalance in
Women with Irritable Bowel Syndrome. Dig. Dis. Sci. 1998, 43, 2093–2098. [CrossRef] [PubMed]
Martinez-Lavin, M.; Hermosillo, A.G. Autonomic Nervous System Dysfunction May Explain the Multisystem Features of
Fibromyalgia. Semin. Arthritis Rheum. 2000, 29, 197–199. [CrossRef]
Ilagan, R.; Winarski, M.; Lagina, A. Indications for Emergent Hyperbaric Oxygen Therapy. Curr. Emerg. Hosp. Med. Rep. 2022, 10,
134–142. [CrossRef]
Hamilton-Farrell, M.; Bhattacharyya, A. Barotrauma. Injury 2004, 35, 359–370. [CrossRef]
Narkowicz, C.K.; Vial, J.H.; Mccartney, P.W. Hyperbaric Oxygen Therapy Increases Free Radical Levels in the Blood of Humans.
Free Radic. Res. Commun. 1993, 19, 71–80. [CrossRef]
Moon, R.E.; Camporesi, E.M. Respiratory Monitoring. In Anesthesia, 5th ed.; Elsevier Churchill Livingstone: Philadelphia, PA,
USA, 2000; pp. 1255–1295.
Plafki, C.; Peters, P.; Almeling, M.; Welslau, W.; Busch, R. Complications and Side Effects of Hyperbaric Oxygen Therapy. Aviat.
Space Environ. Med. 2000, 71, 119–124. [PubMed]
Heyboer, M. Hyperbaric Oxygen Therapy Side Effects—Where Do We Stand? J. Am. Coll. Clin. Wound Spec. 2016, 8, 2–3. [CrossRef]
Thom, S.R. Oxidative Stress Is Fundamental to Hyperbaric Oxygen Therapy. J. Appl. Physiol. 2009, 106, 988–995. [CrossRef] [PubMed]
Dennog, C.; Hartmann, A.; Frey, G.; Speit, G. Detection of DNA Damage after Hyperbaric Oxygen (HBO) Therapy. Mutagenesis
1996, 11, 605–609. [CrossRef] [PubMed]
Ishihara, A. Mild Hyperbaric Oxygen: Mechanisms and Effects. J. Physiol. Sci. 2019, 69, 573–580. [CrossRef] [PubMed]
Takemura, A.; Ishihara, A. Mild Hyperbaric Oxygen Inhibits Growth-Related Decrease in Muscle Oxidative Capacity of Rats with
Metabolic Syndrome. J. Atheroscler. Thromb. 2017, 24, 26–38. [CrossRef] [PubMed]
Yasuda, K.; Aoki, N.; Adachi, T.; Tsujimoto, G.; Gu, N.; Matsunaga, T.; Kikuchi, N.; Tsuda, K.; Ishihara, A. Hyperbaric Exposure
with High Oxygen Concentration Inhibits Growth-Associated Increase in the Glucose Level of Diabetic Goto-Kakizaki Rats.
Diabetes Obes. Metab. 2006, 8, 714–715. [CrossRef]
Nagatomo, F.; Fujino, H.; Takeda, I.; Ishihara, A. Effects of Hyperbaric Oxygenation on Blood Pressure Levels of Spontaneously
Hypertensive Rats. Clin. Exp. Hypertens. 2010, 32, 193–197. [CrossRef]
Ishihara, A.; Nagatomo, F.; Fujino, H.; Kondo, H. Exposure to Mild Hyperbaric Oxygen Increases Blood Flow and Resting Energy
Expenditure but Not Oxidative Stress. J. Sci. Res. Rep. 2014, 3, 1886–1896. [CrossRef]
Nisa, B.U.; Hirabayashi, T.; Maeshige, N.; Kondo, H.; Fujino, H. Beneficial Effects of Mild Hyperbaric Oxygen Exposure on
Microcirculation in Peripheral Tissues in Healthy Subjects: Pilot Study. J. Sports Med. Phys. Fit. 2022, 62, 1600–1604. [CrossRef]
Kenney, M.J.; Ganta, C.K. Autonomic Nervous System and Immune System Interactions. Compr. Physiol. 2014, 4, 1177–1200. [CrossRef]
Rinner, I.; Felsner, P.; Falus, A.; Skreiner, E.; Kukulansky, T.; Globerson, A.; Hirokawa, K.; Schauenstein, K. Cholinergic Signals to
and from the Immune System. Immunol. Lett. 1995, 44, 217–220. [CrossRef] [PubMed]
Ulloa, L. The Vagus Nerve and the Nicotinic Anti-Inflammatory Pathway. Nat. Rev. Drug Discov. 2005, 4, 673–684. [CrossRef]
van Erp, E.A.; van Kampen, M.R.; van Kasteren, P.B.; de Wit, J. Viral Infection of Human Natural Killer Cells. Viruses 2019,
11, 243. [CrossRef]
Morimoto, K.; Takeshita, T.; Inoue-Sakurai, C.; Maruyama, S. Lifestyles and Mental Health Status Are Associated with Natural
Killer Cell and Lymphokine-Activated Killer Cell Activities. Sci. Total Environ. 2001, 270, 3–11. [CrossRef]
Inoue, C.; Takeshita, T.; Kondo, H.; Morimoto, K. Cigarette Smoking Is Associated with the Reduction of Lymphokine-Activated
Killer Cell and Natural Killer Cell Activities. Environ. Health Prev. Med. 1996, 1, 14–19. [CrossRef] [PubMed]
Daniela, M.; Catalina, L.; Ilie, O.; Paula, M.; Daniel-Andrei, I.; Ioana, B. Effects of Exercise Training on the Autonomic Nervous
System with a Focus on Anti-Inflammatory and Antioxidants Effects. Antioxidants 2022, 11, 350. [CrossRef] [PubMed]
Moldoveanu, A.I.; Shephard, R.J.; Shek, P.N. The Cytokine Response to Physical Activity and Training. Sports Med. 2001, 31,
115–144. [CrossRef] [PubMed]
Krog, J.; Tønnesen, E.; Jepsen, C.F.; Parner, E.; Segadal, K.; Hope, A.; Ulvik, R.J.; Hokland, M.E. Natural Killer Cells as Biomarkers
of Hyperbaric Stress During a Dry Heliox Saturation Dive. Aviat. Space Environ. Med. 2010, 81, 467–474. [CrossRef] [PubMed]
Life 2023, 13, 408
30.
31.
32.
33.
34.
35.
36.
37.
38.
39.
40.
41.
42.
43.
44.
45.
46.
47.
48.
49.
50.
51.
52.
12 of 13
Dupont, W.D.; Plummer, W.D. Power and Sample Size Calculations: A Review and Computer Program. Control. Clin. Trials 1990,
11, 116–128. [CrossRef]
Evans, S.R. Clinical Trial Structures. J. Exp. Stroke Transl. Med. 2010, 3, 8. [CrossRef]
Omagari, K.; Kumamoto, R.; Koyama, Y.; Suzuta, M.; Taniguchi, A.; Fukuda, A.; Iwami, M.; Koba, K.; Kawaguchi, A.; Otsuka, K.
Prevalence of Chronic Constipation and Irritable Bowel Syndrome, and Their Overlap, among Female Undergraduate Students
in Japan. OBM Hepatol. Gastroenterol. 2020, 4, 18. [CrossRef]
Chang, W.L.; Hou, C.J.Y.; Wei, S.P.; Tsai, J.P.; Chen, Y.J.; Chen, M.L.; Chuech, C.C.; Hung, C.L.; Huang, M.Y.; Lee, C.H.; et al.
Utilization and Clinical Feasibility of a Handheld Remote Electrocardiography Recording Device in Cardiac Arrhythmias and
Atrial Fibrillation: A Pilot Study. Int. J. Gerontol. 2015, 9, 206–210. [CrossRef]
Morimoto, M.; Satomura, S.; Hashimoto, T.; Ito, E.; Kyotani, S. Oxidative Stress Measurement and Prediction of Epileptic Seizure
in Children and Adults with Severe Motor and Intellectual Disabilities. J. Clin. Med. Res. 2016, 8, 437–444. [CrossRef] [PubMed]
Van Beaumont, W. Evaluation of Hemoconcentration from Hematocrit Measurements. J. Appl. Physiol. 1972, 32, 712–713.
[CrossRef] [PubMed]
Teixeira, A.d.O.; Franco, O.S.; Borges, M.M.; Martins, C.N.; Guerreiro, L.F.; da Rosa, C.E.; Paulitsch, F.d.S.; Perez, W.; da Silva,
A.M.V.; Signori, L.U. The Importance of Adjustments for Changes in Plasma Volume in the Interpretation of Hematological and
Inflammatory Responses after Resistance Exercise. J. Exerc. Physiol. Online 2014, 17, 72–83.
Sherk, V.D.; Chrisman, C.; Smith, J.; Young, K.C.; Singh, H.; Bemben, M.G.; Bemben, D.A. Acute Bone Marker Responses to
Whole-Body Vibration and Resistance Exercise in Young Women. J. Clin. Densitom. 2013, 16, 104–109. [CrossRef]
Heyboer, M.; Milovanova, T.N.; Wojcik, S.; Grant, W.; Chin, M.; Hardy, K.R.; Lambert, D.S.; Logue, C.; Thom, S.R. CD34+/CD45Dim Stem Cell Mobilization by Hyperbaric Oxygen—Changes with Oxygen Dosage. Stem Cell Res. 2014, 12, 638–645. [CrossRef]
Hadanny, A.; Efrati, S. The Hyperoxic-Hypoxic Paradox. Biomolecules 2020, 10, 958. [CrossRef]
Shandley, S.; Wolf, E.G.; Schubert-Kappan, C.M.; Baugh, L.M.; Richards, M.F.; Prye, J.; Arizpe, H.M.; Kalns, J. Increased Circulating
Stem Cells and Better Cognitive Performance in Traumatic Brain Injury Subjects following Hyperbaric Oxygen Therapy. Undersea
Hyperb. Med. 2017, 44, 257–269. [CrossRef]
Hehenberger, K.; Brismar, K.; Lind, F.; Kratz, G. Dose-Dependent Hyperbaric Oxygen Stimulation of Human Fibroblast Proliferation. Wound Repair Regen. 1997, 5, 147–150. [CrossRef]
Sahni, T.; Hukku, S.; Jain, M.; Prasad, A.; Prasad, R.; Singh, K. Recent Advances in Hyperbaric Oxygen Therapy. Med. Updat.
2004, 14, 632–639.
Mori, H.; Nishijo, K.; Kawamura, H.; Abo, T. Unique Immunomodulation by Electro-Acupuncture in Humans Possibly via
Stimulation of the Autonomic Nervous System. Neurosci. Lett. 2002, 320, 21–24. [CrossRef]
Mathieu, D.; Favory, R.; Collet, F.; Linke, J.-C.; Wattel, F. Physiologic Effects of Hyperbaric Oxygen on Hemodynamics and
Microcirculation. In Handbook on Hyperbaric Medicine; Mathieu, D., Ed.; Springer: Dordrecht, The Netherlands, 2006; pp. 75–101,
ISBN 978-1-4020-4448-9.
Chateau-Degat, M.L.; Belley, R. Hyperbaric Oxygen Therapy Decreases Blood Pressure in Patients with Chronic Wounds. Undersea
Hyperb. Med. 2012, 39, 881.
Capellino, S.; Claus, M.; Watzl, C. Regulation of Natural Killer Cell Activity by Glucocorticoids, Serotonin, Dopamine, and
Epinephrine. Cell. Mol. Immunol. 2020, 17, 705–711. [CrossRef] [PubMed]
Poli, A.; Michel, T.; Thérésine, M.; Andrès, E.; Hentges, F.; Zimmer, J. CD56brightnatural Killer (NK) Cells: An Important NK Cell
Subset. Immunology 2009, 126, 458–465. [CrossRef] [PubMed]
de Wolde, S.D.; Hulskes, R.H.; de Jonge, S.W.; Hollmann, M.W.; van Hulst, R.A.; Weenink, R.P.; Kox, M. The Effect of Hyperbaric
Oxygen Therapy on Markers of Oxidative Stress and the Immune Response in Healthy Volunteers. Front. Physiol. 2022,
13, 826163. [CrossRef]
Valko, M.; Leibfritz, D.; Moncol, J.; Cronin, M.T.D.; Mazur, M.; Telser, J. Free Radicals and Antioxidants in Normal Physiological
Functions and Human Disease. Int. J. Biochem. Cell Biol. 2007, 39, 44–84. [CrossRef]
Hedetoft, M.; Garred, P.; Madsen, M.B.; Hyldegaard, O. Hyperbaric Oxygen Treatment Is Associated with a Decrease in Cytokine
Levels in Patients with Necrotizing Soft-Tissue Infection. Physiol. Rep. 2021, 9, e14757. [CrossRef]
Bosco, G.; Vezzani, G.; Mrakic Sposta, S.; Rizzato, A.; Enten, G.; Abou-samra, A.; Malacrida, S.; Quartesan, S.; Vezzoli, A.;
Camporesi, E. Hyperbaric Oxygen Therapy Ameliorates Osteonecrosis in Patients by Modulating Inflammation and Oxidative
Stress. J. Enzym. Inhib. Med. Chem. 2018, 33, 1501–1505. [CrossRef]
Watford, W.T.; Moriguchi, M.; Morinobu, A.; O’Shea, J.J. The Biology of IL-12: Coordinating Innate and Adaptive Immune
Responses. Cytokine Growth Factor Rev. 2003, 14, 361–368. [CrossRef]
Life 2023, 13, 408
53.
54.
13 of 13
Hartmann, G.; Tschöp, M.; Fischer, R.; Bidlingmaier, C.; Riepl, R.; Tschöp, K.; Hautmann, H.; Endres, S.; Toepfer, M. High
Altitude Increases Circulating Interleukin-6, Interleukin-1 Receptor Antagonist and c-Reactive Protein. Cytokine 2000, 12, 246–252.
[CrossRef] [PubMed]
Del Valle-Mendoza, J.; Tarazona-Castro, Y.; Merino-Luna, A.; Carrillo-Ng, H.; Kym, S.; Aguilar-Luis, M.A.; del Valle, L.J.;
Aquino-Ortega, R.; Martins-Luna, J.; Peña-Tuesta, I.; et al. Comparison of Cytokines Levels among COVID-19 Patients Living at
Sea Level and High Altitude. BMC Infect. Dis. 2022, 22, 96. [CrossRef] [PubMed]
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