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The hypotaurine-taurine pathway as an antioxidative mechanism in patients with acute liver failure (本文)

溝田, 高聖 慶應義塾大学

2022.03.07

概要

The liver has been thought to protect against oxidative stress through mechanisms involving reduced glutathione (GSH) that consumes high-energy phosphor-nucleotides on its synthesis. However, hepatoprotective mechanisms in acute liver failure (ALF) where the phosphor-nucleotides are decreased in remain to be solved. Liver tissues were collected from patients with ALF and liver cirrhosis (LC) and living donors (HD) who had undergone liver transplantation. Tissues were used for metabolomic analyses to determine metabolites belonging to the central carbon metabolism, and to determine sulfur-containing metabolites. ALF and LC exhibited a significant decline in metabolites of glycolysis and pentose phosphate pathways and high-energy phosphornucleotides such as adenosine triphosphate as compared with HD. Conversely, methionine, S-adenosyl-L-methionine, and the ratio of serine to 3-phosphoglycerate were elevated significantly in ALF as compared with LC and HD, suggesting a metabolic boost from glycolysis towards trans-sulfuration. Notably in ALF, the increases in hypotaurine (HTU) + taurine (TU) coincided with decreases in the total amounts of reduced and oxidized glutathione (GSH + 2GSSG). Plasma NH3 levels correlated with the ratio of HTU + TU to GSH + 2GSSG. Increased tissue levels of HTU + TU vs total glutathione appear to serve as a biomarker correlating with hyperammonemia, suggesting putative roles of the HTU-TU pathway in anti-oxidative protective mechanisms.

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参考文献

1 Oshima G, Shinoda M, Tanabe M, et al. Increased plasma levels of high mobility group box 1 in patients with acute liver failure. Eur Surg Res 2012; 48: 154–162.

2 Fujiwara K, Mochida S, Matsui A, et al. Fulminant hepatitis and late onset hepatic failure in Japan. Hepatol Res 2008; 38: 646–657.

3 McGill MR, Jaeschke H. Oxidative stress in acute liver failure. In: Albano E, Parola M, eds. Studies on Hepatic Disorders, New Jersey: Humana Press, 2015; 199–214.

4 Chen Y, Dong H, Thompson DC, Shertzer HG, Nebert DW, Vasiliou V. Glutathione defence mechanism in liver injury: insights from animal models. Food Chem Toxicol 2013; 60: 38–44.

5 Feng B, Wu S, Liu F, Gao Y, Dong F, Wei L. Metabonomic analysis of liver tissue from BALB/c mice with d-galactosamine/lipopolysaccharide-induced acute hepatic failure. BMC Gastroenterol 2013; 13: 73.

6 Feng B, Wu SM, Lv S, et al. A novel scoring system for prognostic prediction in d-galactosamine/lipopolysaccharide-induced fulminant hepatic failure BALB/c mice. BMC Gastroenterol 2009; 9: 99.

7 Sakuragawa T, Hishiki T, Ueno Y, et al. Hypotaurine is an energy-saving hepatoprotective compound against ischemia-reperfusion injury of the rat liver. J Clin Biochem Nutr 2010; 46: 126–134.

8 Soga T, Baran R, Suematsu M, et al. Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption. J Biol Chem 2006; 281: 16768–16776.

9 Takahashi Y, Shimizu M. Aetiology and prognosis of fulminant viral hepatitis in Japan: a multicentre study. The Study Group of Fulminant Hepatitis. J Gastroenterol Hepatol 1991; 6: 159–164.

10 Trey C. The fulminant hepatic failure surveillance study. Brief review of the effects of presumed etiology and age of survival. Can Med Assoc J 1972; 106 (Spec Issue): 525–528.

11 Shinoda M, Tanabe M, Itano O, et al. Left-side hepatectomy in living donors: through a reduced upper-midline incision for liver transplantation. Transplant Proc 2014; 46: 1400–1406.

12 Kamath PS, Kim WR; Advanced Liver Disease Study Group. The model for end-stage liver disease (MELD). Hepatology 2007; 45: 797–805.

13 Kamath PS, Wiesner RH, Malinchoc M, et al. A model to predict survival in patients with end-stage liver disease. Hepatology 2001; 33: 464–470.

14 Yamazoe S, Naya M, Shiota M, et al. Large-area surface-enhanced Raman spectroscopy imaging of brain ischemia by gold nanoparticles grown on random nanoarrays of transparent boehmite. ACS Nano 2014; 8: 5622–5632.

15 Yamamoto T, Takano N, Ishiwata K, et al. Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway. Nat Commun 2014; 5: 3480.

16 Takenouchi T, Sugiura Y, Morikawa T, et al. Therapeutic hypothermia achieves neuroprotection via a decrease in acetylcholine with a concurrent increase in carnitine in the neonatal hypoxia-ischemia. J Cereb Blood Flow Metab 2015; 35: 794–805.

17 Shintani T, Iwabuchi T, Soga T, et al. Cystathionine beta-synthase as a carbon monoxide-sensitive regulator of bile excretion. Hepatology 2009; 49: 141–150.

18 Morikawa T, Kajimura M, Nakamura T, et al. Hypoxic regulation of the cere‐ bral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway. Proc Natl Acad Sci U S A 2012; 109: 1293–1298.

19 Matsuhashi T, Hishiki T, Zhou H, et al. Activation of pyruvate dehydroge‐ nase by dichloroacetate has the potential to induce epigenetic remodeling in the heart. J Mol Cell Cardiol 2015; 82: 116–124.

20 Hattori K, Kajimura M, Hishiki T, et al. Paradoxical ATP elevation in ischemic penumbra revealed by quantitative imaging mass spectrometry. Antioxid Redox Signal 2010; 13: 1157–1167.

21 Clemmesen JO, Kondrup J, Ott P. Splanchnic and leg exchange of amino acids and ammonia in acute liver failure. Gastroenterology 2000; 118: 1131– 1139.

22 Shiota M, Naya M, Yamamoto T, et al. Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival. Nat Commun 2018; 9: 1561.

23 Nie CY, Han T, Zhang L, et al. Cross-sectional and dynamic change of serum metabolite profiling for Hepatitis B-related acute-on-chronic liver failure by UPLC/MS. J Viral Hepat 2014; 21: 53–63.

24 Couto N, Malys N, Gaskell SJ, Barber J. Partition and turnover of glutathione reductase from Saccharomyces cerevisiae: a proteomic approach. J Proteome Res 2013; 12: 2885–2894.

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