Valorization of Lignin and Its Derivatives Using Yeast

1. Singh, N.; Singhania, R.R.; Nigam, P.S.; Dong, C.-D.; Patel, A.K.; Puri, M. Global Status of Lignocellulosic Biorefinery: Challenges and Perspectives. Bioresour. Technol. 2022, 344, 126415. [CrossRef] [PubMed]

2. Matsushita, Y. Conversion of Technical Lignins to Functional Materials with Retained Polymeric Properties. J. Wood Sci. 2015, 61, 230–250. [CrossRef]

3. Sivagurunathan, P.; Raj, T.; Mohanta, C.S.; Semwal, S.; Satlewal, A.; Gupta, R.P.; Puri, S.K.; Ramakumar, S.S.V.; Kumar, R. 2G Waste Lignin to Fuel and High Value-Added Chemicals: Approaches, Challenges and Future Outlook for Sustainable Development. Chemosphere 2021, 268, 129326. [CrossRef] [PubMed]

4. Chauhan, P.S.; Agrawal, R.; Satlewal, A.; Kumar, R.; Gupta, R.P.; Ramakumar, S.S.V. Next Generation Applications of Lignin Derived Commodity Products, Their Life Cycle, Techno-Economics and Societal Analysis. Int. J. Biol. Macromol. 2022, 197, 179–200. [CrossRef] [PubMed]

5. Amore, A.; Ciesielski, P.N.; Lin, C.-Y.; Salvachúa, D.; Sànchez i Nogué, V. Development of Lignocellulosic Biorefinery Technologies: Recent Advances and Current Challenges. Aust. J. Chem. 2016, 69, 1201. [CrossRef]

6. Poveda-Giraldo, J.A.; Solarte-Toro, J.C.; Cardona Alzate, C.A. The Potential Use of Lignin as a Platform Product in Biorefineries: A Review. Renew Sustain. Energy Rev. 2021, 138, 110688. [CrossRef]

7. Zhang, C. Lignocellulosic Ethanol: Technology and Economics. In Alcohol Fuels-Current Technologies and Future Prospect; Yun, Y., Ed.; IntechOpen: London, UK, 2019. [CrossRef]

8. Nguyen, L.T.; Phan, D.-P.; Sarwar, A.; Tran, M.H.; Lee, O.K.; Lee, E.Y. Valorization of Industrial Lignin to Value-Added Chemicals by Chemical Depolymerization and Biological Conversion. Ind. Crops Prod. 2021, 161, 113219. [CrossRef]

9. Chatel, G.; Rogers, R.D. Review: Oxidation of Lignin Using Ionic Liquids—An Innovative Strategy to Produce Renewable Chemicals. ACS Sustain. Chem. Eng. 2014, 2, 322–339. [CrossRef]

10. De Gonzalo, G.; Colpa, D.I.; Habib, M.H.M.; Fraaije, M.W. Bacterial Enzymes Involved in Lignin Degradation. J. Biotechnol. 2016, 236, 110–119. [CrossRef]

11. Schuetz, M.; Benske, A.; Smith, R.A.; Watanabe, Y.; Tobimatsu, Y.; Ralph, J.; Demura, T.; Ellis, B.; Samuels, A.L. Laccases Direct Lignification in the Discrete Secondary Cell Wall Domains of Protoxylem. Plant. Physiol. 2014, 166, 798–807. [CrossRef] [PubMed]

12. Liu, Q.; Luo, L.; Zheng, L. Lignins: Biosynthesis and Biological Functions in Plants. Int. J. Mol. Sci. 2018, 19, 335. [CrossRef]

13. Galbe, M.; Wallberg, O. Pretreatment for Biorefineries: A Review of Common Methods for Efficient Utilisation of Lignocellulosic Materials. Biotechnol. Biofuels 2019, 12, 294. [CrossRef]

14. Aftab, M.N.; Iqbal, I.; Riaz, F.; Karadag, A.; Tabatabaei, M. Different Pretreatment Methods of Lignocellulosic Biomass for Use in Biofuel Production. In Biomass for Bioenergy-Recent Trends and Future Challenges; Abomohra, A.E., Ed.; IntechOpen: London, UK, 2019. [CrossRef]

15. Zhou, N.; Thilakarathna, W.P.D.W.; He, Q.S.; Rupasinghe, H.P.V. A Review: Depolymerization of Lignin to Generate High-Value Bio-Products: Opportunities, Challenges, and Prospects. Front. Energy Res. 2022, 9, 758744. [CrossRef]

16. Xu, C.; Ferdosian, F. Conversion of Lignin into Bio-Based Chemicals and Materials; Springer: Berlin/Heidelberg, Germany, 2017; ISBN 978-3-662-54957-5.

17. Bajwa, D.S.; Pourhashem, G.; Ullah, A.H.; Bajwa, S.G. A Concise Review of Current Lignin Production, Applications, Products and Their Environmental Impact. Ind. Crops Prod. 2019, 139, 111526. [CrossRef]

18. Grossman, A.; Vermerris, W. Lignin-Based Polymers and Nanomaterials. Curr. Opin. Biotechnol. 2019, 56, 112–120. [CrossRef]

19. Taherzadeh, M.J.; Eklund, R.; Gustafsson, L.; Niklasson, C.; Lidén, G. Characterization and Fermentation of Dilute-Acid Hydrolyzates from Wood. Ind. Eng. Chem. Res. 1997, 36, 4659–4665. [CrossRef]

20. Di Blasi, C.; Branca, C.; Galgano, A. Biomass Screening for the Production of Furfural via Thermal Decomposition. Ind. Eng. Chem. Res. 2010, 49, 2658–2671. [CrossRef]

21. Wang, S.; Lin, H.; Zhang, L.; Dai, G.; Zhao, Y.; Wang, X.; Ru, B. Structural Characterization and Pyrolysis Behavior of Cellulose and Hemicellulose Isolated from Softwood Pinus armandii Franch. Energy Fuels 2016, 30, 5721–5728. [CrossRef]

22. Rabemanolontsoa, H.; Saka, S. Comparative Study on Chemical Composition of Various Biomass Species. RSC Adv. 2013, 3, 3946. [CrossRef]

23. Demirbas¸, A. Thermochemical Conversion of Biomass to Liquid Products in the Aqueous Medium. Energy Sources 2005, 27, 1235–1243. [CrossRef]

24. Saini, J.K.; Saini, R.; Tewari, L. Lignocellulosic Agriculture Wastes as Biomass Feedstocks for Second-Generation Bioethanol Production: Concepts and Recent Developments. 3 Biotech 2015, 5, 337–353. [CrossRef]

25. Iqbal, H.M.N.; Kyazze, G.; Keshavarz, T. Advances in the Valorization of Lignocellulosic Materials by Biotechnology: An Overview. Bioresources 2013, 8, 3157–3176. [CrossRef]

26. Cerino-Córdova, F.J.; Dávila-Guzmán, N.E.; García León, A.M.; Salazar-Rabago, J.J.; Soto-Regalado, E. Revalorization of Coffee Waste. In Coffee-Production and Research; IntechOpen: London, UK, 2020.

27. Kai, D.; Chow, L.P.; Loh, X.J. Lignin and Its Properties. In Functional Materials from Lignin: Methods and Advances; World Scientific Publishing: Singapore, 2018; pp. 1–28.

28. Zhang, C.; Wang, F. Catalytic Lignin Depolymerization to Aromatic Chemicals. Acc. Chem. Res. 2020, 53, 470–484. [CrossRef] [PubMed]

29. Pollegioni, L.; Tonin, F.; Rosini, E. Lignin-Degrading Enzymes. FEBS J. 2015, 282, 1190–1213. [CrossRef] [PubMed]

30. Zhang, H.; Stephanopoulos, G. Co-culture Engineering for Microbial Biosynthesis of 3-amino-benzoic Acid in Escherichia coli. Biotechnol. J. 2016, 11, 981–987. [CrossRef] [PubMed]

31. Tolbert, A.; Akinosho, H.; Khunsupat, R.; Naskar, A.K.; Ragauskas, A.J. Characterization and Analysis of the Molecular Weight of Lignin for Biorefining Studies. Biofuels Bioprod. Biorefining 2014, 8, 836–856. [CrossRef]

32. Lin, S.Y.; Dence, C.W. (Eds.) Methods in Lignin Chemistry; Springer: Berlin/Heidelberg, Germany, 1992; ISBN 978-3-642-74067-1.

33. Jönsson, L.J.; Martín, C. Pretreatment of Lignocellulose: Formation of Inhibitory by-Products and Strategies for Minimizing Their Effects. Bioresour. Technol. 2016, 199, 103–112. [CrossRef] [PubMed]

34. Parthasarathi, R.; Romero, R.A.; Redondo, A.; Gnanakaran, S. Theoretical Study of the Remarkably Diverse Linkages in Lignin. J. Phys. Chem. Lett. 2011, 2, 2660–2666. [CrossRef]

35. Huang, J.; Wu, S.; Cheng, H.; Lei, M.; Liang, J.; Tong, H. Theoretical Study of Bond Dissociation Energies for Lignin Model Compounds. J. Fuel Chem. Technol. 2015, 43, 429–436. [CrossRef]

36. Weng, C.; Peng, X.; Han, Y. Depolymerization and Conversion of Lignin to Value-Added Bioproducts by Microbial and Enzymatic Catalysis. Biotechnol. Biofuels 2021, 14, 84. [CrossRef]

37. Kosa, M.; Ragauskas, A.J. Bioconversion of Lignin Model Compounds with Oleaginous Rhodococci. Appl. Microbiol. Biotechnol. 2012, 93, 891–900. [CrossRef]

38. Sainsbury, P.D.; Hardiman, E.M.; Ahmad, M.; Otani, H.; Seghezzi, N.; Eltis, L.D.; Bugg, T.D.H. Breaking Down Lignin to High-Value Chemicals: The Conversion of Lignocellulose to Vanillin in a Gene Deletion Mutant of Rhodococcus Jostii RHA1. ACS Chem. Biol. 2013, 8, 2151–2156. [CrossRef] [PubMed]

39. Becker, J.; Kuhl, M.; Kohlstedt, M.; Starck, S.; Wittmann, C. Metabolic Engineering of Corynebacterium glutamicum for the Production of Cis, Cis-Muconic Acid from Lignin. Microb. Cell Fact. 2018, 17, 115. [CrossRef] [PubMed]

40. Yu, J.; Stahl, H. Microbial Utilization and Biopolyester Synthesis of Bagasse Hydrolysates. Bioresour. Technol. 2008, 99, 8042–8048. [CrossRef]

41. Wu, W.; Dutta, T.; Varman, A.M.; Eudes, A.; Manalansan, B.; Loqué, D.; Singh, S. Lignin Valorization: Two Hybrid Biochemical Routes for the Conversion of Polymeric Lignin into Value-Added Chemicals. Sci. Rep. 2017, 7, 8420. [CrossRef] [PubMed]

42. Reshmy, R.; Athiyaman Balakumaran, P.; Divakar, K.; Philip, E.; Madhavan, A.; Pugazhendhi, A.; Sirohi, R.; Binod, P.; Kumar Awasthi, M.; Sindhu, R. Microbial Valorization of Lignin: Prospects and Challenges. Bioresour. Technol. 2022, 344, 126240. [CrossRef]

43. Bharathiraja, B.; Sridharan, S.; Sowmya, V.; Yuvaraj, D.; Praveenkumar, R. Microbial Oil–A Plausible Alternate Resource for Food and Fuel Application. Bioresour. Technol. 2017, 233, 423–432. [CrossRef]

44. Li-Beisson, Y.; Peltier, G. Third-Generation Biofuels: Current and Future Research on Microalgal Lipid Biotechnology. OCL 2013, 20, D606. [CrossRef]

45. Anthony, W.E.; Carr, R.R.; DeLorenzo, D.M.; Campbell, T.P.; Shang, Z.; Foston, M.; Moon, T.S.; Dantas, G. Development of Rhodococcus Opacus as a Chassis for Lignin Valorization and Bioproduction of High-Value Compounds. Biotechnol. Biofuels 2019, 12, 192. [CrossRef]

46. Shields-Menard, S.A.; AmirSadeghi, M.; Green, M.; Womack, E.; Sparks, D.L.; Blake, J.; Edelmann, M.; Ding, X.; Sukhbaatar, B.; Hernandez, R.; et al. The Effects of Model Aromatic Lignin Compounds on Growth and Lipid Accumulation of Rhodococcus Rhodochrous. Int. Biodeterior. Biodegrad. 2017, 121, 79–90. [CrossRef]

47. Botstein, D.; Chervitz, S.A.; Cherry, M. Yeast as a Model Organism. Science 1997, 277, 1259–1260. [CrossRef] [PubMed]

48. Huccetogullari, D.; Luo, Z.W.; Lee, S.Y. Metabolic Engineering of Microorganisms for Production of Aromatic Compounds. Microb. Cell Fact. 2019, 18, 41. [CrossRef] [PubMed]

49. Wang, J.; Gao, Q.; Zhang, H.; Bao, J. Inhibitor Degradation and Lipid Accumulation Potentials of Oleaginous Yeast Trichosporon cutaneum Using Lignocellulose Feedstock. Bioresour. Technol. 2016, 218, 892–901. [CrossRef] [PubMed]

50. Šantek, M.I.; Lisicˇar, J.; Mušak, L.; Špoljaric´, I.V.; Beluhan, S.; Šantek, B. Lipid Production by Yeast Trichosporon oleaginosus on the Enzymatic Hydrolysate of Alkaline Pretreated Corn Cobs for Biodiesel Production. Energy Fuels 2018, 32, 12501–12513. [CrossRef]

51. Zhu, L.Y.; Zong, M.H.; Wu, H. Efficient Lipid Production with Trichosporon fermentans and Its Use for Biodiesel Preparation. Bioresour. Technol. 2008, 99, 7881–7885. [CrossRef]

52. Chen, X.; Li, Z.; Zhang, X.; Hu, F.; Ryu, D.D.Y.; Bao, J. Screening of Oleaginous Yeast Strains Tolerant to Lignocellulose Degradation Compounds. Appl. Biochem. Biotechnol. 2009, 159, 591–604. [CrossRef]

53. Hu, M.; Wang, J.; Gao, Q.; Bao, J. Converting Lignin Derived Phenolic Aldehydes into Microbial Lipid by Trichosporon cutaneum. J. Biotechnol. 2018, 281, 81–86. [CrossRef]

54. Zhang, Y.; Bao, J. Tolerance of Trichosporon Cutaneum to Lignin Derived Phenolic Aldehydes Facilitate the Cell Growth and Cellulosic Lipid Accumulation. J. Biotechnol. 2022, 343, 32–37. [CrossRef]

55. Yaguchi, A.; Robinson, A.; Mihealsick, E.; Blenner, M. Metabolism of Aromatics by Trichosporon oleaginosus While Remaining Oleaginous. Microb. Cell Fact. 2017, 16, 206. [CrossRef]

56. Yaegashi, J.; Kirby, J.; Ito, M.; Sun, J.; Dutta, T.; Mirsiaghi, M.; Sundstrom, E.R.; Rodriguez, A.; Baidoo, E.; Tanjore, D.; et al. Rhodosporidium toruloides: A New Platform Organism for Conversion of Lignocellulose into Terpene Biofuels and Bioproducts. Biotechnol. Biofuels 2017, 10, 241. [CrossRef]

57. Juanssilfero, A.B.; Kahar, P.; Amza, R.L.; Miyamoto, N.; Otsuka, H.; Matsumoto, H.; Kihira, C.; Thontowi, A.; Yopi; Ogino, C.; et al. Selection of Oleaginous Yeasts Capable of High Lipid Accumulation during Challenges from Inhibitory Chemical Compounds. Biochem. Eng. J. 2018, 137, 182–191. [CrossRef]

58. Sànchez i Nogué, V.; Black, B.A.; Kruger, J.S.; Singer, C.A.; Ramirez, K.J.; Reed, M.L.; Cleveland, N.S.; Singer, E.R.; Yi, X.; Yeap, R.Y.; et al. Integrated Diesel Production from Lignocellulosic Sugars via Oleaginous Yeast. Green Chem. 2018, 20, 4349–4365. [CrossRef]

59. Singhania, R.R.; Patel, A.K.; Raj, T.; Chen, C.-W.; Ponnusamy, V.K.; Tahir, N.; Kim, S.-H.; Dong, C.-D. Lignin Valorisation via Enzymes: A Sustainable Approach. Fuel 2022, 311, 122608. [CrossRef]

60. Tien, M.; Kirk, T.K. Lignin-Degrading Enzyme from the Hymenomycete Phanerochaete chrysosporium Burds. Science 1983, 221, 661–663. [CrossRef]

61. Thurston, C.F. The Structure and Function of Fungal Laccases. Microbiology 1994, 140, 19–26. [CrossRef]

62. Claus, H. Laccases and Their Occurrence in Prokaryotes. Arch. Microbiol. 2003, 179, 145–150. [CrossRef] [PubMed]

63. Janusz, G.; Pawlik, A.; Sulej, J.; S´widerska-Burek, U.; Jarosz-Wilkołazka, A.; Paszczyn´ski, A. Lignin Degradation: Microorganisms, Enzymes Involved, Genomes Analysis and Evolution. FEMS Microbiol. Rev. 2017, 41, 941–962. [CrossRef]

64. Dikshit, P.K.; Jun, H.-B.; Kim, B.S. Biological Conversion of Lignin and Its Derivatives to Fuels and Chemicals. Korean J. Chem. Eng. 2020, 37, 387–401. [CrossRef]

65. Antošová, Z.; Sychrová, H. Yeast Hosts for the Production of Recombinant Laccases: A Review. Mol. Biotechnol. 2016, 58, 93–116. [CrossRef]

66. Rodgers, C.J.; Blanford, C.F.; Giddens, S.R.; Skamnioti, P.; Armstrong, F.A.; Gurr, S.J. Designer Laccases: A Vogue for High- Potential Fungal Enzymes? Trends Biotechnol. 2010, 28, 63–72. [CrossRef]

67. Vieira Gomes, A.; Souza Carmo, T.; Silva Carvalho, L.; Mendonça Bahia, F.; Parachin, N. Comparison of Yeasts as Hosts for Recombinant Protein Production. Microorganisms 2018, 6, 38. [CrossRef] [PubMed]

68. Karbalaei, M.; Rezaee, S.A.; Farsiani, H. Pichia Pastoris: A Highly Successful Expression System for Optimal Synthesis of Heterologous Proteins. J. Cell Physiol. 2020, 235, 5867–5881. [CrossRef] [PubMed]

69. Plácido, J.; Capareda, S. Ligninolytic Enzymes: A Biotechnological Alternative for Bioethanol Production. Bioresour. Bioprocess. 2015, 2, 23. [CrossRef]

70. Bourbonnais, R.; Paice, M.G. Oxidation of Non-Phenolic Substrates. FEBS Lett. 1990, 267, 99–102. [CrossRef]

71. Lee, K.-M.; Kalyani, D.; Tiwari, M.K.; Kim, T.-S.; Dhiman, S.S.; Lee, J.-K.; Kim, I.-W. Enhanced Enzymatic Hydrolysis of Rice Straw by Removal of Phenolic Compounds Using a Novel Laccase from Yeast Yarrowia Lipolytica. Bioresour. Technol. 2012, 123, 636–645. [CrossRef]

72. Kalyani, D.; Tiwari, M.K.; Li, J.; Kim, S.C.; Kalia, V.C.; Kang, Y.C.; Lee, J.-K. A Highly Efficient Recombinant Laccase from the Yeast Yarrowia lipolytica and Its Application in the Hydrolysis of Biomass. PLoS ONE 2015, 10, e0120156. [CrossRef]

73. Zhang, Q.; Zhao, L.; Li, Y.; Wang, F.; Li, S.; Shi, G.; Ding, Z. Comparative Transcriptomics and Transcriptional Regulation Analysis of Enhanced Laccase Production Induced by Co-Culture of Pleurotus eryngii Var. Ferulae with Rhodotorula mucilaginosa. Appl. Microbiol. Biotechnol. 2020, 104, 241–255. [CrossRef]

74. Wakil, S.; Adebayo-Tayo, B.; Odeniyi, O.; Salawu, K.; Eyiolawi, S.; Onilude, A. Production, Characterization and Purification of Laccase by Yeasts Isolated from Ligninolytic Soil. J. Pure Appl. Microbiol. 2017, 11, 847–869. [CrossRef]

75. Piscitelli, A.; Giardina, P.; Mazzoni, C.; Sannia, G. Recombinant Expression of Pleurotus ostreatus Laccases in Kluyveromyces lactis and Saccharomyces cerevisiae. Appl. Microbiol. Biotechnol. 2005, 69, 428–439. [CrossRef]

76. Yang, J.; Li, W.; Ng, T.B.; Deng, X.; Lin, J.; Ye, X. Laccases: Production, Expression Regulation, and Applications in Pharmaceutical Biodegradation. Front. Microbiol. 2017, 8, 832. [CrossRef]

77. Arana-Cuenca, A.; Téllez-Jurado, A.; Yagüe, S.; Fermiñan, E.; Carbajo, J.M.; Domínguez, A.; Gónzalez, T.; Villar, J.C.; González, A.E. Delignification of Pinus Radiata Kraft Pulp by Treatment with a Yeast Genetically Modified to Produce Laccases. For. Syst. 2010, 19, 234. [CrossRef]

78. Lu, C.; Wang, H.; Luo, Y.; Guo, L. An Efficient System for Pre-Delignification of Gramineous Biofuel Feedstock in Vitro: Application of a Laccase from Pycnoporus sanguineus H275. Process Biochem. 2010, 45, 1141–1147. [CrossRef]

79. Bao, W.; Peng, R.; Zhang, Z.; Tian, Y.; Zhao, W.; Xue, Y.; Gao, J.; Yao, Q. Expression, Characterization and 2,4,6-Trichlorophenol Degradation of Laccase from Monilinia fructigena. Mol. Biol. Rep. 2012, 39, 3871–3877. [CrossRef] [PubMed]

80. Liu, H.; Cheng, Y.; Du, B.; Tong, C.; Liang, S.; Han, S.; Zheng, S.; Lin, Y. Overexpression of a Novel Thermostable and Chloride- Tolerant Laccase from Thermus thermophilus SG0.5JP17-16 in Pichia pastoris and Its Application in Synthetic Dye Decolorization. PLoS ONE 2015, 10, e0119833. [CrossRef]

81. Popovic´, N.; Pržulj, D.; Mladenovic´, M.; Prodanovic´, O.; Ece, S.; Ilic´ Ðurd¯ic´, K.; Ostafe, R.; Fischer, R.; Prodanovic´, R. Immobi- lization of Yeast Cell Walls with Surface Displayed Laccase from Streptomyces cyaneus within Dopamine-Alginate Beads for Dye Decolorization. Int. J. Biol. Macromol. 2021, 181, 1072–1080. [CrossRef]

82. Ji, L.; Shen, Y.; Xu, L.; Peng, B.; Xiao, Y.; Bao, X. Enhanced Resistance of Saccharomyces cerevisiae to Vanillin by Expression of LacA from Trametes Sp. AH28-2. Bioresour. Technol. 2011, 102, 8105–8109. [CrossRef]

83. Larsson, S.; Cassland, P.; Jönsson, L.J. Development of a Saccharomyces cerevisiae Strain with Enhanced Resistance to Phenolic Fermentation Inhibitors in Lignocellulose Hydrolysates by Heterologous Expression of Laccase. Appl. Environ. Microbiol. 2001, 67, 1163–1170. [CrossRef]

84. Nishibori, N.; Masaki, K.; Tsuchioka, H.; Fujii, T.; Iefuji, H. Comparison of Laccase Production Levels in Pichia pastoris and Cryptococcus Sp. S-2. J. Biosci. Bioeng. 2013, 115, 394–399. [CrossRef]

85. Li, C.; Zhao, X.; Wang, A.; Huber, G.W.; Zhang, T. Catalytic Transformation of Lignin for the Production of Chemicals and Fuels. Chem. Rev. 2015, 115, 11559–11624. [CrossRef]

86. Higuchi, T. Microbial Degradation of Lignin: Role of Lignin Peroxidase, Manganese Peroxidase, and Laccase. Proc. Jpn. Acad. Ser. B 2004, 80, 204–214. [CrossRef]

87. Kumar, A.; Chandra, R. Ligninolytic Enzymes and Its Mechanisms for Degradation of Lignocellulosic Waste in Environment. Heliyon 2020, 6, e03170. [CrossRef]

88. Biko, O.D.V.; Viljoen-Bloom, M.; van Zyl, W.H. Microbial Lignin Peroxidases: Applications, Production Challenges and Future Perspectives. Enzym. Microb. Technol. 2020, 141, 109669. [CrossRef] [PubMed]

89. Ali, S.S.; Al-Tohamy, R.; Sun, J. Performance of Meyerozyma caribbica as a Novel Manganese Peroxidase-Producing Yeast Inhabiting Wood-Feeding Termite Gut Symbionts for Azo Dye Decolorization and Detoxification. Sci. Total Environ. 2022, 806, 150665. [CrossRef] [PubMed]

90. Samir Ali, S.; Al-Tohamy, R.; Khalil, M.A.; Ho, S.-H.; Fu, Y.; Sun, J. Exploring the Potential of a Newly Constructed Manganese Peroxidase-Producing Yeast Consortium for Tolerating Lignin Degradation Inhibitors While Simultaneously Decolorizing and Detoxifying Textile Azo Dye Wastewater. Bioresour. Technol. 2022, 351, 126861. [CrossRef]

91. González, M.; Brito, N.; Hernández-Bolaños, E.; González, C. New Tools for High-throughput Expression of Fungal Secretory Proteins in Saccharomyces cerevisiae and Pichia pastoris. Microb. Biotechnol. 2019, 12, 1139–1153. [CrossRef]

92. Wang, W.; Wen, X. Expression of Lignin Peroxidase H2 from Phanerochaete chrysosporium by Multi-Copy Recombinant Pichia Strain. J. Environ. Sci. 2009, 21, 218–222. [CrossRef]

93. Majeke, B.M.; García-Aparicio, M.; Biko, O.D.; Viljoen-Bloom, M.; van Zyl, W.H.; Görgens, J.F. Synergistic Codon Optimization and Bioreactor Cultivation toward Enhanced Secretion of Fungal Lignin Peroxidase in Pichia pastoris: Enzymatic Valorization of Technical (Industrial) Lignins. Enzym. Microb. Technol. 2020, 139, 109593. [CrossRef] [PubMed]

94. Wang, H.; Lu, F.; Sun, Y.; Du, L. Heterologous Expression of Lignin Peroxidase of Phanerochaete chrysosporium in Pichia methanolica. Biotechnol. Lett. 2004, 26, 1569–1573. [CrossRef] [PubMed]

95. Ryu, K.; Hwang, S.Y.; Kim, K.H.; Kang, J.H.; Lee, E.K. Functionality Improvement of Fungal Lignin Peroxidase by DNA Shuffling for 2,4-Dichlorophenol Degradability and H2O2 Stability. J. Biotechnol. 2008, 133, 110–115. [CrossRef]

96. Abdel-Hamid, A.M.; Solbiati, J.O.; Cann, I.K.O. Insights into Lignin Degradation and Its Potential Industrial Applications. In Advances in Applied Microbiology; Academic Press: Cambridge, MA, USA, 2013; pp. 1–28.

97. Gu, L.; Lajoie, C.; Kelly, C. Expression of a Phanerochaete Chrysosporium Manganese Peroxidase Gene in the Yeast Pichia pastoris. Biotechnol. Prog. 2003, 19, 1403–1409. [CrossRef] [PubMed]

98. Jiang, F.; Kongsaeree, P.; Schilke, K.; Lajoie, C.; Kelly, C. Effects of PH and Temperature on Recombinant Manganese Peroxidase Production and Stability. Appl. Biochem. Biotechnol. 2008, 146, 15–27. [CrossRef] [PubMed]

99. Jiang, F.; Kongsaeree, P.; Charron, R.; Lajoie, C.; Xu, H.; Scott, G.; Kelly, C. Production and Separation of Manganese Peroxidase from Heme Amended Yeast Cultures. Biotechnol. Bioeng. 2008, 99, 540–549. [CrossRef] [PubMed]

100. Xu, H.; Scott, G.M.; Jiang, F.; Kelly, C. Recombinant Manganese Peroxidase (RMnP) from Pichia pastoris. Part 1: Kraft Pulp Delignification. Holzforschung 2010, 64, 145–151. [CrossRef]

101. Xu, H.; Guo, M.-Y.; Gao, Y.-H.; Bai, X.-H.; Zhou, X.-W. Expression and Characteristics of Manganese Peroxidase from Ganoderma Lucidum in Pichia pastoris and Its Application in the Degradation of Four Dyes and Phenol. BMC Biotechnol. 2017, 17, 19. [CrossRef] [PubMed]

102. Yee, K.L.; Jansen, L.E.; Lajoie, C.A.; Penner, M.H.; Morse, L.; Kelly, C.J. Furfural and 5-Hydroxymethyl-Furfural Degradation Using Recombinant Manganese Peroxidase. Enzym. Microb. Technol. 2018, 108, 59–65. [CrossRef] [PubMed]

103. Zhang, H.; Zhang, X.; Geng, A. Expression of a Novel Manganese Peroxidase from Cerrena unicolor BBP6 in Pichia pastoris and Its Application in Dye Decolorization and PAH Degradation. Biochem. Eng. J. 2020, 153, 107402. [CrossRef]

104. Garcia-Ruiz, E.; Gonzalez-Perez, D.; Ruiz-Dueñas, F.J.; Martínez, A.T.; Alcalde, M. Directed Evolution of a Temperature-, Peroxide- and Alkaline PH-Tolerant Versatile Peroxidase. Biochem. J. 2012, 441, 487–498. [CrossRef] [PubMed]

105. Colao, M.; Lupino, S.; Garzillo, A.; Buonocore, V.; Ruzzi, M. Heterologous Expression of Lcc1 Gene from Trametes trogii in Pichia Pastoris and Characterization of the Recombinant Enzyme. Microb. Cell Fact. 2006, 5, 31. [CrossRef] [PubMed]

106. Ranieri, D.; Colao, M.C.; Ruzzi, M.; Romagnoli, G.; Bianchi, M.M. Optimization of Recombinant Fungal Laccase Production with Strains of the Yeast Kluyveromyces Lactis from the Pyruvate Decarboxylase Promoter. FEMS Yeast Res. 2009, 9, 892–902. [CrossRef]

107. Guo, M.; Lu, F.; Liu, M.; Li, T.; Pu, J.; Wang, N.; Liang, P.; Zhang, C. Purification of Recombinant Laccase from Trametes versicolor in Pichia methanolica and Its Use for the Decolorization of Anthraquinone Dye. Biotechnol. Lett. 2008, 30, 2091–2096. [CrossRef] [PubMed]

108. Zheng, M.; Chi, Y.; Yi, H.; Shao, S. Decolorization of Alizarin Red and Other Synthetic Dyes by a Recombinant Laccase from Pichia pastoris. Biotechnol. Lett. 2014, 36, 39–45. [CrossRef]

109. Lu, L.; Zhao, M.; Liang, S.-C.; Zhao, L.-Y.; Li, D.-B.; Zhang, B.-B. Production and Synthetic Dyes Decolourization Capacity of a Recombinant Laccase from Pichia pastoris. J. Appl. Microbiol. 2009, 107, 1149–1156. [CrossRef] [PubMed]

110. Gu, C.; Zheng, F.; Long, L.; Wang, J.; Ding, S. Engineering the Expression and Characterization of Two Novel Laccase Isoenzymes from Coprinus comatus in Pichia pastoris by Fusing an Additional Ten Amino Acids Tag at N-Terminus. PLoS ONE 2014, 9, e93912. [CrossRef]

111. Lin, Y.; Zhang, Z.; Tian, Y.; Zhao, W.; Zhu, B.; Xu, Z.; Peng, R.; Yao, Q. Purification and Characterization of a Novel Laccase from Coprinus Cinereus and Decolorization of Different Chemically Dyes. Mol. Biol. Rep. 2013, 40, 1487–1494. [CrossRef] [PubMed]

112. Li, J.F.; Hong, Y.Z.; Xiao, Y.Z.; Xu, Y.H.; Fang, W. High Production of Laccase B from Trametes Sp. in Pichia pastoris. World J. Microbiol. Biotechnol. 2007, 23, 741–745. [CrossRef]

113. Li, J.; Hong, Y.; Xiao, Y. Cloning and Heterologous Expression of the Gene of Laccase C from Trametes Sp. 420 and Potential of Recombinant Laccase in Dye Decolorization. Wei Sheng Wu Xue Bao 2007, 47, 54–58. [PubMed]

114. Hong, Y.; Zhou, H.; Tu, X.; Li, J.; Xiao, Y. Cloning of a Laccase Gene from a Novel Basidiomycete Trametes Sp. 420 and Its Heterologous Expression in Pichia pastoris. Curr. Microbiol. 2007, 54, 260–265. [CrossRef] [PubMed]

115. Li, Q.; Pei, J.; Zhao, L.; Xie, J.; Cao, F.; Wang, G. Overexpression and Characterization of Laccase from Trametes Versicolor in Pichia pastoris. Appl. Biochem. Microbiol. 2014, 50, 140–147. [CrossRef]

116. Li, Q.; Ge, L.; Cai, J.; Pei, J.; Xie, J.; Zhao, L. Comparison of Two Laccases from Trametes versicolor for Application in the Decolorization of Dyes. J. Microbiol. Biotechnol. 2014, 24, 545–555. [CrossRef] [PubMed]

117. Ilic´ Ðurd¯ic´, K.; Ece, S.; Ostafe, R.; Vogel, S.; Balaž, A.M.; Schillberg, S.; Fischer, R.; Prodanovic´, R. Flow Cytometry-Based System for Screening of Lignin Peroxidase Mutants with Higher Oxidative Stability. J. Biosci. Bioeng. 2020, 129, 664–671. [CrossRef] [PubMed]

118. Ilic´ Ðurd¯ic´, K.; Ece, S.; Ostafe, R.; Vogel, S.; Schillberg, S.; Fischer, R.; Prodanovic´, R. Improvement in Oxidative Stability of Versatile Peroxidase by Flow Cytometry-Based High-Throughput Screening System. Biochem. Eng. J. 2020, 157, 107555. [CrossRef]

119. Deparis, Q.; Claes, A.; Foulquié-Moreno, M.R.; Thevelein, J.M. Engineering Tolerance to Industrially Relevant Stress Factors in Yeast Cell Factories. FEMS Yeast Res. 2017, 17. [CrossRef] [PubMed]

120. Harwood, C.S.; Parales, R.E. The Beta-Ketoadipate Pathway and the Biology of Self-Identity. Annu Rev. Microbiol. 1996, 50, 553–590. [CrossRef] [PubMed]

121. Calixto-Campos, C.; Carvalho, T.T.; Hohmann, M.S.N.; Pinho-Ribeiro, F.A.; Fattori, V.; Manchope, M.F.; Zarpelon, A.C.; Baracat, M.M.; Georgetti, S.R.; Casagrande, R.; et al. Vanillic Acid Inhibits Inflammatory Pain by Inhibiting Neutrophil Recruitment, Oxidative Stress, Cytokine Production, and NFκB Activation in Mice. J. Nat. Prod. 2015, 78, 1799–1808. [CrossRef]

122. Kim, I.S.; Choi, D.-K.; Jung, H.J. Neuroprotective Effects of Vanillyl Alcohol in Gastrodia Elata Blume Through Suppression of Oxidative Stress and Anti-Apoptotic Activity in Toxin-Induced Dopaminergic MN9D Cells. Molecules 2011, 16, 5349–5361. [CrossRef]

123. Baruah, J.; Nath, B.K.; Sharma, R.; Kumar, S.; Deka, R.C.; Baruah, D.C.; Kalita, E. Recent Trends in the Pretreatment of Lignocellulosic Biomass for Value-Added Products. Front. Energy Res. 2018, 6, 141. [CrossRef]

124. Saratale, G.D.; Oh, M.-K. Improving Alkaline Pretreatment Method for Preparation of Whole Rice Waste Biomass Feedstock and Bioethanol Production. RSC Adv. 2015, 5, 97171–97179. [CrossRef]