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Benefits of pancreatic parenchymal endoscopic ultrasonography in predicting microscopic precancerous lesions of pancreatic cancer

Yamakawa, Kohei Inomata, Noriko Masuda, Atsuhiro Takenaka, Mamoru Toyama, Hirochika Sofue, Keitaro Sakai, Arata Kobayashi, Takashi Tanaka, Takeshi Tsujimae, Masahiro Ashina, Shigeto Gonda, Masanori Abe, Shohei Masuda, Shigeto Uemura, Hisahiro Kohashi, Shinya Nagao, Kae Harada, Yoshiyuki Miki, Mika Irie, Yosuke Juri, Noriko Shiomi, Hideyuki Kanzawa, Maki Itoh, Tomoo Fukumoto, Takumi Kodama, Yuzo 神戸大学

2023.07.25

概要

Pancreatic cancer primarily arises from microscopic precancerous lesions, such as pancreatic intraepithelial neoplasia (PanIN) and acinar-to-ductal metaplasia (ADM). However, no established method exists for predicting pancreatic precancerous conditions. Endoscopic ultrasonography (EUS) can detect changes in pancreatic parenchymal histology, including fibrosis. This study aimed to elucidate the relationship between pancreatic parenchymal EUS findings and microscopic precancerous lesions. We retrospectively analyzed 114 patients with pancreatobiliary tumors resected between 2010 and 2020 and evaluated the association between pancreatic parenchymal EUS findings and the number of PanIN, ADM, and pancreatic duct gland (PDG). Of the 114 patients, 33 (29.0%), 55 (48.2%), and 26 (22.8%) had normal EUS findings, hyperechoic foci/stranding without lobularity, and hyperechoic foci/stranding with lobularity, respectively. Multivariate analyses revealed that abnormal EUS findings were significantly associated with the frequency of PanIN (hyperechoic foci/stranding without lobularity: OR [95% CI] = 2.7 [1.0–7.3], with lobularity: 6.5 [1.9–22.5], P_trend = 0.01) and ADM (hyperechoic foci/stranding without lobularity: 3.1 [1.1–8.2], with lobularity: 9.7 [2.6–36.3], P_trend = 0.003) but not with PDG (hyperechoic foci/stranding without lobularity: 2.2 [0.8–5.8], with lobularity: 3.2 [1.0–10.2], P_trend = 0.12). We observed a trend toward a significantly higher number of precancerous lesions in the following order: normal findings, hyperechoic foci/stranding without lobularity, and hyperechoic foci/stranding with lobularity. Pancreatic parenchymal EUS findings were associated with the increased frequency of PanIN and ADM. Lobularity may help predict the increased number of precancerous lesions.

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Acknowledgements

This work was supported by grants from JSPS KAKENHI (20J12977: K.Y.; 19K08444: A.M.; 19H03698: Y.K.).

Author contributions

A.M. designed and supervised the study. K.Y. wrote the manuscript. A.M. and N.I. reviewed all EUS findings

in the study. K.Y., N.I., A.M., M.T., H.T., A.S., T.K., T.T, M.T, S.A., M.G., S.A., S.M., H.U., S.K., K.N., Y.H., and

M.M. collected the data. K.Y., N.I., and A.M. analyzed and interpreted the data. M.K. and T.I. reviewed all slides

in the study and advised on pathological diagnosis as needed. All authors critically revised this manuscript for

crucial intellectual content and provided their final approval of the version to be published.

Competing interests The authors declare no competing interests.

Additional information

Supplementary Information The online version contains supplementary material available at https://​doi.​org/​

10.​1038/​s41598-​023-​38920-1.

Correspondence and requests for materials should be addressed to A.M.

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