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Acknowledgements

This work was supported by the JSPS (17H01550, 18K15421, 20H00530), and Japan Association of Obstetricians

and Gynecologists Ogyaa Donation Foundation (JODF). We thank Charles Allan, PhD, and Catherine Perfect,

MA (Cantab), from Edanz (https://​jp.​edanz.​com/​ac), for editing a draft of this manuscript.

Author contributions

R.K. and T.U. designed the research, analyzed the data, and wrote the manuscript. M.Y., T.T., S.T., and Y.F. performed the experiments. K.K. and D.K. wrote the manuscript.

Competing interests The authors declare no competing interests.

Additional information

Supplementary Information The online version contains supplementary material available at https://​doi.​org/​

10.​1038/​s41598-​022-​07893-y.

Correspondence and requests for materials should be addressed to T.U.

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