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Acquired Coagulation Factor V Inhibitor That Was Successfully Treated with Oral Corticosteroid Therapy.

YOKOTA Yoshihiro INATOMI Osamu 70530351 0000-0002-5837-6575 NAKAGAWA Minami KAKUDA Kazuki HIROE Kousuke SAKAI Shigeki OSAKI Rie 40737665 IWASA Masaki 0000-0003-4116-7184 KAWAHARA Masahiro 80617449 0000-0002-2721-7571 KITO Katsuyuki ANDOH Akira 90252395 0000-0001-8533-2669 BAMBA Hiromichi 滋賀医科大学

2021.08.15

概要

Acquired coagulation factor V (FV) inhibitors are rare disorders in which antibodies against FV develop under various conditions. We herein report the case of a 71-year-old woman with FV inhibitor during radiochemotherapy for pancreatic cancer. Multiple purpuras suddenly appeared on her bilateral upper limbs with prolonged coagulation data (APTT 97.3 seconds). The FV activity was less than 3% and the FV inhibitor was positive (1.7 B.U./mL). Oral prednisolone induced a rapid normalization of the coagulation data and FV activity and a rapid disappearance of FV inhibitor within 7 days. Early diagnosis and treatment may therefore be important in cases of FV inhibitor.

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The Internal Medicine is an Open Access journal distributed under the Creative

Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To

view the details of this license, please visit (https://creativecommons.org/licenses/

by-nc-nd/4.0/).

Ⓒ 2021 The Japanese Society of Internal Medicine

Intern Med 60: 2663-2666, 2021

2666

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