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大学・研究所にある論文を検索できる 「神戸大学の女子学生における性感染症一次スクリーニング法としてのセルフサンプリングの実行可能性および容認性。」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。
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神戸大学の女子学生における性感染症一次スクリーニング法としてのセルフサンプリングの実行可能性および容認性。

Bule, Yara Priscilla Pedro ブレ, ヤラ プリシラ ペドロ 神戸大学

2023.03.25

概要

According to the World Health Organisation's (WHO) 2021 Global Progress Report, more than 1 million
curable sexual transmitted infections (STIs) are acquired every day, with incidence rates of 374 million
STIs per year, of which, 128 million cases are of Chlamydia trachomatis, 82 million cases are of
Neisseria gonorrhoeae, 7 million cases are of Treponema pallidum (syphilis) and 156 million cases are of
Trichomonas vaginalis.[1] Additionally, 291 million women are Human Papillomavirus (HPV) DNA
carriers and 500 million test positive for genital herpes simples virus (HSV-2).[2, 3]
A study by Kawado et. al. reported that the number of newly diagnosed cases in 2015 were 244 for
chlamydia, 87 for genital herpes and 89 for gonorrhoea per 100,000 population.[4] Moreover, the
Japanese National Institute of Infectious Diseases reported over 2,500 confirmed cases of syphilis
infection by April 2022, confirming a significant rise of new cases compared to the previous years.[5] It
was also reported that cervical cancer (CC) has an incidence rate of 13,277 new diagnoses per year and
mortality rate of 4,088 deaths per year, in women 15 years and older.[6] Young adults and adolescents are
among the group of people most vulnerable to STI infections,[7] and as STI rates continue to increase in
various countries around the world and in Japan, it is imperative to reduce barriers to STI screening and
sexual education.[8]
Screening programs are important to help evaluate, diagnose, treat and provide education in underscreened and hard-to-reach populations. Furthermore, screening methods should be cost effective, easily
transportable, stored, and accessed. To combat STIs and other gynaecological morbidities such as, HPV,
N. gonorrhoeae, C. trachomatis, T. pallidum and T. vaginalis, WHO guidelines give strong to conditional
recommendation to self-collected samples as an additional approach to STI testing services giving
credence to the use of self-sampling as a primary screening method in multiple countries worldwide.
[9-11] Aside from having characteristics of a good screening method, it also allows for patient privacy
and comfort. The type of self-sampling collected tools can be very diverse. Amongst them, dry swabs
have been reported to be a safe self-sampling collection tool with accurate and reliable results, even when
dry stored at room temperature for several days. [12-15] Furthermore, self-collected samples coupled
with DNA testing, have been shown to have the same and at times, higher sensitivity and specificity the
conventional methods, with no significant differences between self-sampling tools.[16-18]
Some of the WHO’s priorities for tackling STIs globally, for the next decade, is to (1) scale up point-ofcare diagnostics and self-testing, (2) Integrate sexual and reproductive health and rights, (3) Address
social and structural determinants, (4) Maximise the use of differentiated and people-centred service
delivery options and (5) Strengthen community engagement, community-based service delivery and
community-led monitoring.[1] In this study, we aim to address the priorities, above mentioned, within the
context of the Kobe University community. ...

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