Discovery of Bis-sulfonamides as Novel Inhibitors of Mitochondrial NADH-Quinone Oxidoreductase (Complex I)

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TOC Graphic

KPYC01112 (1)

IC 50 = 0.87 μM

Screening hit

SAR studies

O S

O S

32: IC 50 = 0.017 μM

O S

O S

35: IC 50 = 0.014 μM

...