リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

大学・研究所にある論文を検索できる 「Biclonal Diffuse Large B-cell Lymphoma Commonly Characterized by Partial Trisomy 18q Involving MALT1 and BCL2」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

コピーが完了しました

URLをコピーしました

論文の公開元へ論文の公開元へ
書き出し

Biclonal Diffuse Large B-cell Lymphoma Commonly Characterized by Partial Trisomy 18q Involving MALT1 and BCL2

Yamamoto, Katsuya Kawamoto, Shinichiro Chijiki, Ruri Watanabe, Marika Matsumoto, Sakuya Kitao, Akihito Mizutani, Yu Kajimoto, Kazuyoshi Hayashi, Yoshitake Yakushijin, Kimikazu Minami, Hironobu 神戸大学

2023.01.15

概要

A 68-year-old man was admitted because of a left shoulder mass and swollen right testis. Pathological examinations indicated a diagnosis of diffuse large B-cell lymphoma (DLBCL) with the CD20+BCL6+MUM1+BCL2+CD10-MYC- phenotype in both lesions. G-banding of soft tissue showed 47,XY,+18, whereas testicular cells showed 47,X,+X,-Y,der (4) t (4;18) (p15;?),del (5) (q?),+13. Fluorescence in situ hybridization detected additional MALT1 and BCL2 signals in both lesions. Southern blot demonstrated different IGH rearrangements between the soft tissue and testis. The patient was diagnosed with biclonal DLBCL with different karyotypes but similar immunophenotypes. Partial trisomy 18q involving MALT1 and BCL2 may be commonly involved in the pathogenesis of this biclonal DLBCL.

この論文で使われている画像

参考文献

1. Gascoyne RD, Campo E, Jaffe ES, et al. Diffuse large B-cell lymphoma, NOS. In: WHO Classification of Tumors of Haematopoietic and Lymphoid Tissues. 4th ed. Swerdlow SH, Campo E, Harris

NL, et al., Eds. IARC, Lyon, 2017: 291-297.

2. Cigudosa JC, Parsa NZ, Louie DC, et al. Cytogenetic analysis of

363 consecutively ascertained diffuse large B-cell lymphomas.

Genes Chromosomes Cancer 25: 123-133, 1999.

3. Zhao X, Fan R, Lin G, Wang X. Chromosome abnormalities in

diffuse large B-cell lymphomas: analysis of 231 Chinese patients.

Hematol Oncol 31: 127-135, 2013.

4. Van Dyke DL. +18 or trisomy 18 in lymphoproliferative disorders.

Atlas Genet Cytogenet Oncol Haematol 7: 274-276, 2003.

5. Mitelman F, Johansson B, Mertens F, Eds. Mitelman database of

chromosome aberrations and gene fusions in cancer (2022) [Internet]. [cited 2022 Feb 8]. Available from: http://mitelmandatabase.is

b-cgc.org

6. Sanchez ML, Almeida J, Gonzalez D, et al. Incidence and clinicobiologic characteristics of leukemic B-cell chronic lymphoproliferative disorders with more than one B-cell clone. Blood 102:

2994-3002, 2003.

7. Sanchez ML, Almeida J, Lopez A, et al. Heterogeneity of neoplastic cells in B-cell chronic lymphoproliferative disorders: biclonality versus intraclonal evolution of a single tumor cell clone. Haematologica 91: 331-339, 2006.

8. Fend F, Quintanilla-Martinez L, Kumar S, et al. Composite low

grade B-cell lymphomas with two immunophenotypically distinct

cell populations are true biclonal lymphomas. Am J Pathol 154:

1857-1866, 1999.

9. Sklar J, Cleary ML, Thielemans K, Gralow J, Warnke R, Levy R.

Biclonal B-cell lymphoma. N Engl J Med 311: 20-27, 1984.

10. Finch CN, Nichols M, Shrimpton A, Liu D, Hutchison RE. Primary nodal marginal zone B-cell lymphoma arising from more

than one clonal neoplastic population. Arch Pathol Lab Med 124:

1816-1819, 2000.

11. Chang H, Cerny J. Molecular characterization of chronic lymphocytic leukemia with two distinct cell populations. Am J Clin Pathol 126: 23-28, 2006.

12. Delville JP, Heimann P, Housni HE, et al. Biclonal low grade Bcell lymphoma confirmed by both flow cytometry and karyotypic

analysis, in spite of a normal kappa/lambda Ig light chain ratio.

Am J Hematol 82: 473-480, 2007.

13. Ankathil R, Geetha N, Remani P, Gangadharan VP, Pillai GR,

Nair MK. Clinical implications of cytogenetic classification in

adult acute lymphoblastic leukaemia patients. J Cancer Res Clin

Oncol 122: 370-373, 1996.

14. Wada M, Okamura T, Okada M, et al. Frequent chromosome arm

13q deletion in aggressive non-Hodgkin’s lymphoma. Leukemia

291

Intern Med 62: 285-292, 2023

DOI: 10.2169/internalmedicine.9711-22

13: 792-798, 1999.

15. Wong KF, Chan JKC. Follicular lymphoma with trisomy 18 and

over-expression of BCL2 in the absence of t(14;18)(q32;q21). Cancer Genet Cytogenet 123: 52-54, 2000.

16. Viardot A, Martin-Subero JI, Siebert R, et al. Detection of secondary genetic aberrations in follicle center cell derived lymphomas:

assessment of the reliability of comparative genomic hybridization

and standard chromosome analysis. Leukemia 15: 177-183, 2001.

17. Dierlamm J, Pittaluga S, Wlodarska I, et al. Marginal zone B-cell

lymphomas of different sites share similar cytogenetic and morphologic features. Blood 87: 299-307, 1996.

18. Troussard X, Mauvieux L, Radford-Weiss I, et al. Genetic analysis

of splenic lymphoma with villous lymphocytes: a Groupe Français

d’Hématologie Cellulaire (GFHC) study. Br J Haematol 101: 712721, 1998.

19. Remstein ED, Law M, Mollejo M, Piris MA, Kurtin PJ, Dogan A.

The prevalence of IG translocations and 7q32 deletions in splenic

marginal zone lymphoma. Leukemia 22: 1268-1272, 2008.

20. Vinatzer U, Gollinger M, Müllauer M, Raderer M, Chott A,

Streubel B. Mucosa-associated lymphoid tissue lymphoma: novel

translocations including rearrangements of ODZ2, JMJD2C, and

CNN3. Clin Cancer Res 14: 6426-6431, 2008.

21. Sunohara M, Hara K, Osamura K, et al. Mucosa associated lymphoid tissue (MALT) lymphoma of the thymus with trisomy 18.

Intern Med 48: 2025-2032, 2009.

22. Ishikawa H, Iwamuro M, Okuda H, et al. Recurrence after radiotherapy for gastric mucosa-associated lymphoid tissue (MALT)

lymphoma with trisomy 18. Intern Med 54: 911-916, 2015.

23. Takimoto T, Maegawa S, Tatsumi H, et al. Extranodal marginal

zone lymphoma of the uterine cervix with concomitant copy number gains of the MALT1 and BCL2 genes: a case report. Oncol

Lett 13: 3641-3645, 2017.

24. Matsueda K, Omote S, Sakata M, Fujita I, Horii J, Toyokawa T.

The diagnosis of gastric mucosa-associated lymphoid tissue lymphoma by flow cytometry and fluorescence in situ hybridization of

biopsy specimens. Intern Med 57: 1081-1086, 2018.

25. Okamoto N, Hayashi E, Tsukino M. Pleural mucosa-associated

lymphoid tissue lymphoma with trisomy 18. Intern Med 58: 891892, 2019.

26. Nakamura S, Ye H, Bacon CM, et al. Clinical impact of genetic

aberrations in gastric MALT lymphoma: a comprehensive analysis

using interphase fluorescence in situ hybridisation. Gut 56: 13581363, 2007.

27. Sugimoto K, Imai H, Shimada A, et al. Diffuse large B-cell lymphoma of the uterus suspected of having transformed from a marginal zone B-cell lymphoma harboring trisomy 18: a case report

and review of the literature. Int J Clin Exp Pathol 6: 2979-2988,

2013.

28. Dierlamm J, Penas EMM, Bentink S, et al. Gain of chromosome

region 18q21 including the MALT1 gene is associated with the activated B-cell-like gene expression subtype and increased BCL2

gene dosage and protein expression in diffuse large B-cell lymphoma. Haematologica 93: 688-696, 2008.

29. van Dongen JJM, Hooijkaas H, Michiels JJ, et al. Richter’s syndrome with different immunoglobulin light chains and different

heavy chain gene rearrangements. Blood 64: 571-575, 1984.

The Internal Medicine is an Open Access journal distributed under the Creative

Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To

view the details of this license, please visit (https://creativecommons.org/licenses/

by-nc-nd/4.0/).

Ⓒ 2023 The Japanese Society of Internal Medicine

Intern Med 62: 285-292, 2023

292

...

参考文献をもっと見る

全国の大学の
卒論・修論・学位論文

一発検索!

この論文の関連論文を見る