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Lipoprotein Particle Profiles Compared With Standard Lipids in the Association With Subclinical Aortic Valve Calcification in Apparently Healthy Japanese Men.

VU Thien FUJIYOSHI Akira 10567077 0000-0002-5790-7119 HISAMATSU Takashi KADOTA Aya 60546068 0000-0001-7378-0544 ZAID Maryam SEGAWA Hiroyoshi 0000-0001-9631-9769 KONDO Keiko 20566567 TORII Sayuki 30773973 NAKAGAWA Yoshihisa 00378613 SUZUKI Tomoaki 80402709 0000-0001-5836-899X ASAI Tohru 60346012 MIURA Katsuyuki 90257452 0000-0002-2646-9582 UESHIMA Hirotsugu 70144483 0000-0002-7742-4253 滋賀医科大学

2021.06.25

概要

Background:
Risk factors for atherosclerotic disease including dyslipidemia have been shown to be associated with aortic valve calcification (AVC). Nuclear magnetic resonance (NMR)-measured lipoprotein particles, low-density and high-density lipoprotein particles (LDL-p, HDL-p) in particular, have emerged as novel markers of atherosclerotic disease; however, whether NMR-measured particles are associated with AVC remains to be determined. This study aimed to examine the association between NMR-based lipoprotein particle measurements and standard lipids with AVC. The primary variables of interest were LDL-p (nmol/L), HDL-p (μmol/L), LDL-cholesterol, and HDL-cholesterol (both in mg/dL).Methods and Results:A community-based random sample of Japanese men aged 40-79 years examined in 2006-2008, in Shiga, Japan was studied. Presence of AVC was defined as an Agatston score >0. Lipoprotein particles were measured using NMR spectroscopy. In the main analysis, multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) for the prevalence of AVC across the higher quartiles of lipids in reference to the lowest ones were obtained. Of 874 participants analyzed, 153 men had AVC. Multivariable-adjusted ORs of prevalent AVC for the highest vs. the lowest quartile were significantly elevated for LDL-p (OR, 2.20; 95% CI: 1.23-3.93) and LDL-cholesterol (OR, 2.16; 95% CI: 1.23-3.78). In contrast, neither HDL-p nor HDL-cholesterol was associated with AVC.
Conclusions:
The association of prevalent AVC with NMR-based LDL-p was comparable to that with LDL-cholesterol.

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Supplementary Files

Please find supplementary file(s);

http://dx.doi.org/10.1253/circj.CJ-20-1090

Circulation Journal Vol.85, July 2021

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