リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

大学・研究所にある論文を検索できる 「Origin of diverse phosphorylation patterns in the ERBB system」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

コピーが完了しました

URLをコピーしました

論文の公開元へ論文の公開元へ
書き出し

Origin of diverse phosphorylation patterns in the ERBB system

Okada, Takashi Miyagi, Hiraku Sako, Yasushi Hiroshima, Michio Mochizuki, Atsushi 京都大学 DOI:10.1016/j.bpj.2021.12.031

2022.02

概要

Intercellular signals induce various cellular responses, including growth, proliferation, and differentiation, via the dynamic processes of signal transduction pathways. For cell fate decisions, ligand-binding induces the phosphorylation of ERBB receptors, which in turn activate downstream molecules. The ERBB family includes four subtypes, which diverged through two gene duplications from a common ancestor. Differences in the expression patterns of the subtypes have been reported between different organs in the human body. However, how these different expression properties influence the diverse phosphorylation levels of ERBB proteins is not well understood. Here we study the origin of the phosphorylation responses by experimental and mathematical analyses. The experimental measurements clarified that the phosphorylation levels heavily depend on the ERBB expression profiles. We developed a mathematical model consisting of the four subtypes as monomers, homodimers, and heterodimers and estimated the rate constants governing the phosphorylation responses from the experimental data. To understand the origin of the diversity, we analyzed the effects of the expression levels and reaction rates of the ERBB subtypes on the diversity. The difference in phosphorylation rates between ERBB subtypes showed a much greater contribution to the diversity than did the dimerization rates. This result implies that divergent evolution in phosphorylation reactions rather than in dimerization reactions after whole genome duplications was essential for increasing the diversity of the phosphorylation responses.

この論文で使われている画像

参考文献

1. Lemmon, M. A., and J. Schlessinger. 2010. Cell signaling by receptor

tyrosine kinases. Cell. 141:1117–1134.

17. Shi, F., S. E. Telesco, ., M. A. Lemmon. 2010. ErbB3/HER3

intracellular domain is competent to bind ATP and catalyze

autophosphorylation. Proc. Natl. Acad. Sci. U S A. 107:7692–

7697.

2. Oda, K., Y. Matsuoka, ., H. Kitano. 2005. A comprehensive pathway

map of epidermal growth factor receptor signaling. Mol. Syst. Biol.

1:2005.0010.

18. Olayioye, M. A. 2000. New EMBO members’ review: the ErbB

signaling network: receptor heterodimerization in development and

cancer. EMBO J. 19:3159–3167.

3. Gschwind, A., O. M. Fischer, and A. Ullrich. 2004. The discovery of

receptor tyrosine kinases: targets for cancer therapy. Nat. Rev. Cancer.

4:361–370.

19. Van Lengerich, B., C. Agnew, ., N. Jura. 2017. EGF and NRG

induce phosphorylation of HER3/ERBB3 by EGFR using distinct

oligomeric mechanisms. Proc. Natl. Acad. Sci. U S A.

114:E2836–E2845.

20. Nagashima, T., H. Shimodaira, ., M. Hatakeyama. 2006. Quantitative

transcriptional control of ErbB receptor signaling undergoes graded to

biphasic response for cell differentiation. J. Biol. Chem. 282:4045–

4056.

4. Lemmon, M. A., J. Schlessinger, and K. M. Ferguson. 2014. The EGFR

family: not so prototypical receptor tyrosine kinases. Cold Spring

Harb. Perspect. Biol. 6:a020768.

5. Citri, A., and Y. Yarden. 2006. EGF-ERBB signalling: towards the systems level. Nat. Rev. Mol. Cell Biol. 7:505–516.

6. Red Brewer, M., S. H. Choi, ., G. Carpenter. 2009. The juxtamembrane region of the EGF receptor functions as an activation domain.

Mol. Cell. 34:641–651.

7. Yarden, Y., and M. X. Sliwkowski. 2001. Untangling the ErbB signalling network. Nat. Rev. Mol. Cell Biol. 2:127–137.

8. Scaltriti, M., and J. Baselga. 2006. The epidermal growth factor receptor

pathway: a model for targeted therapy. Clin. Cancer Res. 12:5268–5272.

9. Alroy, I., and Y. Yarden. 1997. The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial

ligand-receptor interactions. FEBS Lett. 410:83–86.

10. Liu, P., T. Sudhaharan, ., T. Wohland. 2007. Investigation of the

dimerization of proteins from the epidermal growth factor receptor

family by single wavelength fluorescence cross-correlation spectroscopy. Biophys. J. 93:684–698.

11. Samaras, P., T. Schmidt, ., M. Wilhelm. 2020. ProteomicsDB: a

multi-omics and multi-organism resource for life science research.

Nucleic Acids Res. 48:D1153–D1163.

12. Schmidt, T., P. Samaras, ., M. Wilhelm. 2018. ProteomicsDB.

Nucleic Acids Res. 46:D1271–D1281.

13. Wilhelm, M., J. Schlegl, ., B. Kuster. 2014. Mass-spectrometry-based

draft of the human proteome. Nature. 509:582–587.

480 Biophysical Journal 121, 470–480, February 1, 2022

21. Nagashima, T., H. Shimodaira, ., M. Hatakeyama. 2007. Quantitative

transcriptional control of ErbB receptor signaling undergoes graded to

biphasic response for cell differentiation. J. Biol. Chem. 282:4045–

4056.

22. Fabricant, R. N., J. E. De Larco, and G. J. Todaro. 1977. Nerve growth

factor receptors on human melanoma cells in culture. Proc. Natl. Acad.

Sci. U S A. 74:565–569.

23. Jeong, H., J. Kim, ., A. Kim. 2014. Neuregulin-1 induces cancer stem

cell characteristics in breast cancer cell lines. Oncol. Rep. 32:1218–

1224.

24. Shankaran, H., H. S. Wiley, and H. Resat. 2006. Modeling the effects of

HER/ErbB1-3 coexpression on receptor dimerization and biological

response. Biophys. J. 90:3993–4009.

25. Shankaran, H., Y. Zhang, ., H. Resat. 2008. Quantifying the effects of co-expressing EGFR and HER2 on HER activation and

trafficking. Biochem. Biophys. Res. Commun. 371:220–224.

26. Mac Gabhann, F., and A. S. Popel. 2007. Dimerization of VEGF receptors and implications for signal transduction: a computational study.

Biophys. Chem. 128:125–139.

27. Kholodenko, B. N., O. V. Demin, ., J. B. Hoek. 1999. Quantification

of short term signaling by the epidermal growth factor receptor. J. Biol.

Chem. 274:30169–30181.

...

参考文献をもっと見る