リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

大学・研究所にある論文を検索できる 「The role of inflammatory biomarkers in predicting primary acquired nasolacrimal duct obstruction and postoperative recurrence」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。
リケラボ

コピーが完了しました

URLをコピーしました

論文の公開元へ論文の公開元へ
書き出し

The role of inflammatory biomarkers in predicting primary acquired nasolacrimal duct obstruction and postoperative recurrence

Garip, Rüveyde Sakallıoğlu, Ahmet Kürşad 名古屋大学

2023.05

概要

Primary acquired nasolacrimal duct obstruction (PANDO) is a common ophthalmologic problem
of the lacrimal passages that causes epiphora.1 PANDO is characterized by idiopathic inflammation
and fibrosis, resulting in partial stenosis or complete occlusion of the nasolacrimal duct.2,3 Many
factors have been suggested that trigger the inflammation in PANDO, such as infection in the
conjunctiva, sinusitis, and nasal pathway diseases.1,3 Although the main etiological factors causing
PANDO remain unknown, it is recognized that chronic inflammation has a prominent role in its
pathogenesis.2-4 Dacryocystorhinostomy (DCR), which is based on the creation of an alternative
pathway for drainage of tears between the lacrimal sac and nasal cavity, is considered the gold
standard treatment for PANDO.5
Recently, white blood cells, neutrophil, monocyte, platelet, neutrophil-to-lymphocyte ratio
(NLR), and platelet-to-lymphocyte ratio (PLR) have been proposed as indicators of subclinical
systemic inflammation.6 These simple and inexpensive methods for assessing inflammation have
been used as predictors of several ocular diseases, including dry eye,7 retinal vein occlusion,8
neovascular glaucoma,6 diabetic retinopathy,9 and age-related macular degeneration.10
The systemic immune-inflammation index (SII) is a novel inflammatory biomarker that has
been proposed as a prognostic indicator in various diseases, such as cancer,11 stroke,12 cardiovascular diseases,13,14 and systemic inflammatory disorders.15 Tang et al16 suggested that NLR
and SII might serve as inflammatory predictors in primary open-angle glaucoma patients. Ozcan
et al17 reported that the SII is superior to other inflammatory biomarkers in dry eye patients.
Atum and Alagöz18 reported higher NLR and lower mean platelet volume levels in PANDO
patients compared to healthy controls and suggested that NLR and mean platelet volume counts
were associated with PANDO.
Based on this knowledge, it has been hypothesized that there might be a relationship between
subclinical systemic inflammation and the development of PANDO. Therefore, this study aims
to determine the relationship of inflammatory biomarkers, including NLR, PLR, and SII, with
PANDO and to evaluate whether they can be used as indicators in determining the risk of
recurrence after DCR. ...

論文の公開元へ

この論文で使われている画像

関連論文

関連論文をもっと見る

参考文献

1 Ohtomo K, Ueta T, Toyama T, Nagahara M. Predisposing factors for primary acquired nasolacrimal duct

obstruction. Graefes Arch Clin Exp Ophthalmol. 2013;251(7):1835–1839. doi:10.1007/s00417-013-2288-5.

2 Kashkouli MB, Sadeghipour A, Kaghazkanani R, Bayat A, Pakdel F, Aghai GH. Pathogenesis of primary

acquired nasolacrimal duct obstruction. Orbit. 2010;29(1):11–15. doi:10.3109/01676830903207828.

3 Makselis A, Petroska D, Kadziauskiene A, et al. Acquired nasolacrimal duct obstruction: clinical and

histological findings of 275 cases. BMC Ophthalmol. 2022;22(1):12. doi:10.1186/s12886-021-02185-x.

4 Gul A, Aslan K, Karli R, Ariturk N, Can E. A possible cause of nasolacrimal duct obstruction: narrow

angle between inferior turbinate and upper part of the medial wall of the maxillary sinus. Curr Eye Res.

2016;41(6):729–733. doi:10.3109/02713683.2015.1052520.

5 Ghasemi H, Asghari Asl S, Yarmohammadi ME, Jafari F, Izadi P. External dacryocystorhinostomy; success

rate and causes of failure in endoscopic and pathologic evaluations. Iran J Pathol. 2017;12(3):189–194.

6 Zhang A, Ning L, Han J, et al. Neutrophil-to-lymphocyte ratio as a potential biomarker of neovascular

glaucoma. Ocul Immunol Inflamm. 2021;29(2):417–424. doi:10.1080/09273948.2019.1677916.

7 Sekeryapan B, Uzun F, Buyuktarakci S, Bulut A, Oner V. Neutrophil-to-lymphocyte ratio increases in

Nagoya J. Med. Sci. 85. 289–298, 2023

296

doi:10.18999/nagjms.85.2.289

Nasolacrimal duct and inflammation

patients with dry eye. Cornea. 2016;35(7):983–986. doi:10.1097/ICO.0000000000000872.

8 Dursun A, Ozturk S, Yucel H, et al. Association of neutrophil/lymphocyte ratio and retinal vein occlusion.

Eur J Ophthalmol. 2015;25(4):343–346. doi:10.5301/ejo.5000570.

9 Ulu SM, Dogan M, Ahsen A, et al. Neutrophil-to-lymphocyte ratio as a quick and reliable predictive marker

to diagnose the severity of diabetic retinopathy. Diabetes Technol Ther. 2013;15(11):942–947. doi:10.1089/

dia.2013.0097.

10 Ilhan N, Daglioglu MC, Ilhan O, et al. Assessment of neutrophil/lymphocyte ratio in patients with age-related

macular degeneration. Ocul Immunol Inflamm. 2015;23(4):287–290. doi:10.3109/09273948.2014.921715.

11 Zhou Y, Dai M, Zhang Z. Prognostic significance of the systemic immune-inflammation index (SII)

in patients with small cell lung cancer: A meta-analysis. Front Oncol. 2022;12:814727. doi:10.3389/

fonc.2022.814727.

12 Chen PY, Chen GC, Hsiao CL, et al. Comparison of clinical features, immune-inflammatory markers,

and outcomes between patients with acute in-hospital and out-of-hospital ischemic stroke. J Inflamm Res.

2022;15:881–895. doi:10.2147/JIR.S342830.

13 Luo Y, Zhang J, Liu T, et al. The systemic-immune-inflammation index predicts the recurrence of atrial

fibrillation after cryomaze concomitant with mitral valve surgery. BMC Cardiovasc Disord. 2022;22(1):45.

doi:10.1186/s12872-022-02494-z.

14 Esenbog˘a K, Kurtul A, Yamantürk YY, Akbulut I˙M, Tutar DE. Comparison of systemic immune-inflammation

index levels in patients with isolated coronary artery ectasia versus patients with obstructive coronary artery

disease and normal coronary angiogram. Scand J Clin Lab Invest. 2022;82(2):132–137. doi:10.1080/00365

513.2022.2034034.

15 Pakoz ZB, Ustaoglu M, Vatansever S, Yuksel ES, Topal F. Serum immune-inflammation index assessment in

the patients with ulcerative colitis. Gastroenterol Res Pract. 2022;2022:9987214. doi:10.1155/2022/9987214.

16 Tang B, Li S, Han J, Cao W, Sun X. Associations between blood cell profiles and primary open-angle

glaucoma: a retrospective case-control study. Ophthalmic Res. 2020;63(4):413–422. doi:10.1159/000504450.

17 Ozarslan Ozcan D, Kurtul BE, Ozcan SC, Elbeyli A. Increased systemic immune-inflammation index levels

in patients with dry eye disease. Ocul Immunol Inflamm. 2022;30(3):588–592. doi:10.1080/09273948.2020.

1821899.

18 Atum M, Alagöz G. Blood cell ratios in patients with primary acquired nasolacrimal duct obstruction.

Ophthalmol J. 2020;5:76–80. doi:10.5603/OJ.2020.0017.

19 Elbeyli A, Kurtul BE, Ozcan DO, Ozcan SC, Dogan E. Assessment of red cell distribution width, platelet/

lymphocyte ratio, systemic immune-inflammation index, and neutrophil/lymphocyte ratio values in patients

with central retinal artery occlusion. Ocul Immunol Inflamm. 2022;30(7–8):1940–1944. doi:10.1080/092739

48.2021.1976219.

20 Zuo W, Chen T, Song J, Ai M. Assessment of systemic immune-inflammation index levels in patients with

retinal vein occlusion. Ocul Immunol Inflamm. 2022;1–5. doi:10.1080/09273948.2022.2032199.

21 Elbeyli A, Kurtul BE. Systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, and plateletto-lymphocyte ratio levels are associated with keratoconus. Indian J Ophthalmol. 2021;69(7):1725–1729.

doi:10.4103/ijo.IJO_3011_20.

22 DeAngelis D, Hurwitz J, Oestreicher J, Howarth D. The pathogenesis and treatment of lacrimal obstruction :

The value of lacrimal sac and bone analysis. Orbit. 2001;20(3):163–172. doi:10.1076/orbi.20.3.163.2626.

23 Linberg JV, McCormick SA. Primary acquired nasolacrimal duct obstruction. A clinicopathologic report and

biopsy technique. Ophthalmology. 1986;93(8):1055–1063. doi:10.1016/s0161-6420(86)33620-0.

24 Amin RM, Hussein FA, Idriss HF, Hanafy NF, Abdallah DM. Pathological, immunohistochemical and

microbiologicalal analysis of lacrimal sac biopsies in patients with chronic dacrocystitis. Int J Ophthalmol.

2013;6(6):817–826. doi:10.3980/j.issn.2222-3959.2013.06.14.

25 Ciftci F, Ers¸anli D, Civelek L, Baloglu H, Karadayi K, Güngör A. Histopathologic changes in the lacrimal

sac of dacryocystorhinostomy patients with and without silicone intubation. Ophthalmic Plast Reconstr Surg.

2005;21(1):59–64. doi:10.1097/01.iop.0000148408.51615.fe.

26 Fernández-Colino A, Iop L, Ventura Ferreira MS, Mela P. Fibrosis in tissue engineering and regenerative

medicine: treat or trigger? Adv Drug Deliv Rev. 2019;146:17–36. doi:10.1016/j.addr.2019.07.007.

27 Leong SC, Macewen CJ, White PS. A systematic review of outcomes after dacryocystorhinostomy in adults.

Am J Rhinol Allergy. 2010;24(1):81–90. doi:10.2500/ajra.2010.24.3393.

28 Onerci M, Orhan M, Ogretmenog˘lu O, Irkeç M. Long-term results and reasons for failure of intranasal endoscopic dacryocystorhinostomy. Acta Otolaryngol. 2000;120(2):319–322. doi:10.1080/000164800750001170.

29 Apaydin KC, Fisenk F, Karayalcin B, Akar Y, Saka O. Endoscopic transnasal dacryocystorhinostomy and

bicanalicular silicone tube intubation. Ophthalmologica. 2004;218(5):306–311. doi:10.1159/000079471.

Nagoya J. Med. Sci. 85. 289–298, 2023

297

doi:10.18999/nagjms.85.2.289

Rüveyde Garip and Ahmet Kürs¸ad Sakallıog˘lu

30 Qian Z, Zhang Y, Fan X. Clinical outcomes of dacryocystorhinostomy with or without intraoperative use

of mitomycin C: a systematic review and meta-analysis. J Ocul Pharmacol Ther. 2014;30(8):615–624.

doi:10.1089/jop.2013.0230.

31 Tsirbas A, Wormald PJ. Endonasal dacryocystorhinostomy with mucosal flaps. Am J Ophthalmol.

2003;135(1):76–83. doi:10.1016/s0002-9394(02)01830-5.

32 Ha TS, Na KS, Chi NC. Effectiveness of washing nasolacrimal duct as an additional therapy after

dacryocystorhinostomy. J Korean Ophthalmol Soc. 2000;41(11):2308–2312.

References End

Nagoya J. Med. Sci. 85. 289–298, 2023

298

doi:10.18999/nagjms.85.2.289

...

参考文献をもっと見る

全国の大学の
卒論・修論・学位論文
を
一発検索！

この論文の関連論文を見る