1. Gotoda T, Yamamoto H, Soetikno R. Endoscopic submucosal dissection of early
gastric cancer. J Gastroenterol 2006; 41: 929-942.
2. Oda I, Gotoda T, Hamanaka H, Eguchi T, Saito Y, Matsuda T, et al. Endoscopic
submucosal dissection for early gastric cancer: technical feasibility, operation time
and com- plications from a large consecutive series. Dig Endosc 2005; 17: 54-58.
3. Yamamoto H, Kawata H, Sunada K, Sasaki A, Nakazawa K, Miyata T, et al.
Successful one-piece resection of large superficial tumors in the stomach and colon
using sodium hyaluronate and small-caliber-tip transparent hood. Endoscopy 2003;
35: 690-694.
4. Oyama T, Kikuchi Y. Aggressive endoscopic mucosal resection in the upper GI tract
– Hook knife EMR method. Minim Invasive Ther Allied Technol 2002; 11: 291-295.
5. Naohisa Yahagi, Mitsuhiro Fujishiro, Naomi Kakushima, Katsuya Kobayashi,
Takuhei Hashimoto, Masashi Oka, et al. Endoscopic submucosal dis- section for early
gastric cancer using the tip ofan electrosurgical snare (thin type). Dig Endosc 2004;
16: 34-38.
6. Oda I, Saito D, Tada M, Iishi H, Tanabe S, Oyama T, et al. A multicenter retrospective
study of endoscopic resection for early gastric cancer. Gastric Cancer 2006; 9: 262270.
7. Takizawa K, Oda I, Gotoda T, Yokoi C, Matsuda T, Saito Y, et al. Routine
coagulation of visible vessels may prevent delayed bleeding after endoscopic
submucosal dissection – an analysis of risk factors. Endoscopy 2008; 40: 179-183.
8. Miyahara K, Iwakiri R, Shimoda R, Sakata Y, Fujise T, Shiraishi R, et al. Perforation
and postoperative bleeding of endoscopic submucosal dissection in gastric tumors:
analysis of 1190 lesions in low- and high-volume centers in Saga, Japan. Digestion
2012; 86: 273-280.
9. Gong EJ, Kim DH, Jung HY, Choi YK, Lim H, Choi KS, et al. Clinical outcomes of
endoscopic resection for gastric neoplasms in the pylorus. Surg Endosc 2015; 29:
3491-3498.
10. Kakushima N, Tanaka M, Sawai H, Imai K, Kawata N, Hagiwara T, et al. Gastric
obstruction after endoscopic submucosal dissection. United Eur Gastroenterol J
2013; 1: 184-190.
11. Iizuka H, Kakizaki S, Sohara N, Onozato Y, Ishihara H, Okamura S, et al. Stricture
after endoscopic submucosal dissection for early gastric cancers and adenomas. Dig
Endosc 2010; 22: 282-288.
12. Sumiyoshi T, Kondo H, Minagawa T, Fujii R, Sakata K, Inaba K, et al. Risk factors
and management for gastric stenosis after endoscopic submucosal dissection for
gastric epithelial neoplasm. Gastric Cancer 2017; 20: 690-698.
13. Coda S, Oda I, Gotoda T, Yokoi C, Kikuchi T, Ono H. Risk factors for cardiac and
pyloric stenosis after endoscopic submucosal dissection, and efficacy of endoscopic
balloon dilation treatment. Endoscopy 2009; 41:421-426.
14. Lee JU, Park MS, Yun SH, Yang MA, Han SH, Lee YJ, et al. Risk factors and
management for pyloric stenosis occurred after endoscopic submucosal dissection
adjacent to pylorus. Med (United States) 2016; 95: e5633.
15. Takayama H, Toyonaga T, Yoshizaki T, Abe H, Nakai T, Ueda C, et al. Timing of
pyloric stenosis and effectiveness of endoscopic balloon dilation after pyloric
endoscopic submucosal dissection. J Gastroenterol Hepatol 2021; 36(11):3158-3163.
16. Yoshizaki T, Obata D, Aoki Y, Okamoto N, Hashimura H, Kano C, et al. Endoscopic
submucosal dissection for early gastric cancer on the lesser curvature in upper third
of the stomach is a risk factor for postoperative delayed gastric emptying. Surg
Endosc 2018; 32(8): 3622-3629.
17. Ohara Y, Toyonaga T, Tanabe A, Takihara H, Baba S, Inoue T, et al. Endoscopic
antralplasty for severe gastric stasis after wide endoscopic submucosal dissection in
the antrum. Clin J Gastroenterol 2016; 9:63-67.
18. Uozumi T, Sakano H, Okagawa Y, Hirayama M, Sumiyoshi T, Tomita Y, et al.
Laparoscopic gastrojejunostomy to manage gastric outlet obstruction associated with
endoscopic submucosal dissection of large gastric epithelial neoplasms : A two-case
report. DEN open 2022; 2: e18.
19. Toyonaga T, Man-i M, East JE, Nishino E, Ono W, Hirooka T, et al. 1,635
Endoscopic submucosal dissection cases in the esophagus, stomach, and
colorectum: Complication rates and long-term outcomes. Surg Endosc 2013; 27:
1000–8.
20. Toyonaga T, Inokuchi H, Man-I M, Morita Y, Yoshida M, Kutsumi H, et al.
Endoscopic submucosal dissection using water jet short needle knives (Flush knife)
for the treatment of gastrointestinal epithelial neoplasms. Acta Endoscopica 2007;
37: 645–656.
21. Toyonaga T, Nishino E, Hirooka T, Dozaiku T, Suguyama T, Iwata Y, et al. Use of
short needle knife for esophageal endoscopic submucosal dissection. Dig Endosc
2005; 17: 246–252.
22. Toyonaga T, Nishino E, Hirooka T, Ueda C, Noda K. Intraoperative bleeding in
endoscopic submucosal dissection in the stomach and strategy for prevention and
treatment. Dig Endosc 2006; 18: S123–S127.
23. Toyonaga T, Man-i M, Fujita T, East JE, Nishino E, Ono W, et al. Retrospective
study of technical aspects and complications of endoscopic submucosal dissection
for laterally spreading tumors of the colorectum. Endoscopy 2010; 42: 714–722.
24. Japanese Gastric Cancer Association. Japanese gastric cancer treatment guidelines
2010 (ver 3). Gastric Cancer 2011; 14 (2): 113-123.
25. Japanese Gastric Cancer Association. Japanese gastric cancer treatment guidelines
2014 (ver 4). Gastric Cancer 2017; 20 (1): 1-19.
26. Japanese Gastric Cancer Association. Japanese gastric cancer treatment guidelines
2018 (5th edition). Gastric Cancer 2020; 24 (1): 1-21.
27. Kishida Y, Kakushima N, Kawata N, Tanaka M, Takizawa K, Imai K, et al. Adverse
events associated with endoscopic dilation for gastric stenosis after endoscopic
submucosal dissection for early gastric cancer. Surg Endosc 2015; 29: 3776-3782.
28. Tsunada S, Ogata S, Mannen K, Arima S, Sakata Y, Shiraishi R, et al. Case series of
endoscopic balloon dilation to treat a stricture caused by circumferential resection of
the gastric antrum by endoscopic submucosal dissection. Gastrointest Endosc 2008;
67:979-983.
Figure legends
Fig. 1. a) Stenosis was defined as a condition in which an endoscope could not pass
from the antrum to the duodenum. b) Deformation was defined as a condition in which
a large luminal curvature was shown by esophagogastroduodenoscopy, resulting in
gastric stasis, but the endoscope could pass from the antrum to the duodenum.
Fig. 2. a) We performed endoscopic submucosal dissection (ESD) in the lower part of
the stomach so that the circumferential mucosal defect was greater than 3/4. The
mucosal defect was beyond the angular region but not on the pyloric ring. b) During the
healing process of the artificial ulcer, the antrum was deformed and the pyloric ring
could not be seen. A large amount of food residue remained in the stomach. c) We
performed additional ESD on the greater curvature in the antrum, which was
contralateral to the post-ESD site. d) The deformation was gradually released by the
contralateral traction that occurred during improvement of the new artificial ulcer. We
could observe the gastric lumen in the antrum.
Fig. 3. The flow chart of patients and lesions included in this study.
Table 1. Characteristics of 41 cases
Age
74(68-80)
Gender
Male
28
Female
13
Pyloric dissection
26
Angular dissection
11
Location
Lesser curve
26
Greater curve
Anterior wall
Posterior wall
Circumferential extent of mucosal defect, %
86 (83-95)
macroscopic type
elevated
28
depressed
13
invasion depth
mucosal
36
submucosal
Ulcer findings
10
Specimen diameter (mm)
60
Use of steroids
11
Deformation
Stenosis
36
Perforation by EBD
Data represents the number of patients or median (interquartile range)
EBD: Endoscopic balloon dilation
Table 2. Comparison of deformation and non-deformation (stenosis) cases
Age, years
Deformation (+)
Deformation (-)
n=5
n=34
69 (68-75)
p-value
74 (68-83)
Gender
0.64
female
11
male
25
Pyloric dissection
0.004
present
26
absent
10
Angular dissection
<0.001
present
absent
30
Location
0.63
Lesser curve
21
Greater curve
Anterior wall
Posterior wall
84 (83-90)
86 (82-95)
Circumferential extent of
mucosal defect (%)
0.34
Macroscopic type
0.79
0.30
elevated
26
depressed
10
Invasion depth
mucosal
31
submucosal
Ulcer findings
0.58
present
absent
28
Specimen diameter (mm)
110 (102-113)
57 (45-68)
Use of steroid
0.003
present
10
absent
26
Data represents the number of patients or median (interquartile range)
Table 3. Deformation cases depending on dissection range
Dissection range
Deformation rate
Angular dissection (+), Pyloric dissection (-)
63% (5/8)
Angular dissection (+), Pyloric dissection (+)
0% (0/3)
Angular dissection (-), Pyloric dissection (-)
0% (0/7)
Angular dissection (-), Pyloric dissection (+)
0% (0/23)
Data represents rate (Number of deformation cases/ Number of all cases)
Table 4. Characteristics of five cases with deformation
Specimen
No
diameter
(mm)
Circumferential
extent of the
mucosal defect
(%)
Number of
EBDs
(number)
Maximum
Diameter
of EBDs
(mm)
Period
Period from
from ESD
ESD to
to gastric
additional
stasis
treatment (day)
Additional
treatment
(day)
128
83
18
25
91
Distal gastrectomy
63
84
20
27
71
Distal gastrectomy
113
95
20
48
78
Gastrojejunostomy
102
90
14
20
41
125
EAP
102
83
20
46
157
EAP
EBD: Endoscopic balloon dilation, ESD: endoscopic submucosal dissection, EAP:
Endoscopic antralplasty
...