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Characteristics of Gastric Stasis due to Deformation after Endoscopic Submucosal Dissection in the Lower Part of the Stomach

Takayama, Hiroshi Toyonaga, Takashi Yoshizaki, Tetsuya Abe, Hirofumi Nakai, Tatsuya Ueda, Chise Urakami, Satoshi Kaku, Hidetoshi Shimamoto, Yusaku Matsumoto, Kei Tsuda, Kazunori Sakaguchi, Hiroya Baba, Shinichi Takihara, Hiroshi Ikezawa, Nobuaki Tanaka, Shinwa Takao, Madoka Takao, Toshitatsu Morita, Yoshinori Kodama, Yuzo 神戸大学

2023.03.22

概要

Introduction: Gastric stasis due to deformation occurs after endoscopic submucosal dissection in the lower part of the stomach. Endoscopic balloon dilation can improve gastric stasis due to stenosis; however, endoscopic balloon dilation cannot improve gastric stasis due to deformation. Furthermore, the characteristics of gastric stasis due to deformation are unknown. This study aimed to evaluate the characteristics of gastric stasis due to deformation after endoscopic submucosal dissection in the lower part of the stomach, focusing on the differences between stenosis and deformation. Methods: We retrospectively reviewed 41 patients with gastric stasis after endoscopic submucosal dissection in the lower part of the stomach. We evaluated the characteristics of cases with gastric stasis due to deformation, such as the risk factors of deformation and the rate of deformation in each group with risk factors. Results: Deformation was observed in 12% (5/41) of the patients with gastric stasis. All cases of deformation had a circumferential extent of the mucosal defect greater than 3/4. The number of cases with pyloric dissection was significantly lower in the deformation group than in the non-deformation group (0% vs. 72%; p = 0.004). The deformation group also had a significantly higher number of cases with angular dissection than the non-deformation group (100% vs. 17%; p < 0.001). Moreover, the deformation cases had a significantly larger specimen diameter (p < 0.001). Deformation was observed only in cases with angular and non-pyloric dissections. Deformation was not observed in cases with angular and pyloric dissections. Conclusions: All cases of gastric stasis due to deformation had a circumferential extent of the mucosal defect greater than 3/4. Deformation was also likely to occur in cases with a larger dissection that exceeded the angular region without pyloric dissection.

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参考文献

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Figure legends

Fig. 1. a) Stenosis was defined as a condition in which an endoscope could not pass

from the antrum to the duodenum. b) Deformation was defined as a condition in which

a large luminal curvature was shown by esophagogastroduodenoscopy, resulting in

gastric stasis, but the endoscope could pass from the antrum to the duodenum.

Fig. 2. a) We performed endoscopic submucosal dissection (ESD) in the lower part of

the stomach so that the circumferential mucosal defect was greater than 3/4. The

mucosal defect was beyond the angular region but not on the pyloric ring. b) During the

healing process of the artificial ulcer, the antrum was deformed and the pyloric ring

could not be seen. A large amount of food residue remained in the stomach. c) We

performed additional ESD on the greater curvature in the antrum, which was

contralateral to the post-ESD site. d) The deformation was gradually released by the

contralateral traction that occurred during improvement of the new artificial ulcer. We

could observe the gastric lumen in the antrum.

Fig. 3. The flow chart of patients and lesions included in this study.

Table 1. Characteristics of 41 cases

Age

74(68-80)

Gender

Male

28

Female

13

Pyloric dissection

26

Angular dissection

11

Location

Lesser curve

26

Greater curve

Anterior wall

Posterior wall

Circumferential extent of mucosal defect, %

86 (83-95)

macroscopic type

elevated

28

depressed

13

invasion depth

mucosal

36

submucosal

Ulcer findings

10

Specimen diameter (mm)

60

Use of steroids

11

Deformation

Stenosis

36

Perforation by EBD

Data represents the number of patients or median (interquartile range)

EBD: Endoscopic balloon dilation

Table 2. Comparison of deformation and non-deformation (stenosis) cases

Age, years

Deformation (+)

Deformation (-)

n=5

n=34

69 (68-75)

p-value

74 (68-83)

Gender

0.64

female

11

male

25

Pyloric dissection

0.004

present

26

absent

10

Angular dissection

<0.001

present

absent

30

Location

0.63

Lesser curve

21

Greater curve

Anterior wall

Posterior wall

84 (83-90)

86 (82-95)

Circumferential extent of

mucosal defect (%)

0.34

Macroscopic type

0.79

0.30

elevated

26

depressed

10

Invasion depth

mucosal

31

submucosal

Ulcer findings

0.58

present

absent

28

Specimen diameter (mm)

110 (102-113)

57 (45-68)

Use of steroid

0.003

present

10

absent

26

Data represents the number of patients or median (interquartile range)

Table 3. Deformation cases depending on dissection range

Dissection range

Deformation rate

Angular dissection (+), Pyloric dissection (-)

63% (5/8)

Angular dissection (+), Pyloric dissection (+)

0% (0/3)

Angular dissection (-), Pyloric dissection (-)

0% (0/7)

Angular dissection (-), Pyloric dissection (+)

0% (0/23)

Data represents rate (Number of deformation cases/ Number of all cases)

Table 4. Characteristics of five cases with deformation

Specimen

No

diameter

(mm)

Circumferential

extent of the

mucosal defect

(%)

Number of

EBDs

(number)

Maximum

Diameter

of EBDs

(mm)

Period

Period from

from ESD

ESD to

to gastric

additional

stasis

treatment (day)

Additional

treatment

(day)

128

83

18

25

91

Distal gastrectomy

63

84

20

27

71

Distal gastrectomy

113

95

20

48

78

Gastrojejunostomy

102

90

14

20

41

125

EAP

102

83

20

46

157

EAP

EBD: Endoscopic balloon dilation, ESD: endoscopic submucosal dissection, EAP:

Endoscopic antralplasty

...

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