1 Wong AK, Joanna Nguyen T, Peric M, Shahabi A, Vidar EN, Hwang BH, et al. Analysis of risk factors associated with microvascular free flap failure using a multi-institutional da- tabase. Microsurgery. 2015;35:6-12. DOI: 10.1002/micr.22223, PMID: 24431159
2 Lese I, Biedermann R, Constantinescu M, Grobbelaar AO, Olariu R. Predicting risk factors that lead to free flap failure and vascular compromise: A single unit experience with 565 free tissue transfers. J Plast Reconstr Aesthet Surg. 2021;74:512-22. DOI: 10.1016/j.bjps.2020.08.126, PMID:33039304 Y. Suyama et al.
3 Golusinski P, Pazdrowski J, Szewczyk M, Pieńkowski P, Majchrzak E, Schneider A, et al. Multivariate analysis as an advantageous approach for prediction of the adverse outcome in head and neck microvascular reconstructive surgery. Am J Otolaryngol. 2017;38:148-52. DOI: 10.1016/ j.amjoto.2016.11.012, PMID: 27974173
4 Singh B, Cordeiro PG, Santamaria E, Shaha AR, Pfister DG, Shah JP. Factors associated with complications in microvas- cular reconstruction of head and neck defects. Plast Reconstr Surg. 1999;103:403-11. DOI: 10.1097/00006534-199902000- 00007, PMID: 9950525
5 Crawley MB, Sweeny L, Ravipati P, Heffelfinger R, Krein H, Luginbuhl A, et al. Factors associated with free flap failures in head and neck reconstruction. Otolaryngol Head Neck Surg. 2019;161:598-604. DOI: 10.1177/0194599819860809, PMID: 31382816
6 Buitrago G, Caballero F, Montealegre GE. Reconstruc- tion with free f laps of head and neck cancer defects: A national cohort study. Plast Reconstr Surg Glob Open. 2020;Publish Ahead of Print:e3018. DOI: 10.1097/ GOX.0000000000003018, PMID: 32983776
7 Jones NF, Jarrahy R, Song JI, Kaufman MR, Markowitz B. Postoperative medical complications--not microsurgical complications--negatively influence the morbidity, mortality, and true costs after microsurgical reconstruction for head and neck cancer. Plast Reconstr Surg. 2007;119:2053-60. DOI: 10.1097/01.prs.0000260591.82762.b5, PMID: 17519700
8 Offodile AC II, Aherrera A, Wenger J, Rajab TK, Guo L. Impact of increasing operative time on the incidence of early failure and complications following free tissue transfer? A risk factor analysis of 2,008 patients from the ACS-NSQIP database. Microsurgery. 2017;37:12-20. DOI: 10.1002/ micr.22387, PMID: 25752264
9 Ishimaru M, Ono S, Suzuki S, Matsui H, Fushimi K, Yasunaga H. Risk factors for free flap failure in 2,846 patients with head and neck cancer: A national database study in Japan. J Oral Maxillofac Surg. 2016;74:1265-70. DOI: 10.1016/ j.joms.2016.01.009, PMID: 26851310
10 Garip M, Van Dessel J, Grosjean L, Politis C, Bila M. The impact of smoking on surgical complications after head and neck reconstructive surgery with a free vascularised tissue flap: a systematic review and meta-analysis. Br J Oral Maxil- lofac Surg. 2021;59:e79-98. DOI: 10.1016/j.bjoms.2020.07.020, PMID: 33546845
11 Crippen MM, Brady JS, Mozeika AM, Eloy JA, Baredes S, Park RCW. Impact of body mass index on operative outcomes in head and neck free flap surgery. Otolaryngol Head Neck Surg. 2018;159:817-23. DOI: 10.1177/0194599818777240, PMID: 29807490
12 Cannady SB, Hatten KM, Bur AM, Brant J, Fischer JP, Newman JG, et al. Use of free tissue transfer in head and neck cancer surgery and risk of overall and serious complication(s): an American College of Surgeons-National Surgical Quality Improvement Project analysis of free tissue transfer to the head and neck. Head Neck. 2017;39:702-7. DOI: 10.1002/ hed.24669, PMID: 28000297
13 Las DE, de Jong T, Zuidam JM, Verweij NM, Hovius SER, Mureau MAM. Identification of independent risk factors for flap failure: A retrospective analysis of 1530 free flaps for breast, head and neck and extremity reconstruction. J Plast Reconstr Aesthet Surg. 2016;69:894-906. DOI: 10.1016/ j.bjps.2016.02.001, PMID: 26980600
14 Wang KY, Lin YS, Chen LW, Yang KC, Huang WC, Liu WC. Risk of free flap failure in head and neck reconstruc- tion: analysis of 21,548 cases from a nationwide database. Ann Plast Surg. 2020;84(suppl 1):S3-6. DOI: 10.1097/ SAP.0000000000002180, PMID: 31833882
15 Lin Y, He J, Zhang X, Wang H. Intraoperative factors associ- ated with free flap failure in the head and neck region: a four- year retrospective study of 216 patients and review of the literature. Int J Oral Maxillofac Surg. 2019;48:447-51. DOI: 10.1016/j.ijom.2018.08.009, PMID: 30195457
16 Lahtinen S, Koivunen P, Ala-Kokko T, Kaarela O, Ohtonen P, Laurila P, et al. Complications and outcome after free flap surgery for cancer of the head and neck. Br J Oral Maxillofac Surg. 2018;56:684-91. DOI: 10.1016/j.bjoms.2018.07.009, PMID: 30107953
17 Carroll WR, Esclamado RM. Ischemia/reperfusion injury in microvascular surgery. Head Neck. 2000;22:700-13. DOI: 10.1002/1097-0347(200010)22:7<700::AID-HED10>3.0.CO;2-H, PMID: 11002326
18 Barker JH, Acland RD, Anderson GL, Patel J. Microcircula- tory disturbances following the passage of emboli in an ex- perimental free-flap model. Plast Reconstr Surg. 1992;90:95-102. DOI: 10.1097/00006534-199207000-00014, PMID:1615097
19 Peter FW, Franken RJPM, Wang WZ, Anderson GL, Schuschke DA, O’Shaughnessy MM, et al. Effect of low dose aspirin on thrombus formation at arterial and venous microanastomoses and on the tissue microcirculation. Plast Reconstr Surg. 1997;99:1112-21. DOI: 10.1097/00006534- 199704000-00030, PMID: 9091911
20 Siemionow M, Arslan E. Ischemia/reperfusion injury: A review in relation to free tissue transfers. Microsurgery. 2004;24:468-75. DOI: 10.1002/micr.20060, PMID: 15378577
21 Büttemeyer R, Philipp AW, Mall JW, Ge B, Scheller FW, Lisdat F. In vivo measurement of oxygen-derived free radicals during reperfusion injury. Microsurgery. 2002;22:108-13. DOI: 10.1002/micr.21733, PMID: 11992497
22 Lee YC, Chen WC, Chen SH, Hung KS, Hsiao JR, Lee JW, et al. One versus two venous anastomoses in anterolateral thigh flap reconstruction after oral cancer ablation. Plast Reconstr Surg. 2016;138:481-9. DOI: 10.1097/PRS.0000000000002365, PMID: 27465170
23 Zhang T, Lubek J, Salama A, Caccamese J, Coletti D, Dyalram D, et al. Venous anastomoses using microvascular coupler in free flap head and neck reconstruction. J Oral Max- illofac Surg. 2012;70:992-6. DOI: 10.1016/j.joms.2011.02.111, PMID: 21741742
24 Christianto S, Lau A, Li KY, Yang WF, Su YX. One versus two venous anastomoses in microsurgical head and neck reconstruction: a cumulative meta-analysis. Int J Oral Maxil- lofac Surg. 2018;47:585-94. DOI: 10.1016/j.ijom.2018.01.006, PMID: 29395670
25 Shin JY, Roh SG, Lee NH, Yang KM. Is obesity a pre- disposing factor for free flap failure and complications? Comparison between breast and nonbreast reconstruction. Medicine (Baltimore). 2016;95:e4072. DOI: 10.1097/ MD.0000000000004072, PMID: 27368049
26 Heo YH, Yagi S, Toriyama K, Takanari K, Fujimoto Y, Nishio N, et al. Relationship between BMI and postoperative complications with free flap in anterolateral craniofacial reconstruction. Plast Reconstr Surg Glob Open. 2016;4:e636. DOI: 10.1097/GOX.0000000000000645, PMID: 27257566 Risk factors of free flap complications
27 Patel RS, McCluskey SA, Goldstein DP, Minkovich L, Irish JC, Brown DH, et al. Clinicopathologic and therapeutic risk factors for perioperative complications and prolonged hospital stay in free flap reconstruction of the head and neck. Head Neck. 2010;32:1345-53. DOI: 10.1002/hed.21331, PMID: 20091687
28 Kao HK, Guo LF, Cheng MH, Chen IH, Liao CT, Fang KH, et al. Predicting postoperative morbidity and mortality by model for endstage liver disease score for patients with head and neck cancer and liver cirrhosis. Head Neck. 2011;33:529-34. DOI: 10.1002/hed.21486, PMID: 20665744
29 Yagi S, Suyama Y, Fukuoka K, Takeuchi H, Kitano H. Recipient vessel selection in head and neck reconstruction based on the type of neck dissection. Yonago Acta Med. 2016;59:159-62. PMID: 27493487
30 Thorpe E, Patil Y. Mechanical venous anastomosis in head and neck microvascular reconstruction as an equivalent to the gold standard. Ear Nose Throat J. 2017;96:E32-6. DOI: 10.1177/014556131709600217, PMID: 28231374
31 El Baba B, Watfa W, Youssef L, Di Summa PG, Bou Khalil P, Jurjus AR, et al. Review and update on the use of the microanastomotic coupler device for arterial anastomosis in free tissue transfer. Br J Oral Maxillofac Surg. 2021;59:16-20. DOI: 10.1016/j.bjoms.2020.06.019, PMID: 32620301
32 Aldekhayel S, Alshomer F, Alhazmi B. Venous coupler in pediatric free tissue transfer: case series and literature review. Plast Reconstr Surg Glob Open. 2020;8:e2647. DOI: 10.1097/ GOX.0000000000002647, PMID: 32309092
33 Chiu TH, Tsao CK, Chang SN, Lin JW, Hwang JJ. Clinical consequences of head and neck free-flap reconstructions in the DM population. Sci Rep. 2021;11:6034. DOI: 10.1038/ s41598-021-85410-3, PMID: 33727645