Successful conservative treatment for massive uterine bleeding with non-septic disseminated intravascular coagulation after termination of early pregnancy in a woman with huge adenomyosis: case report.

1. Feinstein DI. Disseminated intravascular coagulation in patients with solid

tumors. Oncology. 2015;29:96–102.

2. Levi M. Management of cancer-associated disseminated intravascular

coagulation. Thromb Res. 2016;140(Suppl 1):S66–70.

3. Franchini M, Di Minno MN, Coppola A. Disseminated intravascular

coagulation in hematologic malignancies. Semin Thromb Hemost. 2010;36:

388–403.

4. Cunningham FG, Nelson DB. Disseminated intravascular coagulation

syndromes in obstetrics. Obstet Gynecol. 2015;126:999–1011. https://doi.org/

10.1097/AOG.0000000000001110.

5. Erez O, Mastrolia SA, Thachil J. Disseminated intravascular coagulation in

pregnancy: insights in pathophysiology, diagnosis and management. Am J

Obstet Gynecol. 2015;213:452–63. https://doi.org/10.1016/j.ajog.2015.03.054.

6. Antovic J, Bakic M, Milicevic R, Gojkovic G, Blombäck M. Activation of the

coagulation system occurs within rather than outside cutaneous

haemangiomas. Acta Paediatr. 2001;90:1137–40.

7. Nakamura Y, Kawamura N, Ishiko O, Ogita S. Acute disseminated

intravascular coagulation developed during menstruation in an

adenomyosis patient. Arch Gynecol Obstet. 2002;267:110–2.

8. Zhang J, Xiao X, Luo F, Shi G, He Y, Yao Y, Xu L. Acute disseminated

intravascular coagulation developed after dilation and curettage in an

23.

24.

25.

26.

27.

adenomyosis patient: a case report. Blood Coagul Fibrinolysis. 2013;24:771–

3. https://doi.org/10.1097/MBC.0b013e3283641917.

García-Solares J, Donnez J, Donnez O, Dolmans MM. Pathogenesis of

uterine adenomyosis: invagination or metaplasia? Fertil Steril. 2018;109:371–

9. https://doi.org/10.1016/j.fertnstert.2017.12.030.

Pontis A, D’Alterio MN, Pirarba S, de Angelis C, Tinelli R, Angioni S.

Adenomyosis: a systematic review of medical treatment. Gynecol

Endocrinol. 2016;32:696–700.

Struble J, Reid S, Bedaiwy MA. Adenomyosis: a clinical review of a

challenging gynecologic condition. J Minim Invasive Gynecol. 2016;23:164–

85. https://doi.org/10.1016/j.jmig.2015.09.018.

Devlieger R, D'Hooghe T, Timmerman D. Uterine adenomyosis in the

infertility clinic. Hum Reprod Update. 2003;9:139–47.

Krychtiuk KA, Kastl SP, Speidl WS, Wojta J. Inflammation and coagulation in

atherosclerosis. Hamostaseologie. 2013;33:269–82.

Simmons J, Pittet JF. The coagulopathy of acute sepsis. Curr Opin

Anaesthesiol. 2015;28:227–36.

Reikerås O, Borgen P. Activation of markers of inflammation, coagulation

and fibrinolysis in musculoskeletal trauma. PLoS One. 2014;9:e107881.

Yamanaka A, Kimura F, Yoshida T, Kita N, Takahashi K, Kushima R, et al.

Dysfunctional coagulation and fibrinolysis systems due to adenomyosis is a

possible cause of thrombosis and menorrhagia. Eur J Obstet Gynecol

Reprod Biol. 2016;204:99–103. https://doi.org/10.1016/j.ejogrb.2016.07.499.

Yamashiro K, Tanaka R, Nishioka K, Ueno Y, Shimura H, Okuma Y, et al.

Cerebral infarcts associated with adenomyosis among middle-aged women.

J Stroke Cerebrovasc Dis. 2012;21:910.e1–5. https://doi.org/10.1016/j.

jstrokecerebrovasdis.2011.10.017.

Lee JY, Hwang KR, Won KH, Lee DY, Jeon HW, Moon MH. Uterine infarction

in a patient with uterine adenomyosis following biochemical pregnancy.

Clin Exp Reprod Med. 2014;41:174–7. https://doi.org/10.5653/cerm.2014.41.4.

174.

Shimada M, Matsumata T, Shirabe K, Kamakura T, Taketomi A, Sugimachi K.

Effect of nafamostat mesilate on coagulation and fibrinolysis in hepatic

resection. J Am Coll Surg. 1994;178:498–502.

Sundaram S, Gikakis N, Hack CE, Niewiarowski S, Edmunds LH Jr, Koneti Rao

A, et al. Nafamostat mesilate, a broad spectrum protease inhibitor,

modulates platelet, neutrophil and contact activation in simulated

extracorporeal circulation. Thromb Haemost. 1996;75:76–82.

Choi JY, Kang YJ, Jang HM, Jung HY, Cho JH, Park SH, et al. Nafamostat

Mesilate as an Anticoagulant During Continuous Renal Replacement

Therapy in Patients With High Bleeding Risk: A Randomized Clinical Trial.

Medicine (Baltimore). 2015;94:e2392.

Taneichi A, Fujiwara H, Mizoguchi Y, Machida S, Nonaka H, Takei Y, et al.

Disseminated intravascular coagulopathy caused by uterine leiomyoma with

sarcoma-like findings on magnetic resonance imaging. Case Rep Obstet

Gynecol. 2014;2014:978743.

Mukaiyama H, Shionoya S, Ikezawa T, Kamiya T, Hamaguchi M, Saito H.

Abdominal aortic aneurysm complicated with chronic disseminated

intravascular coagulopathy: a case of surgical treatment. J Vasc Surg. 1987;6:

600–4.

Asakura H. Classifying types of disseminated intravascular coagulation:

clinical and animal models. J Intensive Care. 2014;2:20.

Fujii S, Hitomi Y. New synthetic inhibitors of C1r, C1 esterase, thrombin,

plasmin, kallikrein and trypsin. Biochim Biophys Acta. 1981;661:342–5.

Aoyama T, Ino Y, Ozeki M, Oda M, Sato T, Koshiyama Y, et al.

Pharmacological studies of FUT-175, nafamstat mesilate. I. Inhibition of

protease activity in in vitro and in vivo experiments. Jpn J Pharmacol. 1984;

35:203–27.

Shimokawa Miyama T, Yoshioka C, Minami K, Okawa T, Hiraoka H, Itamoto K,

et al. Nafamostat mesilate is not appropriate as an anticoagulant during

continuous renal replacement therapy in dogs. J Vet Med Sci. 2010;72:363–

7.

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