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Pattern of THK 5351 retention in normal aging involves core regions of resting state networks associated with higher cognitive function

Yoshida, Yusuke Yokoi, Takamasa Hara, Kazuhiro Watanabe, Hirohisa Yamaguchi, Hiroshi Bagarinao, Epifanio Masuda, Michihito Kato, Toshiyasu Ogura, Aya Ohdake, Reiko Kawabata, Kazuya Katsuno, Masahisa Kato, Katsuhiko Naganawa, Shinji Okamura, Nobuyuki Yanai, Kazuhiko Sobue, Gen 名古屋大学

2023.11

概要

Recent progress in imaging techniques, such as positron emission tomography (PET) and
magnetic resonance imaging (MRI), has enabled the visualization of not only amyloid β and
tau deposition, but also astrogliosis and alterations to anatomical and functional brain networks.
These imaging techniques have enabled researchers to examine simultaneously the deposition
patterns of abnormal proteins, gray matter atrophic changes, and functional alterations in living
diseased brain.
[18F]THK 5351 was initially developed as a tau tracer1 but became recognized mainly as a
monoamine oxidase-B (MAO-B) tracer.2,3 Its retention corresponded well to the known distribution of tau related to astrogliosis and to increased MAO-B associated with the clinical severity
and symptomatology of cognitive decline.1,3,4 Head-to-head comparison study demonstrated that
THK5351 was superior to C-L-deprenyl for visualizing lesions undergoing astrogliosis.5
Resting-state functional MRI (fMRI) has also proven to be very useful in examining the
brain connectome of both healthy subjects and patients. Alterations in the brain connectome
have been associated with psychiatric6,7 and neurodegenerative disorders.8-14 In the case of
Alzheimer’s disease (AD), associations with pathologic proteins and brain network changes have
been extensively investigated.15,16
Subprofile modeling/principal component analysis (SSM/PCA) is an unbiased data-driven
multivariate PCA-based approach. It enables us to identify major sources of variation in the brain
image data of both patients and control groups, to reduce the complexity of multivariate data.17-19
Using SSM/PCA, we identified a disease-specific spatial pattern of THK 5351 retention
composed mainly of three clusters, the precuneus/posterior cingulate cortex, and the right and
left dorsolateral prefrontal cortex.13 Disruption of the functional connections of the precuneus/
posterior cingulate cortex, which showed one of the highest retention rates of THK 5351, may
play an essential role in the development of dementia.
Only a limited number of imaging studies have explicitly investigated the association between
abnormal THK 5351 deposition, volumetric changes, and functional alterations in aging. Recently,
Shigemoto et al reported a significant negative correlation between THK 5351 accumulation and
gray matter volume in the bilateral medial temporal lobes.20 However, the spatial pattern of THK
5351 retention in healthy older adults has not been clearly elucidated. Besides, the relationship
between THK 5351 retention and resting state networks (RSNs) as assessed by MRI in healthy
subjects remains poorly understood.
Nagoya J. Med. Sci. 85. ...

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References End

Nagoya J. Med. Sci. 85. 758–771, 2023

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doi:10.18999/nagjms.85.4.758

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Pattern of THK 5351 retention in normal aging involves core regions of resting state networks associated with higher cognitive function

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Pattern of THK 5351 retention in normal aging involves core regions of resting state networks associated with higher cognitive function

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関連論文

Alterations in DNA methylation rates of brain-derived neurotrophic factor in patients with schizophrenia.

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参考文献