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大学・研究所にある論文を検索できる 「Distinct features between HLA-DR+ and HLA-DR- PD-1hi CXCR5- T peripheral helper cells in seropositive rheumatoid arthritis (本文)」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

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Distinct features between HLA-DR+ and HLA-DR- PD-1hi CXCR5- T peripheral helper cells in seropositive rheumatoid arthritis (本文)

山田, 裕揮 慶應義塾大学

2021.03.23

概要

Objectives. PD-1hi CXCR5– T peripheral helper (Tph) cells are newly identified pathogenic CD4 helper T cells in RA. We evaluated the usefulness of Tph cell subsets as biomarkers of RA.

Methods. RA patients who visited our rheumatology department between May 2015 and September 2017 and met the 2010 ACR/EULAR classification criteria were included. We compared the correlation of DAS28-ESR between Tph cell subsets and 40 immune cell subsets. We also explored which subsets reflected the chronological changes in the disease activity after treatment.

Results. Thirty-four seropositive RA patients, 11 seronegative RA patients and 34 healthy controls were included. Tph cell subsets that correlated with the DAS28-ESR were HLA-DRþ Tph cells (rs¼ 0.50, P ¼ 0.002), HLA-DR– Tph cells (rs ¼ 0.39, P ¼ 0.03) and Tph1 cells (rs ¼ 0.41, P ¼ 0.02). Among the other 40 immune cell subsets, HLA-DRþ Th1-17 cells (rs ¼ 0.38, P ¼ 0.03), activated B cells (rs ¼ –0.35, P ¼ 0.04), plasma cells (rs ¼ 0.43, P ¼ 0.01) and CD14þþ CD16þ monocytes (rs ¼ 0.36, P ¼ 0.04) correlated, but not strongly as HLA-DRþ Tph cells. However, MTX treatment reduced the proportion of HLA-DRþ Tph cells independently of the disease activity. In contrast, HLADR– Tph cells accurately reflected the change in the DAS28-ESR during MTX treatment.

Conclusion. HLA-DRþ Tph cells were decreased with MTX treatment, independent of the disease activity, while HLA-DR– Tph cells reflected the disease activity accurately during the treatment.

参考文献

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