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Glucocorticoid in Combination with a TNF-α Inhibitor: Treatment of Deep Vein Thrombosis in a Patient with Behçet's Disease

Okano, Mitsumasa Yoneda, Katsuhiko Ichise, Yoshihide Kusuhara, Sentaro Muramae, Naokazu Mori, Kenta Otsui, Kazunori Sakaguchi, Kazuhiko 神戸大学

2023.07.01

概要

A 38-year-old man with deep vein thrombosis associated with Behçet's disease (BD) was admitted to our hospital due to worsening symptoms despite the initiation of direct oral anticoagulants (DOACs). Administration of oral prednisolone and an intravenous anti-tumor necrosis factor-alpha (TNF-α) monoclonal antibody dramatically improved his symptoms. In addition, he was incidentally diagnosed with autosomal dominant polycystic kidney disease, which increases the risk of aortic aneurysms. BD also increases the risk of aortic aneurysms. This case suggests that immunosuppressive treatment is effective in patients with inflammation-related DOAC-refractory venous thrombosis who also suffer from BD.

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参考文献

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The Internal Medicine is an Open Access journal distributed under the Creative

Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To

view the details of this license, please visit (https://creativecommons.org/licenses/

by-nc-nd/4.0/).

Ⓒ 2023 The Japanese Society of Internal Medicine

Intern Med 62: 2009-2012, 2023

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