Design, Synthesis and Biological Evaluation of Novel Quinoline Based Small Molecules as Anticancer Agents Targeting Topoisomerase I
概要
Thesis Abstract
Design, Synthesis and Biological Evaluation of Novel Quinoline Based Small
Molecules as Anticancer Agents Targeting Topoisomerase I
(ࢺ࣏ࢯ࣓࣮ࣛࢮ I 㜼ᐖ⸆ࢆ┠ᣦࡋࡓ࢟ࣀࣜࣥㄏᑟయࡢタィࠊྜᡂࠊ⏕≀άᛶ)
Mostafa Mohamed Mostafa Elbadawi
2021
Department of Chemistry,
Graduate School of Science,
Hiroshima University
Content of the thesis
Preface
Abstract
Chapter 1 Introduction
Chapter 2
Discovery of 4-alkoxy-2-aryl-6,7-dimethoxyquinolines as
topoisomerase I poisons lead compounds with potential in vitro
anticancer activity
Chapter 3 Development of potential anticancer agents through structural
modification of 2-aryl-4-propoxymorpholine- 6,7-dimethoxyquinolines
Chapter 4 Design, synthesis and biological evaluation of benzofuroquinolines as
potential anticancer agents through structural modification of
2-(p-chlorophenyl)-4-propoxymorpholine-6,7-dimethoxyquinoline
Summary
References
Acknowledgement
List of publications