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Histological diagnostic criterion for chronic endometritis based on the clinical outcome.

HIRATA Kimiko KIMURA Fuminori 90322148 0000-0002-9840-4227 NAKAMURA Akiko 70839430 KITAZAWA Jun 30823900 MORIMUNE Aina 60757219 HANADA Tetsuro 0000-0001-8183-9702 TAKEBAYASHI Akie 00402735 0000-0001-6426-9082 TAKASHIMA Akiko 20452245 AMANO Tsukuru 20613467 0000-0003-2919-6337 TSUJI Shunichiro 30601546 0000-0003-3945-6817 KAKU Shoji 50464178 KUSHIMA Ryoji 40252382 MURAKAMI Takashi 20240666 0000-0002-0250-0856 滋賀医科大学

2021.03.04

概要

Background:
The diagnostic criteria of chronic endometritis remain controversial in the treatment for infertile patients.
Methods:
A prospective observational study was conducted in a single university from June 2014 to September 2017. Patients who underwent single frozen-thawed blastocyst transfer with a hormone replacement cycle after histological examination for the presence of chronic endometritis were enrolled. Four criteria were used to define chronic endometritis according to the number of plasma cells in the same group of patients: 1 or more (≥ 1) plasma cells, 2 or more (≥ 2), 3 or more (≥ 3), or 5 or more (≥ 5) in 10 high-power fields. Pregnancy rates, live birth rates, and miscarriage rates of the non-chronic endometritis and the chronic endometritis groups defined with each criterion were calculated. A logistic regression analysis was performed for live births using eight explanatory variables (seven infertility factors and chronic endometritis). A receiver operating characteristic curve was drawn and the optimal cut-off value was calculated.
Results:
A total of 69 patients were registered and 53 patients were finally analyzed after exclusion. When the diagnostic criterion was designated as the presence of ≥ 1 plasma cell in the endometrial stroma per 10 high-power fields, the pregnancy rate, live birth rate, and miscarriage rate were 63.0% vs. 30.8%, 51.9% vs. 7.7%, and 17.7% vs. 75% in the non-chronic and chronic endometritis groups, respectively. This criterion resulted in the highest pregnancy and live birth rates among the non-chronic endometritis and the smallest P values for the pregnancy rates, live birth rates, and miscarriage rates between the non-chronic and chronic endometritis groups. In the logistic regression analysis, chronic endometritis was an explanatory variable negatively affecting the objective variable of live birth only when chronic endometritis was diagnosed with ≥ 1 or ≥ 2 plasma cells per 10 high-power fields. The optimal cut-off value was obtained when one or more plasma cells were found in 10 high-power fields (sensitivity 87.5%, specificity 64.9%).
Conclusions:
Chronic endometritis should be diagnosed as the presence of ≥ 1 plasma cells in 10 high-power fields. According to this diagnostic criterion, chronic endometritis adversely affected the pregnancy rate and the live birth rate.

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参考文献

1. Kaku S, Kubo T, Kimura F, Nakamura A, Kitazawa J, Morimune A, et al.

Relationship of chronic endometritis with chronic deciduitis in cases of

miscarriage. BMC Womens Health. 2020;20(1):114.

2. Xu Y, Mei J, Diao L, Li Y, Ding L. Chronic endometritis and reproductive

failure: Role of syndecan-1. Am J Reprod Immunol. 2020;84(3):e13255.

3. Kimura F, Takebayashi A, Ishida M, Nakamura A, Kitazawa J, Morimune

A, et al. Review: Chronic endometritis and its effect on reproduction. J

Obstet Gynaecol Res. 2019;45(5):951–60.

4. Smith M, Hagerty KA, Skipper B, Bocklage T. Chronic endometritis: a combined histopathologic and clinical review of cases from 2002 to 2007. Int

J Gynecol Pathol. 2010;29(1):44–50.

5. Kasius JC, Fatemi HM, Bourgain C, Sie-Go DM, Eijkemans RJ, Fauser BC,

et al. The impact of chronic endometritis on reproductive outcome. Fertil

Steril. 2011;96(6):1451–6.

6. Kitaya K, Yasuo T. Immunohistochemistrical and clinicopathological characterization of chronic endometritis. Am J Reprod Immunol.

2011;66(5):410–5.

7. Horton L, Wilkes J. Letter: Chronic non-specific endometritis. Lancet.

1976;2(7981):366.

8. Johnston-MacAnanny EB, Hartnett J, Engmann LL, Nulsen JC, Sanders

MM, Benadiva CA. Chronic endometritis is a frequent finding in women

with recurrent implantation failure after in vitro fertilization. Fertil Steril.

2010;93(2):437–41.

9. McQueen DB, Bernardi LA, Stephenson MD. Chronic endometritis in

women with recurrent early pregnancy loss and/or fetal demise. Fertil

Steril. 2014;101(4):1026–30.

10. Cicinelli E, Matteo M, Tinelli R, Lepera A, Alfonso R, Indraccolo U, et al.

Prevalence of chronic endometritis in repeated unexplained implantation failure and the IVF success rate after antibiotic therapy. Hum Reprod.

2015;30(2):323–30.

11. Bouet PE, El Hachem H, Monceau E, Gariepy G, Kadoch IJ, Sylvestre C.

Chronic endometritis in women with recurrent pregnancy loss and recurrent implantation failure: prevalence and role of office hysteroscopy and

immunohistochemistry in diagnosis. Fertil Steril. 2016;105(1):106–10.

12. Cicinelli E, Resta L, Nicoletti R, Tartagni M, Marinaccio M, Bulletti C, et al.

Detection of chronic endometritis at fluid hysteroscopy. J Minim Invasive

Gynecol. 2005;12(6):514–8.

13. Cicinelli E, Matteo M, Trojano G, Mitola PC, Tinelli R, Vitagliano A, et al.

Chronic endometritis in patients with unexplained infertility: prevalence

and effects of antibiotic treatment on spontaneous conception. Am J

Reprod Immunol. 2018;79(1):e12782.

14. Liu Y, Chen X, Huang J, Wang CC, Yu MY, Laird S, et al. Comparison of the

prevalence of chronic endometritis as determined by means of different

diagnostic methods in women with and without reproductive failure.

Fertil Steril. 2018;109(5):832–9.

15. Song D, Feng X, Zhang Q, Xia E, Xiao Y, Xie W, et al. Prevalence and

confounders of chronic endometritis in premenopausal women with

abnormal bleeding or reproductive failure. Reprod Biomed Online.

2018;36(1):78–83.

16. Tersoglio AE, Salatino DR, Reinchisi G, Gonzalez A, Tersoglio S, Marlia C.

Repeated implantation failure in oocyte donation. What to do to improve

the endometrial receptivity? JBRA Assist Reprod. 2015;19(2):44–52.

17. Yang R, Du X, Wang Y, Song X, Yang Y, Qiao J. The hysteroscopy and

histological diagnosis and treatment value of chronic endometritis in recurrent implantation failure patients. Arch Gynecol Obstet.

2014;289(6):1363–9.

18. McQueen DB, Perfetto CO, Hazard FK, Lathi RB. Pregnancy outcomes in

women with chronic endometritis and recurrent pregnancy loss. Fertil

Steril. 2015;104(4):927–31.

19. Vitagliano A, Saccardi C, Noventa M, Di Spiezio Sardo A, Saccone G,

Cicinelli E, et al. Effects of chronic endometritis therapy on in vitro

fertilization outcome in women with repeated implantation failure: a

systematic review and meta-analysis. Fertil Steril. 2018;110(1):103–12 e1.

20. Morimune A, Kimura F, Nakamura A, Kitazawa J, Takashima A, Amano T,

et al. The effects of chronic endometritis on the pregnancy outcomes.

Am J Reprod Immunol. 2020;75:e13357.

21. Klatsky PC, Tran ND, Caughey AB, Fujimoto VY. Fibroids and reproductive

outcomes: a systematic literature review from conception to delivery. Am

J Obstet Gynecol. 2008;198(4):357–66.

Page 10 of 11

22. Youm HS, Choi YS, Han HD. In vitro fertilization and embryo transfer

outcomes in relation to myometrial thickness. J Assist Reprod Genet.

2011;28(11):1135–40.

23. Chan YY, Jayaprakasan K, Tan A, Thornton JG, Coomarasamy A, RaineFenning NJ. Reproductive outcomes in women with congenital

uterine anomalies: a systematic review. Ultrasound Obstet Gynecol.

2011;38(4):371–82.

24. Alansari LM, Wardle P. Endometrial polyps and subfertility. Hum Fertil

(Camb). 2012;15(3):129–33.

25. Strandell A, Lindhard A, Waldenstrom U, Thorburn J, Janson PO, Hamberger L. Hydrosalpinx and IVF outcome: a prospective, randomized multicentre trial in Scandinavia on salpingectomy prior to IVF. Hum Reprod.

1999;14(11):2762–9.

26. Craciunas L, Gallos I, Chu J, Bourne T, Quenby S, Brosens JJ, et al. Conventional and modern markers of endometrial receptivity: a systematic

review and meta-analysis. Hum Reprod Update. 2019;25(2):202–23.

27. Busnelli A, Paffoni A, Fedele L, Somigliana E. The impact of thyroid autoimmunity on IVF/ICSI outcome: a systematic review and meta-analysis.

Hum Reprod Update. 2016;22(6):793–4.

28. Simon A, Laufer N. Assessment and treatment of repeated implantation

failure (RIF). J Assist Reprod Genet. 2012;29(11):1227–39.

29. Coughlan C, Ledger W, Wang Q, Liu F, Demirol A, Gurgan T, et al. Recurrent implantation failure: definition and management. Reprod Biomed

Online. 2014;28(1):14–38.

30. van Dijk MM, Kolte AM, Limpens J, Kirk E, Quenby S, van Wely M, et al.

Recurrent pregnancy loss: diagnostic workup after two or three pregnancy losses? A systematic review of the literature and meta-analysis.

Hum Reprod Update. 2020;26(3):356–67.

31. Takebayashi A, Kimura F, Kishi Y, Ishida M, Takahashi A, Yamanaka A, et al.

The association between endometriosis and chronic endometritis. PLoS

ONE. 2014;9(2):e88354.

32. Wu D, Kimura F, Zheng L, Ishida M, Niwa Y, Hirata K, et al. Chronic endometritis modifies decidualization in human endometrial stromal cells.

Reprod Biol Endocrinol. 2017;15(1):16.

33. Goto S, Kadowaki T, Hashimoto H, Kokeguchi S, Shiotani M. Stimulation of

endometrium embryo transfer (SEET): injection of embryo culture supernatant into the uterine cavity before blastocyst transfer can improve

implantation and pregnancy rates. Fertil Steril. 2007;88(5):1339–43.

34. Kitaya K, Yasuo T. Aberrant expression of selectin E, CXCL1, and CXCL13 in

chronic endometritis. Mod Pathol. 2010;23(8):1136–46.

35. Kitaya K, Matsubayashi H, Takaya Y, Nishiyama R, Yamaguchi K, Takeuchi

T, et al. Live birth rate following oral antibiotic treatment for chronic

endometritis in infertile women with repeated implantation failure. Am J

Reprod Immunol. 2017;78(5):e12719.

36. Li Y, Xu S, Yu S, Huang C, Lin S, Chen W, et al. Diagnosis of chronic

endometritis: How many CD138(+) cells/HPF in endometrial stroma

affect pregnancy outcome of infertile women? Am J Reprod Immunol.

2020;10:e13369.

37. Fan X, Li X, Li Y, Liao J, Chen H, Li Y, et al. Endometrial CD138 count

appears to be a negative prognostic indicator for patients who

have experienced previous embryo transfer failure. Fertil Steril.

2019;112(6):1103–11.

38. Griesinger G, Blockeel C, Sukhikh GT, Patki A, Dhorepatil B, Yang DZ, et al.

Oral dydrogesterone versus intravaginal micronized progesterone gel

for luteal phase support in IVF: a randomized clinical trial. Hum Reprod.

2018;33(12):2212–21.

39. Barbosa MWP, Valadares NPB, Barbosa ACP, Amaral AS, Iglesias JR, Nastri

CO, et al. Oral dydrogesterone vs. vaginal progesterone capsules for

luteal-phase support in women undergoing embryo transfer: a systematic review and meta-analysis. JBRA Assist Reprod. 2018;22(2):148–56.

40. Zhu X, Ye H, Fu Y. Duphaston and human menopausal gonadotropin

protocol in normally ovulatory women undergoing controlled ovarian

hyperstimulation during in vitro fertilization/intracytoplasmic sperm

injection treatments in combination with embryo cryopreservation. Fertil

Steril. 2017;108(3):505–12 e2.

41. Kitazawa J, Kimura F, Nakamura A, Morimune A, Takahashi A, Takashima

A, et al. Endometrial immunity for embryo implantation and pregnancy

establishment. Tohoku J Exp Med. 2020;250(1):49–60.

42. Puente E, Alonso L, Lagana AS, Ghezzi F, Casarin J, Carugno J. Chronic

endometritis: old problem, novel insights and future challenges. Int J

Fertil Steril. 2020;13(4):250–6.

Hirata et al. BMC Women’s Health

(2021) 21:94

43. Drizi A, Djokovic D, Lagana AS, van Herendael B. Impaired inflammatory state of the endometrium: a multifaceted approach to endometrial

inflammation Current insights and future directions. Prz Menopauzalny.

2020;19(2):90–100.

44. Matteo M, Cicinelli E, Greco P, Massenzio F, Baldini D, Falagario T, et al.

Abnormal pattern of lymphocyte subpopulations in the endometrium

of infertile women with chronic endometritis. Am J Reprod Immunol.

2009;61(5):322–9.

45. Li Y, Yu S, Huang C, Lian R, Chen C, Liu S, et al. Evaluation of peripheral and

uterine immune status of chronic endometritis in patients with recurrent

reproductive failure. Fertil Steril. 2020;113(1):187–96 e1.

Page 11 of 11

46. Kitazawa J, Kimura F, Nakamura A, Morimune A, Hanada T, Amano T, et al.

Alteration in endometrial helper T-cell subgroups in chronic endometritis.

Am J Reprod Immunol. 2020;5:e13372.

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