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Clear Cell Squamous Cell Carcinoma of the Maxillary Gingiva Associated with PIK3CA and HRAS Mutations: Report of a Case and Literature Review

Hirose, Katsutoshi 大阪大学

2023.09.21

概要

An 89-year-old female was referred to the Osaka University Dental Hospital for painful swelling in the upper
right gingival region. The patient had noticed a gingival
mass for 1 month and had no significant medical history. Intraoral examination revealed an approximately
60 × 40 mm lobulated mass with an ulcerative surface
on the right maxillary posterior gingiva extending to the
buccal mucosa (Fig. 1a). Computed tomography (CT)
revealed an infiltrative lesion with maxillary bone resorption (Fig. 1b, c). With a provisional diagnosis of SCC,
an incisional biopsy was performed (Fig. 2) followed by
segmental maxillectomy (Fig. 3). The tumor recurred after
3 months, and the patient died 8 months after surgery due
to complications related to disease recurrence (Table 1).
Fig. 2 Histological findings of the biopsy. The exophytic tumor mass
showed a penetrating growth pattern, resulting in several deep crypts
filled with keratin debris (b was the black dotted-box area in a). c
The tumor cells featured abundant clear cytoplasm, especially from
the parabasal cells to the surface epithelium. d Clear cells exhibited
enlarged and centrally placed round nuclei and nuclear and cellular
atypia. ...

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Publisher's Note Springer Nature remains neutral with regard to

jurisdictional claims in published maps and institutional affiliations.

Authors and Affiliations

Katsutoshi Hirose1 · Takumi Shibahara1,2 · Akari Teramoto1,2 · Yu Usami1 · Sawako Ono3 · Yuri Iwamoto4 ·

Shumei Murakami4 · Kaori Oya5 · Narikazu Uzawa2 · Daisuke Motooka6 · Yumiko Hori7,8 · Eiichi Morii7 ·

Satoru Toyosawa1

* Katsutoshi Hirose

hirose.katsutoshi.dent@osaka-u.ac.jp

Satoru Toyosawa

toyosawa.satoru.dent@osaka-u.ac.jp

Takumi Shibahara

u395284j@ecs.osaka-u.ac.jp

Department of Oral and Maxillofacial Pathology, Osaka

University Graduate School of Dentistry, 1‑8 Yamadaoka,

Suita, Osaka 565‑0871, Japan

Department of Oral & Maxillofacial Oncology and Surgery,

Osaka University Graduate School of Dentistry, 1‑8

Yamadaoka, Suita, Osaka 565‑0871, Japan

Department of Pathology and Medicine, Graduate School

of Medicine, Dentistry and Pharmaceutical Sciences,

Okayama University, Okayama 700‑8558, Japan

Department of Oral and Maxillofacial Radiology, Osaka

University Graduate School of Dentistry, 1‑8 Yamadaoka,

Suita, Osaka 565‑0871, Japan

Clinical Laboratory, Osaka University Dental Hospital, 1‑8

Yamadaoka, Suita, Osaka 565‑0871, Japan

Daisuke Motooka

daisukem@gen-info.osaka-u.ac.jp

Genome Information Research Center, Research Institute

for Microbial Diseases, Osaka University, 3‑1 Yamadaoka,

Suita, Osaka 565‑0871, Japan

Yumiko Hori

yumiko-hori@molpath.med.osaka-u.ac.jp

Department of Pathology, Osaka University Graduate School

of Medicine, 2‑2 Yamadaoka, Suita, Osaka 565‑0871, Japan

Department of Central Laboratory and Surgical Pathology,

National Hospital Organization, Osaka National Hospital,

2‑1‑14 Hoenzaka, Chuo‑ku, Osaka 540‑0006, Japan

Akari Teramoto

u970049j@ecs.osaka-u.ac.jp

Yu Usami

usami.yuu.dent@osaka-u.ac.jp

Sawako Ono

de19008@s.okayama-u.ac.jp

Yuri Iwamoto

nishikawa.yuri.dent@osaka-u.ac.jp

Shumei Murakami

murakami.shumei.dent@osaka-u.ac.jp

Kaori Oya

ooya.kaori.dent@osaka-u.ac.jp

Narikazu Uzawa

uzawa.narikazu.dent@osaka-u.ac.jp

Eiichi Morii

morii@molpath.med.osaka-u.ac.jp

13

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