リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

大学・研究所にある論文を検索できる 「Current Status and Problems of Newborn Infection Management at a Regional Hospital in Japan」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

コピーが完了しました

URLをコピーしました

論文の公開元へ論文の公開元へ
書き出し

Current Status and Problems of Newborn Infection Management at a Regional Hospital in Japan

Ninchoji, Takeshi Okuno, Masayo Kihara, Tomoko Takekida, Shigeki Maruyama, Jun 神戸大学

2023

概要

PURPOSE: To clarify neonatal bacterial infection management in near term and term infants at a regional hospital in Japan. METHODS: Between 2018 and 2020, of 729 births, 236 patients who underwent blood examination at least twice by the age of 3 days, were included. Data from the medical records were analyzed retrospectively. RESULTS: Median gestational age was 39 weeks, with 116 boys (49.1%) and 202 vaginal deliveries (85.6%). There were 37 cases of maternal group B streptococcus, 24 cases of premature rupture of membranes for more than 24 hours (PROM group), and 107 cases of amniotic fluid turbidity at birth (AFT group). Comparing groups, C-reactive protein (CRP) was significantly lower in the cesarean section (C/S) group (median 0.22 mg/dL; p < 0.05), and higher in the AFT group (0.44 mg/dL; p < 0.05). There were 77 positive cultures, (p < 0.05). Antibiotics were administered more frequently in cesarean section (19 cases; p < 0.001) and less in the PROM group (2 cases; p < 0.01). CONCLUSIONS: There were no asymptomatic cases of CRP >2 mg/dL, and no cases of severe sepsis in normal neonatal deliveries. CRP levels were elevated in the AFT group, where culture was positive, but few antibiotics were administered. In the C/S group, antibiotics were administered if respiratory symptoms occurred unless the CRP level was high. Further, all patients in PROM group who received antibiotics had any symptoms, suggesting that routine blood tests may not be necessary.

この論文で使われている画像

参考文献

1. Lawn JE, Blencowe H, Oza S, You D, Lee AC, Waiswa P, et al. Every Newborn: progress, priorities, and

potential beyond survival. Lancet. 2014;384(9938):189–205.

2. Rahman AE, Hossain AT, Zaman SB, Salim N, KC. A, Day LT, et al. Antibiotic use for inpatient newborn

care with suspected infection: EN-BIRTH multi-country validation study. BMC Pregnancy and Childbirth.

2021;21(Suppl 1):229.

3. Wiens MO, Kumbakumba E, Kissoon N, Ansermino JM, Ndamira A, Larson CP. Pediatric sepsis in the

developing world: challenges in defining sepsis and issues in post-discharge mortality. Clin

Epidemiol. 2012;4:319–25.

4. Macnow T, O’Toole D, DeLaMora P, Murray M, Rivera K, Whittier S, et al. Utility of Surveillance

Cultures for Antimicrobial Resistant Organisms in Infants Transferred to the Neonatal Intensive Care Unit.

Pediatr Infect Dis J. 2013;32(12):e443–50.

5. Benitz WE, Han MY, Madan A, Ramachandra P. Serial Serum C-Reactive Protein Levels in the Diagnosis

of Neonatal Infection. Pediatrics. 1998;102(4):E41.

6. Hofer N, Zacharias E, Müller W, Resch B. An Update on the Use of C-Reactive Protein in Early-Onset

Neonatal Sepsis: Current Insights and New Tasks. Neonatology. 2012;102(1):25–36.

7. Macallister K, Smith-Collins A, Gillet H, Hamilton L, Davis J. Serial C-Reactive Protein Measurements in

Newborn Infants without Evidence of Early-Onset Infection. Neonatology. 2019;116(1):85–91.

8. Tessema B, Lippmann N, Willenberg A, Knüpfer M, Sack U, König B. The Diagnostic Performance of

Interleukin-6 and C-Reactive Protein for Early Identification of Neonatal Sepsis. Diagnostics.

2020;10(11):978.

9. Björnsdóttir ES, Martins ER, Erlendsdóttir H, Haraldsson G, Melo-Cristino J, Ramirez M, et al. Group B

Streptococcal Neonatal and Early Infancy Infections in Iceland, 1976–2015. Pediatr Infect Dis J.

2019;38(6):620–4.

10. Perrone S, Lotti F, Longini M, Rossetti A, Bindi I, Bazzini F, et al. C reactive protein in healthy term

newborns during the first 48 hours of life. Arch Dis Child Fetal Neonatal Ed. 2018;103(2):F163–6.

11. Rallis D, Balomenou F, Kappatou K, Karantanou K, Tzoufi M, Giapros V. C-reactive protein in infants with

no evidence of early-onset sepsis. J Matern Fetal Neonatal Med. 2021;17:1–8.

12. Lacaze-Masmonteil T, Rosychuk RJ, Robinson JL. Value of a single C-reactive protein measurement at 18

E84

NEWBORN INFECTION MANAGEMENT AT A REGIONAL HOSPITAL

h of age. Arch Dis Child Fetal Neonatal Ed. 2014;99(1):F76–9.

13. Chen Y, Yin Z, Gong X, Li J, Zhong W, Shan L, et al. A sequential guide to identify neonates with low

bacterial meningitis risk: a multicenter study. Ann Clin Transl Neurol. 2021;8(5):1132–40.

14. Friedman N, Yochpaz S, Zirkin S, Herzlich J, Marom R. C-reactive protein and the neonatal early-onset

sepsis calculator for the diagnosis of neonatal sepsis. Eur J Clin Microbiol Infect Dis. 2021;40(6):1227–34.

15. van der Hoeven A, van der Beek MT, Lopriore E, Steggerda SJ, Bekker V. Predicting Neonatal Early Onset

Sepsis: A 14-year Cohort Study. Pediatr Infect Dis J. 2022;41(1):72–77.

16. Mishra UK, Jacobs SE, Doyle LW, Garland SM. Newer approaches to the diagnosis of early onset neonatal

sepsis. Arch Dis Child Fetal Neonatal Ed. 2006;91(3):F208–12.

17. Kasap B, Duman N, Özer E, Tatli M, Kumral A, Özkan H. Transient tachypnea of the newborn: Predictive

factor for prolonged tachypnea. Pediatr Int. 2008;50(1):81–4.

18. Li J, Wu J, Du L, Hu Y, Yang X, Mu D, et al. Different antibiotic strategies in transient tachypnea of the

newborn: an ambispective cohort study. Eur J Pediatr. 2015;174(9):1217–23.

E85

...

参考文献をもっと見る

全国の大学の
卒論・修論・学位論文

一発検索!

この論文の関連論文を見る