リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

大学・研究所にある論文を検索できる 「Acetaminophen improves tardive akathisia induced by dopamine D₂ receptor antagonists」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

コピーが完了しました

URLをコピーしました

論文の公開元へ論文の公開元へ
書き出し

Acetaminophen improves tardive akathisia induced by dopamine D₂ receptor antagonists

Nagaoka, Koki Nagayasu, Kazuki Shirakawa, Hisashi Kaneko, Shuji 京都大学 DOI:10.1016/j.jphs.2022.10.006

2023.01

概要

Tardive akathisia is a movement disorder characterized by internal restlessness with an uncontrollable urge to move, leading to repetitive movements. It is a common side effect of long-term treatment with dopamine D₂ receptor antagonists. In the present study, we analyzed the FDA Adverse Event Reporting System and IBM MarketScan Research Database to find a drug that can be used concomitantly with dopamine D₂ receptor antagonists and still reduce the risk of akathisia. Acetaminophen was determined to be the most effective akathisia-suppressing drug. In an experimental validation of the hypothesis, chronic treatment of rats with haloperidol caused akathisia symptoms, including increased stereotyped behavior and locomotor activity, and decreased immobility time. Acute treatment with acetaminophen significantly attenuated haloperidol-induced akathisia. In the ventral striata of these rats, acetaminophen prevented haloperidol-induced decrease in the number of c-Fos⁺ preproenkephalin⁺ neurons. These results suggest that acetaminophen is effective in suppressing tardive akathisia by activating indirect-pathway medium spiny neurons.

この論文で使われている画像

参考文献

1. Barnes TR. The Barnes akathisia rating scale–revisited. J Psychopharmacol.

2003;17(4):365e370.

2. Van Putten T. The many faces of akathisia. Compr Psychiatr. 1975;16(1):43e47.

3. Salem H, Nagpal C, Pigott T, Teixeira AL. Revisiting antipsychotic-induced

akathisia: current issues and prospective challenges. Curr Neuropharmacol.

2017;15(5):789e798.

4. Lohr JB, Eidt CA, Abdulrazzaq Alfaraj A, Soliman MA. The clinical challenges of

akathisia. CNS Spectr. 2015;20(Suppl 1):1e14. quiz 15e16.

5. Burke RE, Kang UJ, Jankovic J, Miller LG, Fahn S. Tardive akathisia: an analysis of

clinical features and response to open therapeutic trials. Mov Disord. 1989;4(2):

157e175.

6. Savitt D, Jankovic J. Tardive syndromes. J Neurol Sci. 2018;389:35e42.

7. Nagaoka K, Nagashima T, Asaoka N, et al. Striatal TRPV1 activation by acetaminophen ameliorates dopamine D2 receptor antagonist-induced orofacial

dyskinesia. JCI Insight. 2021;6(10), e145632.

8. Banda JM, Evans L, Vanguri RS, Tatonetti NP, Ryan PB, Shah NH. A curated and

standardized adverse drug event resource to accelerate drug safety research.

Sci Data. 2016;3, 160026.

9. Nagashima T, Shirakawa H, Nakagawa T, Kaneko S. Prevention of

antipsychotic-induced hyperglycaemia by vitamin D: a data mining prediction followed by experimental exploration of the molecular mechanism. Sci

Rep. 2016;6, 26375.

10. Lai EC, Pratt N, Hsieh CY, et al. Sequence symmetry analysis in pharmacovigilance and pharmacoepidemiologic studies. Eur J Epidemiol. 2017;32(7):

567e582.

11. Olmos A, Govindasamy P. Propensity scores: a practical introduction using R.

J Multidiscrip Eval. 2015;11(25):68e88.

12. Austin PC. Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational

studies. Pharmaceut Stat. 2011;10(2):150e161.

Author contributions

Ko.N. performed clinical data analysis and animal experiments.

Ka.N. and H.S. provided materials and technical advice. Ko.N. and S.K.

designed the project, analyzed the data, and wrote the manuscript.

15

K. Nagaoka, K. Nagayasu, H. Shirakawa et al.

Journal of Pharmacological Sciences 151 (2023) 9e16

23. Zhang JP, Gallego JA, Robinson DG, Malhotra AK, Kane JM, Correll CU. Efficacy

and safety of individual second-generation vs. first-generation antipsychotics

in first-episode psychosis: a systematic review and meta-analysis. Int J Neuropsychopharmacol. 2013;16(6):1205e1218.

24. Walters A, Hening W, Chokroverty S, Fahn S. Opioid responsiveness in patients

with neuroleptic-induced akathisia. Mov Disord. 1986;1(2):119e127.

25. Lublin H, Gerlach J, Mørkeberg F. Long-term treatment with low doses of

the D1 antagonist NNC 756 and the D2 antagonist raclopride in monkeys

previously exposed to dopamine antagonists. Psychopharmacology.

1994;114(3):495e504.

26. Iyo M, Tadokoro S, Kanahara N, et al. Optimal extent of dopamine D2 receptor

occupancy by antipsychotics for treatment of dopamine supersensitivity psychosis and late-onset psychosis. J Clin Psychopharmacol. 2013;33(3):398e404.

27. Bordia T, Zhang D, Perez XA, Quik M. Striatal cholinergic interneurons and D2

receptor-expressing GABAergic medium spiny neurons regulate tardive

dyskinesia. Exp Neurol. 2016;286:32e39.

28. Tadokoro S, Okamura N, Sekine Y, Kanahara N, Hashimoto K, Iyo M. Chronic

treatment with aripiprazole prevents development of dopamine supersensitivity and potentially supersensitivity psychosis. Schizophr Bull. 2012;38(5):

1012e1020.

29. Oda Y, Fujita Y, Oishi K, et al. Alterations in glutamatergic signaling in the brain

of dopamine supersensitivity psychosis and non-supersensitivity psychosis

model rats. Psychopharmacology. 2017;234(20):3027e3036.

 ski J. Paracetamol - an old drug with new

30. Przybyła GW, Szychowski KA, Gmin

mechanisms of action. Clin Exp Pharmacol Physiol. 2020;48(1):3e19.

rez J, et al. Hyperactivity induced by the

31. Luque-Rojas MJ, Galeano P, Sua

dopamine D2/D3 receptor agonist quinpirole is attenuated by inhibitors of

endocannabinoid degradation in mice. Int J Neuropsychopharmacol. 2013;16(3):

661e676.

13. Thomsen M, Fink-Jensen A, Woldbye DPD, et al. Effects of acute and chronic

aripiprazole treatment on choice between cocaine self-administration and food

under a concurrent schedule of reinforcement in rats. Psychopharmacology.

2008;201(1):43e53.

14. Oda Y, Tadokoro S, Takase M, et al. G protein-coupled receptor kinase 6/barrestin 2 system in a rat model of dopamine supersensitivity psychosis.

J Psychopharmacol. 2015;29(12):1308e1313.

15. Fleischhacker WW, Bergmann KJ, Perovich R, et al. The Hillside Akathisia Scale:

a new rating instrument for neuroleptic-induced akathisia. Psychopharmacol

Bull. 1989;25(2):222e226.

16. Bleickardt CJ, Kazdoba TM, Jones NT, Hunter JC, Hodgson RA. Antagonism of the

adenosine A2A receptor attenuates akathisia-like behavior induced with MP10 or aripiprazole in a novel non-human primate model. Pharmacol Biochem

Behav. 2014;118:36e45.

17. Ehrenpreis ED, Deepak P, Sifuentes H, Devi R, Du H, Leikin JB. The metoclopramide black box warning for tardive dyskinesia: effect on clinical practice,

adverse event reporting, and prescription drug lawsuits. Am J Gastroenterol.

2013;108(6):866e872.

18. Sieminski M, Zemojtel L. Akathisia is more than restlessness in the legs. J Clin

Sleep Med. 2019;15(9):1383.

19. Lyu S, Xing H, DeAndrade MP, et al. The role of BTBD9 in striatum and restless

legs syndrome. eNeuro. 2019;6(5), 0277-19.2019.

20. Qu S, Le W, Zhang X, Xie W, Zhang A, Ondo WG. Locomotion is increased in

a11-lesioned mice with iron deprivation: a possible animal model for restless

legs syndrome. J Neuropathol Exp Neurol. 2007;66(5):383e388.

21. Stahl SM, Lonnen AJ. The Mechanism of drug-induced akathsia. CNS Spectr.

2011;15. Stahl.

22. Mulroy E, Balint B, Bhatia KP. Tardive syndromes. Practical Neurol. 2020;20(5):

368e376.

16

...

参考文献をもっと見る

全国の大学の
卒論・修論・学位論文

一発検索!

この論文の関連論文を見る