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Figure legends

Fig. 1. Examples of compounds having gravitropic inhibitory activity.

Fig. 2. Lead compound, ku-76

Fig. 3. Evaluation method for inhibitory activity against root gravitropic bending. Gravity

vectors before (g1) and after (g2) reorientation are indicated. The length (l, cm) of the

root length and the angle ( degree) of the curvature after reorientation were measured.

The figure represents the lettuce seeding (mock treated).

Fig. 4 Inhibition tests of gravitropic bending at various concentrations of ku-76 ((a)

control, (b) [ku-76]; A: 10 M, B: 5 M, C: 1 M), (c) Effect of ku-76 on gravitropism,

(d) elongation. Data represent mean ± SD. Asterisk indicates statistically significant

differences between treatments and control at p < 0.05 (Welch t-test, n = 7).

Fig. 5. Three functional units for SAR study of ku-76.

Fig. 6. Structures of the analogues of ku-76.

Fig. 7. Inhibitory activity tests of gravitropic bending and elongation for skeletal

analogues (50 M except for ku-76 (10 M). Data for (A) gravitropic bending and (B)

elongation represent mean ± SD. Asterisk indicates statistically significant differences

between treatments and control at p < 0.05 (Welch t-test, n = 7)

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Fig. 8. Inhibitory activity tests for amide, alcohol, ester analogues (50 M). Data of (A)

gravitropic bending and (B) elongation represent mean ± SD. Asterisk indicates

statistically significant differences between treatments and control at p < 0.05 (Welch ttest, n = 7)

Fig. 9. Essential structural features of ku-76 in root gravitropic bending tests.

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Fig. 1

Fig. 2

Fig. 3

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Fig. 4

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Fig. 5

Fig 6

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Fig 7

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Fig 8

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Fig 9

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