リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

大学・研究所にある論文を検索できる 「Dengue Fever Complicated with Hemophagocytic Lymphohistiocytosis: A Case Report of Resolution with Steroid-Sparing Supportive Care」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

コピーが完了しました

URLをコピーしました

論文の公開元へ論文の公開元へ
書き出し

Dengue Fever Complicated with Hemophagocytic Lymphohistiocytosis: A Case Report of Resolution with Steroid-Sparing Supportive Care

Mizutani, Naoya Kenzaka, Tsuneaki Nishisaki, Hogara 神戸大学

2023.11

概要

Dengue fever (DF) can be complicated by hemophagocytic lymphohistiocytosis (HLH). Steroid administration is markedly effective for this hematologic complication, and for other viral infections. We present a rare case of DF-associated HLH that improved with steroid-sparing supportive care. A 47-year-old Japanese male with diabetes mellitus and no history of DF traveled to the Philippines 10 days before his hospitalization. Three days before emergency admission, he experienced fever and joint pain and was referred to our hospital for suspected DF, after blood tests indicated liver damage and thrombocytopenia. Erythema of the extremities and trunk appeared on day 2, and the next day neutrophils were 550 cells/μL, platelets 29,000 cells/μL, ferritin 9840 ng/mL, and fibrinogen 141 mg/dL. Bone marrow aspirate revealed hemophagocytic lymphohistiocytosis, and he was diagnosed with HLH. On day 4, the symptoms and findings improved; only supportive care without steroids was continued. He tested positive for dengue virus antigen on admission. He was discharged on day 9 of hospitalization in good general condition with no vascular leakage or bleeding and recovery of blood cells. Although steroid administration is markedly effective in cases of DF complicated by HLH, this case suggests that such cases can resolve with steroid-sparing supportive care.

この論文で使われている画像

参考文献

1.

2.

3.

4.

5.

6.

7.

8.

9.

10.

11.

12.

13.

14.

15.

Simmons, C.P.; Farrar, J.J.; Nguyen, v.V.; Wills, B. Dengue. N. Engl. J. Med. 2012, 366, 1423–1432. [CrossRef] [PubMed]

Dengue: Guidelines for Diagnosis, Treatment. Available online: https://pubmed.ncbi.nlm.nih.gov/23762963/ (accessed on 1

September 2023).

La Russa, V.F.; Innis, B.L. Mechanisms of dengue virus-induced bone marrow suppression. Bailliere’s Clin. Haematol. 1995, 8,

249–270. [CrossRef] [PubMed]

Saito, M.; Oishi, K.; Inoue, S.; Dimaano, E.M.; Alera, M.T.; Robles, A.M.; Estrella, B.D., Jr.; Kumatori, A.; Moji, K.; Alonzo,

M.T.; et al. Association of increased platelet-associated immunoglobulins with thrombocytopenia and the severity of disease in

secondary dengue virus infections. Clin. Exp. Immunol. 2004, 138, 299–303. [CrossRef] [PubMed]

Roy, M.; Bandyopadhyay, D.; Saha, K.; Sarkar, S.; Ranjit, P.; Thiyagarajan, G.; Mondal, R.S.; Naskar, S.; Patra, S. Hemophagocytosis

in dengue. Assam J. Intern. Med. 2013, 3, 27–29.

Wan Jamaludin, W.F.; Periyasamy, P.; Wan Mat, W.R.; Abdul Wahid, S.F. Dengue infection associated hemophagocytic syndrome:

Therapeutic interventions and outcome. J. Clin. Virol. 2015, 69, 91–95. [CrossRef]

Chung, S.M.; Song, J.Y.; Kim, W.; Choi, M.J.; Jeon, J.H.; Kang, S.; Jung, E.; Noh, J.Y.; Cheong, H.J.; Kim, W.J. Dengue-associated

hemophagocytic lymphohistiocytosis in an adult: A case report and literature review. Medicine 2017, 96, e6159. [CrossRef]

[PubMed]

Henter, J.I.; Horne, A.; Aricó, M.; Egeler, R.M.; Filipovich, A.H.; Imashuku, S.; Ladisch, S.; McClain, K.; Webb, D.; Winiarski, J.;

et al. HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr. Blood Cancer 2007, 48,

124–131. [CrossRef]

Fardet, L.; Galicier, L.; Lambotte, O.; Marzac, C.; Aumont, C.; Chahwan, D.; Coppo, P.; Hejblum, G. Development and validation

of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome. Arthritis Rheumatol. 2014, 66, 2613–2620. [CrossRef]

Imashuku, S.; Ueda, I.; Teramura, T.; Mori, K.; Morimoto, A.; Sako, M.; Ishii, E. Occurrence of haemophagocytic lymphohistiocytosis at less than 1 year of age: Analysis of 96 patients. Eur. J. Pediatr. 2005, 164, 315–319. [CrossRef]

Russell, J.H.; Ley, T.J. Lymphocyte-mediated cytotoxicity. Annu. Rev. Immunol. 2002, 20, 323–370. [CrossRef]

Risma, K.A.; Frayer, R.W.; Filipovich, A.H.; Sumegi, J. Aberrant maturation of mutant perforin underlies the clinical diversity of

hemophagocytic lymphohistiocytosis. J. Clin. Investig. 2006, 116, 182–192. [CrossRef] [PubMed]

Jordan, M.B.; Hildeman, D.; Kappler, J.; Marrack, P. An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T

cells and interferon gamma are essential for the disorder. Blood 2004, 104, 735–743. [CrossRef]

Janka, G.E.; Schneider, E.M. Modern management of children with haemophagocytic lymphohistiocytosis. Br. J. Haematol. 2004,

124, 4–14. [CrossRef] [PubMed]

Arnaout, R.A. Perforin deficiency: Fighting unarmed? Immunol. Today 2000, 21, 592. [CrossRef] [PubMed]

Trop. Med. Infect. Dis. 2023, 8, 497

16.

17.

18.

19.

20.

21.

22.

23.

24.

25.

26.

27.

28.

29.

30.

31.

32.

33.

34.

35.

9 of 9

Moretta, L.; Moretta, A.; Hengartner, H.; Zinkernagel, R.M. On the pathogenesis of perforin defects and related immunodeficiencies. Immunol. Today 2000, 21, 593–594. [CrossRef] [PubMed]

Katano, H.; Cohen, J.I. Perforin and lymphohistiocytic proliferative disorders. Br. J. Haematol. 2005, 128, 739–750. [CrossRef]

[PubMed]

Homchampa, P.; Sarasombath, S.; Suvatte, V.; Vongskul, M. Natural killer cells in dengue hemorrhagic fever/dengue shock

syndrome. Asian Pac. J. Allergy Immunol. 1988, 6, 95–102.

Matangkasombut, P.; Chan-In, W.; Opasawaschai, A.; Pongchaikul, P.; Tangthawornchaikul, N.; Vasanawathana, S.; Limpitikul,

W.; Malasit, P.; Duangchinda, T.; Screaton, G.; et al. Invariant NKT cell response to dengue virus infection in human. PLOS Negl.

Trop. Dis. 2014, 8, e2955. [CrossRef]

Sun, W.; Wang, Y.; East, J.E.; Kimball, A.S.; Tkaczuk, K.; Kesmodel, S.; Strome, S.E.; Webb, T.J. Invariant natural killer T cells

generated from human adult hematopoietic stem-progenitor cells are poly-functional. Cytokine 2015, 72, 48–57. [CrossRef]

Ramanathan, M.; Duraisamy, G. Haemophagocytosis in dengue haemorrhagic fever: A case report. Ann. Acad. Med. Singap. 1991,

20, 803–804.

Wong, K.F.; Chan, J.K.; Chan, J.C.; Lim, W.W.; Wong, W.K. Dengue virus infection-associated hemophagocytic syndrome. Am. J.

Hematol. 1991, 38, 339–340. [CrossRef] [PubMed]

Lu, P.L.; Hsiao, H.H.; Tsai, J.J.; Chen, T.C.; Feng, M.C.; Chen, T.P.; Lin, S.F. Dengue virus-associated hemophagocytic syndrome

and dyserythropoiesis: A case report. Kaohsiung J. Med. Sci. 2005, 21, 34–39. [CrossRef]

Srichaikul, T.; Punyagupta, S.; Kanchanapoom, T.; Chanokovat, C.; Likittanasombat, K.; Leelasiri, A. Hemophagocytic synrome in

dengue hemorrhagic fever with severe multiorgan complications. J. Med. Assoc. Thai. 2008, 91, 104–109. [PubMed]

Nakamura, I.; Nakamura-Uchiyama, F.; Komiya, N.; Ohnishi, K. A case of dengue fever with viral-associated hemophagocytic

syndrome. Kansenshogaku Zasshi 2009, 83, 60–63. (In Japanese) [CrossRef]

Ray, S.; Kundu, S.; Saha, M.; Chakrabarti, P. Hemophagocytic syndrome in classic dengue fever. J. Glob. Infect. Dis. 2011, 3,

399–401. [CrossRef]

Sorakhunpipitkul, L.; Punyagupta, S.; Srichaikul, T.; Tribuddharat, S. Thai adult dengue hemorrhagic fever during 2008–2010:

Seven cases presented with severe multiorgan failure and successfully treated with high dose of corticosteroids and intravenous

immunoglobulin G. J. Infect. Dis. Antimicrob. Agents 2011, 28, 99–103.

Tan, L.H.; Lum, L.C.; Omar, S.F.; Kan, F.K. Hemophagocytosis in dengue: Comprehensive report of six cases. J. Clin. Virol. 2012,

55, 79–82. [CrossRef]

Ribeiro, E.; Kassab, S.; Pistone, T.; Receveur, M.C.; Fialon, P.; Malvy, D. Primary dengue fever associated with hemophagocytic

syndrome: A report of three imported cases, Bordeaux, France. Intern. Med. 2014, 53, 899–902. [CrossRef]

De Koninck, A.S.; Dierick, J.; Steyaert, S.; Taelman, P. Hemophagocytic lymphohistiocytosis and dengue infection: Rare case

report. Acta Clin. Belg. 2014, 69, 210–213. [CrossRef]

Sharp, T.M.; Gaul, L.; Muehlenbachs, A.; Hunsperger, E.; Bhatnagar, J.; Lueptow, R.; Santiago, G.A.; Muñoz-Jordan, J.L.; Blau,

D.M.; Ettestad, P.; et al. Fatal hemophagocytic lymphohistiocytosis associated with locally acquired dengue virus infection—New

Mexico and Texas, 2012. MMWR Morb. Mortal. Wkly. Rep. 2014, 63, 49–54.

Arshad, U.; Ahmad, S.Q.; Khan, F. Hemophagocytic lymphohistiocytosis in a patient with dengue infection. Hematol. Oncol. Stem

Cell Ther. 2015, 8, 189–190. [CrossRef] [PubMed]

Yoshifuji, K.; Oshina, T.; Sonokawa, S.; Noguchi, Y.; Suzuki, S.; Tanaka, K.; Kumagai, T. Domestic dengue infection with

hemophagocytic lymphohistiocytosis successfully treated by early steroid therapy. Rinsho Ketsueki 2016, 57, 864–868. (In Japanese)

[CrossRef]

Jasmine, Y.S.; Lee, S.L.; Kan, F.K. Infection associated haemophagocytic syndrome in severe dengue infection—A case series in a

district hospital. Med. J. Malaysia 2017, 72, 62–64. [PubMed]

Anam, A.M.; Rabbani, R.; Shumy, F. Expanded dengue syndrome: Three concomitant uncommon presentations in the same

patient. Trop. Dr. 2017, 47, 167–170. [CrossRef] [PubMed]

Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual

author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to

people or property resulting from any ideas, methods, instructions or products referred to in the content.

...

参考文献をもっと見る

全国の大学の
卒論・修論・学位論文

一発検索!

この論文の関連論文を見る