関連論文
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Human iPSC-derived renal collecting duct organoid model cystogenesis in ADPKD
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In vivo regeneration of interspecies chimeric kidneys using a nephron progenitor cell replacement system
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iPSC-derived type IV collagen α5-expressing kidney organoids model Alport syndrome
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STAT3 induces hypoxic preconditioning against oxidative stress in neural stem cells
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Immunosuppressants Tacrolimus and Sirolimus revert the cardiac antifibrotic properties of p38-MAPK inhibition in 3D-multicellular human iPSC-heart organoids
参考文献
1. GBD Chronic Kidney Disease Collaboration. Global, regional,
and national burden of chronic kidney disease, 1990–2017:
a systematic analysis for the Global Burden of Disease
Study 2017. Lancet. 2020;395(10225):709–33. https: //doi.
org/10.1016/S0140-6736(20)30045-3.
2. Karagiannis P, Takahashi K, Saito M, Yoshida Y, Okita K,
Watanabe A, Inoue H, Yamashita JK, Todani M, Nakagawa
M, Osawa M, Yashiro Y, Yamanaka S, Osafune K. Induced
pluripotent stem cells and their use in human models of disease
and development. Physiol Rev. 2019;99(1):79–114. https://doi.
org/10.1152/physrev.00039.2017.
3. Saxen L. Organogenesis of the kidney. Cambridge: Cambridge
University Press; 1987.
4. Osafune K, Takasato M, Kispert A, Asashima M, Nishinakamura R. Identification of multipotent progenitors in the embryonic mouse kidney by a novel colony-forming assay. Development. 2006;133(1):151–61. https://doi.org/10.1242/dev.02174.
5. Kobayashi A, Valerius MT, Mugford JW, Carroll TJ, Self
M, Oliver G, McMahon AP. Six2 defines and regulates a
multipotent self-renewing nephron progenitor population
throughout mammalian kidney development. Cell Stem Cell.
2008;3(2):169–81. https://doi.org/10.1016/j.stem.2008.05.020.
6. Taguchi A, Kaku Y, Ohmori T, Sharmin S, Ogawa M, Sasaki H,
Nishinakamura R. Redefining the in vivo origin of metanephric
nephron progenitors enables generation of complex kidney structures from pluripotent stem cells. Cell Stem Cell.
2014;14(1):53–67. https://doi.org/10.1016/j.stem.2013.11.010.
7. Mugford JW, Sipilä P, McMahon JA, McMahon AP. Osr1
expression demarcates a multi-potent population of intermediate mesoderm that undergoes progressive restriction to an
Osr1-dependent nephron progenitor compartment within the
mammalian kidney. Dev Biol. 2008;324(1):88–98. https://doi.
org/10.1016/j.ydbio.2008.09.010.
8. Mae S, Shono A, Shiota F, Yasuno T, Kajiwara M, GotodaNishimura N, Arai S, Sato-Otubo A, Toyoda T, Takahashi K,
Nakayama N, Cowan CA, Aoi T, Ogawa S, McMahon AP,
Yamanaka S, Osafune K. Monitoring and robust induction of
nephrogenic intermediate mesoderm from human pluripotentstemcells. Nat Commun. 2013;4:1367. https://doi.org/10.1038/
ncomms2378.
9. Araoka T, Mae S, Kurose Y, Uesugi M, Ohta A, Yamanaka S,
Osafune K. Efficient and rapid induction of human iPSCs/ESCs
into nephrogenic intermediate mesoderm using small moleculebased differentiation methods. PLoS ONE. 2014;9(1):e84881.
https://doi.org/10.1371/journal.pone.0084881.
10. Takasato M, Er PX, Chiu HS, Maier B, Baillie GJ, Ferguson
C, Parton RG, Wolvetang EJ, Roost MS, de Sousa C, Lopes
SM, Little MH. Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis. Nature.
2015;526(7574):564–8. https://doi.org/10.1038/nature15695.
11. Morizane R, Lam AQ, Freedman BS, Kishi S, Valeius MT, Bonventre JV. Nephron organoids derived from human pluripotent
stem cells model kidney development and injury. Nat Biotechnol.
2015;33(11):1193–200. https://doi.org/10.1038/nbt.3392.
583
12. Tsujimoto H, Kasahara T, Sueta S, Araoka T, Sakamoto S, Okada
C, Mae SI, Nakajima T, Okamoto N, Taura D, Nasu M, Shimizu
T, Ryosaka M, Li Z, Sone M, Ikeya M, Watanabe A, Osafune K.
A modular differentiation system maps multiple human kidney
lineage from pluripotent stem cells. Cell Rep. 2020;31(1):107476.
https://doi.org/10.1016/j.celrep.2020.03.040.
13. Taguchi A, Nishinakamura R. Higher-order kidney organogenesis
from pluripotent stem cells. Cell Stem Cell. 2017;21(6):730-46.
e6. https://doi.org/10.1016/j.stem.2017.10.011.
14. Mae SI, Ryosaka M, Toyoda T, Matsuse K, Oshima Y, Tsujimoto
H, Okumura S, Shibasaki A, Osafune K. Generation of branching ureteric bud tissues from human pluripotent stem cells. Biochem Biophys Res Commun. 2018;495(1):954–61. https://doi.
org/10.1016/j.bbrc.2017.11.105.
15. Mae SI, Ryosaka M, Sakamoto S, Matsuse K, Nozaki A, Igami
M, Kabai R, Watanabe A, Osafune K. Expansion of human iPSCderived ureteric bud organoids with repeated branching potential. Cell Rep. 2020;32(4):107963. https://doi.org/10.1016/j.celre
p.2020.107963.
16. Brown AC, Muthukrishnan SD, Oxburgh L. A synthetic niche for
nephron progenitor cells. Dev Cell. 2015;34(2):229–41. https://
doi.org/10.1016/j.devcel.2015.06.021.
17. Tanigawa S, Taguchi A, Sharma N, Perantoni AO, Nishinakamura R. Selective in vitro propagation of nephron progenitors
derived from embryos and pluripotent stem cells. Cell Rep.
2016;15(4):801–13. https: //doi.org/10.1016/j.celrep .2016.03.076.
18. Li Z, Araoka T, Wu J, Liao H, Li M, Lazo M, Zhou B, Sui Y, Wu
MZ, Tamura I, Xia Y, Beyret E, Matsusaka T, Pastan I, Rodriguez
Esteban C, Guillen I, Guillen P, Campistol JM, Izpisua Belmonte
JC. 3D culture supports long-term expansion of mouse and human
nephrogenic progenitors. Cell Stem Cell. 2016;19(4):516–29.
https://doi.org/10.1016/j.stem.2016.07.016.
19. Tsujimoto H, Araoka T, Nishi Y, Ohta A, Nakahata T, Osafune
K. Small molecule TCS21311 can replace BMP7 and facilitate
cell proliferation in in vitro expansion culture of nephron progenitor cells. Biochem Biophys Res Commun. 2020. https://doi.
org/10.1016/j.bbrc.2020.02.130 (in press).
20. Moriya N, Uchiyama H, Asashima M. Induction of pronephric
tubules by activin and retinoic acid in presumptive ectoderm of
Xenopus laevis. Dev Growth Differ. 1993;35:123–8.
21. Brennan HC, Nijjar S, Jones EA. The specification and growth
factor inducibility of the pronephric glomus in Xenopus laevis.
Development. 1999;126(24):5847–56.
22. Osafune K, Nishinakamura R, Komazaki S, Asashima M. In vitro
induction of the pronephric duct in Xenopus explants. Dev
Growth Differ. 2002;44(2):161–7. https: //doi.org/10.1046/j.1440169x.2002.00631.x.
23. Goto T, Hara H, Sanbo M, Masaki H, Sato H, Yamaguchi T, Hochi
S, Kobayashi T, Nakauchi H, Hirabayashi M. Generation of pluripotent stem cell-derived mouse kidney in Sall1-targeted anephric
rats. Nat Commun. 2019;10(1):451. https: //doi.org/10.1038/s4146
7-019-08394-9.
24. Fujimoto T, Yamanaka S, Tajiri S, Takamura T, Saito Y, Matsumoto N, Matsumoto K, Tachibana T, Okano HJ, Yokoo
T. Generation of human renal vesicles in mouse organ niche
using nephron progenitor cell replacement system. Cell Rep.
2020;32(11):108130. https: //doi.org/10.1016/j.celrep .2020.10813
0.
25. Freedman BS, Lam AQ, Sundsbak JL, Iatrino R, Su X, Koon SJ,
Wu M, Daheron L, Harris PC, Zhou J, Bonventre JV. Reduced ciliary polycystin-2 in induced pluripotent stem cells from polycystic
kidney disease patients with PKD1 mutations. J Am Soc Nephrol.
2013;24(10):1571–86. https://doi.org/10.1681/ASN.2012111089
26. Ameku T, Taura D, Sone M, Numata T, Nakamura M, Shiota F,
Toyoda T, Matsui S, Araoka T, Yasuno T, Mae SI, Kobayashi H,
13
A Self-archived copy in
Kyoto University Research Information Repository
https://repository.kulib.kyoto-u.ac.jp
584
27. 28. 29. 30. Clinical and Experimental Nephrology (2021) 25:574–584
Kondo N, Kitaoka F, Amano N, Arai S, Ichisaka T, Matsuura N,
Inoue S, Yamamoto T, Takahashi K, Asaka I, Yamada Y, Ubara
Y, Muso E, Fukatsu A, Watanabe A, Sato Y, Nakahata T, Mori
Y, Koizumi A, Nakao K, Yamanaka S, Osafune K. Identification of MMP1 as a novel risk factor for intracranial aneurysms in
ADPKD using iPSC models. Sci Rep. 2015;6:30013. https://doi.
org/10.1038/srep30013.
Forbes TA, Howden SE, Lawlor K, Phipson B, Maksimovic J,
Hale L, Wilson S, Quinlan C, Ho G, Holman K, Bennetts B, Crawford J, Trnka P, Oshlack A, Patel C, Mallett A, Simons C, Little
MH. Patient-iPSC-derived kidney organoids show functional
validation of a ciliopathic renal phenotype and reveal underlying
pathogenetic mechanisms. Am J Hum Genet. 2018;102(5):816–
31. https://doi.org/10.1016/j.ajhg.2018.03.014.
Tanigawa S, Islam M, Sharmin S, Naganuma H, Yoshimura Y,
Haque F, Era T, Nakazato H, Nakanishi K, Sakuma T, Yamamoto
T, Kurihara H, Taguchi A, Nishinakamura R. Organoids from
nephrotic disease-derived iPSCs identify impaired NEPHRIN
localization and slit diaphragm formation in kidney podocytes.
Stem Cell Reports. 2018;11(3):727–40. https://doi.org/10.1016/j.
stemcr.2018.08.003.
Low JH, Li P, Chew EGY, Zhou B, Suzuki K, Zhang T, Lian
MM, Liu M, Aizawa E, Rodriguez Esteban C, Yong KSM, Chen
Q, Campistol JM, Fang M, Khor CC, Foo JN, Izpisua Belmonte
JC, Xia Y. Generation of human PSC-derived kidney organoids
with patterned nephron segments and a de novo vascular network.
Cell Stem Cell. 2019;25(3):373–879. https://doi.org/10.1016/j.
stem.2019.06.009.
Czerniecki SM, Cruz NM, Harder JL, Menon R, Annis J, Otto EA,
Gulieva RE, Islas LV, Kim YK, Tran LM, Martins TJ, Pippin JW,
Fu H, Kretzler M, Shankland SJ, Himmelfarb J, Moon RT, Paragas N, Freedman BS. High-throughput screening enhances kidney
organoid differentiation from human pluripotent stem cells and
13
31. 32. 33. 34. 35. enables automated multidimensional phenotyping. Cell Stem Cell.
2018;22(6):929–40. https://doi.org/10.1016/j.stem.2018.04.022.
Shimizu T, Mae SI, Araoka T, Okita K, Hotta A, Yamagata K,
Osafune K. A novel ADPKD model using kidney organoids
derived from disease-specific human iPSCs. Biochem Biophys
Res Commun. 2020;12:34–43.
Hitomi H, Kasahara T, Katagiri N, Hoshina A, Mae SI, Kotaka M,
Toyohara T, Rahman A, Nakano D, Niwa A, Saito MK, Nakahata
T, Nishiyama A, Osafune K. Human pluripotent stem cell-derived
erythropoietin-producing cells ameliorate renal anemia in mice.
Sci Transl Med. 2017;9(409):eaaj2300. https://doi.org/10.1126/
scitranslmed.aaj2300.
Toyohara T, Mae SI, Sueta SI, Inoue T, Yamagishi Y, Kawamoto
T, Kasahara T, Hoshina A, Toyoda T, Tanaka H, Araoka T, SatoOtsubo A, Takahashi K, Sato Y, Yamaji N, Ogawa S, Yamanaka
S, Osafune K. Cell therapy using human induced pluripotent stem
cell-derived renal progenitors ameliorates acute kidney injury in
mice. Stem Cells Transl Med. 2015;4(9):980–92. https://doi.
org/10.5966/sctm.2014-0219.
Hoshina A, Kawamoto T, Sueta SI, Mae SI, Araoka T, Tanaka H,
Sato Y, Yamagishi Y, Osafune K. Development of new method to
enrich human iPSC-derived renal progenitors using cell surface
markers. Sci Rep. 2018;8(1):6375. https://doi.org/10.1038/s4159
8-018-24714-3.
Imberti B, Tomasoni S, Ciampi O, Pezzotta A, Derosas M, Xinaris
C, Rizzo P, Papadimou E, Novelli R, Benigni A, Remuzzi G,
Morigi M. Renal progenitors derived from human iPSCs engraft
and restore function in a mouse model of acute kidney injury. Sci
Rep. 2015;5:8826. https://doi.org/10.1038/srep08826.
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