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(Received for publication June 5, 2020)

（特に重要な文献については，番号をゴシック体で表記している．）

ミトコンドリアの新奇な機能

85

Research on the Mitochondrial Zone Responsible

for Innate Immunity

Mitsuhiro NISHIGORI and Takumi KOSHIBA

Department of Chemistry, Faculty of Science, Fukuoka University

Abstract

A multi-functional organelle, mitochondrion, participates in a wide variety of cellular processes from

energy metabolism to cell death. Current researches on mitochondria in mammals revealed that they

involve in the cellular innate immune response against infectious microorganisms or sterile activators.

The mitochondrion-related innate immune response is accomplished by the activation of two distinct

signaling transduction pathways, that are the retinoic acid-inducible gene I (RIG-I) pathway and the

NLR family pyrin domain-containing 3 (NLRP3) inflammasomes. In both signaling pathways, a

mitochondrial outer membrane adaptor protein, mitochondrial antiviral signaling (MAVS), acts as a

key role in the signal transduction. In this review, we take a view of our current insights regarding the

fundamental phenomena of mitochondrion-related innate immunity, and review the specific roles of

the mitochondrial zone responsible for the immune responses.

Key words：mitochondria, innate immunity, NLRP3 inflammasomes, RIG-I pathway

...