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Infertility treatment for patients having a microdeletion of azoospermic factor (AZF)

Hibi, Hatsuki Sugie, Miho Sonohara, Megumi Fukunaga, Noritaka Asada, Yoshimasa 名古屋大学

2023.05

概要

Male factor infertility accounts for almost half of the cases in a couple desiring a child.
These male factors problems can be ascribed to infection, immunological factors, anatomical
malformations, or environmental insult. Besides these factors, genetic abnormalities can also
cause male infertility. In conjunction with the use of intracytoplasmic sperm injection (ICSI) and
sperm retrieval technique, patients with chromosomal abnormality are now able to conceive.1,2 In
addition, recent studies have shown that spermatozoa can be retrieved from men with azoospermic
factor (AZF) c microdeletion, thus increasing the chances of conception.3,4
Since patients with AZF microdeletion are generally considered as having non-obstructive
azoospermia (NOA), microscopic testicular sperm extraction (micro-TESE) is employed for sperm
extraction surgery. In the present study, we retrospectively evaluated the clinical characteristics,
sperm retrieval rates, and birth rates for patients with Y chromosome microdeletions in our
institute. ...

参考文献

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References End

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...

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