Coincidence of Thyroid Transcription Factor-1 Positive Thymoma and Pulmonary Adenocarcinoma.

1.

Nakamura N, Miyagi E, Murata S, et al. Expression of thyroid transcription factor-1 in

normal and neoplastic lung tissues. Mod Pathol. 2002;15:1058-1067.

2.

Vidarsdottir H, Tran L, Nodin B, et al. Comparison of three different TTF-1 clones in

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resected primary lung cancer and epithelial pulmonary metastases. Am J Clin Pathol.

3.

Engels EA. Epidemiology of thymoma and associated malignancies. J Thorac Oncol.

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2010;5:S260-S265.

Venuta F, Anile M, Diso D, et al. Thymoma and thymic carcinoma. Eur J Cardiothorac

ur

na

4.

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-p

2018;150:533-544.

Surg. 2010;37:13-25.

Yan B, Seng Sc, Peterson F. Thymoma with nuclear expression of thyroid transcription

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5.

factor-1: a potential diagnostic pitfall on core biopsy. Appl Immunohistochem Mol

Morphol. 2011;19:76-81.

6.

Weissferdt A, Hernandez JC, Kalhor N, et al. Spindle cell thymomas: an

immunohistochemical study of 30 cases. Appl Immunohistochem Mol Morphol.

2011;19:329-335.

7.

Scorer PW, Pinkney M, Mclntosh GG. Thyroid Transcription Factor-1 (TTF-1): protein

expression is not exclusive to lung and thyroid tissue. Available at:

https://www.leicabiosystems.com/fileadmin/biosystems/whitepapers/95.10112_rev_a_TT

F-1_whitepaper_EN.pdf. Accessed May 2011.

Pan CC, Chen PC, Chou TY, et al. Expression of calretinin and other mesothelioma-

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na

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-p

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related markers in thymic carcinoma and thymoma. Hum Pathol. 2003;34:1155-1162.

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8.

Figure Legends

Fig. 1. (A, B) Contrasted-enhanced computed tomography (CT) showed a 10 mm nodule in the

upper lobe of the right lung (arrow) and a 30 mm cystic tumor in the mid mediastinum (arrow).

(C, D) The lung tumor shows slight 18F-fluorodeoxyglucose uptake (maximum standardized

uptake volume, 1.93 to 2.84) (arrow), whereas the mediastinal tumor has intense 18Ffluorodeoxyglucose accumulation (maximum standardized uptake volume, 17.9 to 22.9)

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(arrow).

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Fig. 2. (A) Photomicrograph of hematoxylin and eosin-stained section showing that the lung

tumor is papillary predominant, invasive pulmonary adenocarcinoma (×40). (B–D)

Photomicrographs of immunohistochemical stained-sections showing the lung tumor was

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positive for TTF-1 (B), CK7 (C) and Napsin A (D) (×40).

Fig. 3. (A, B) Photomicrograph of hematoxylin and eosin-stained section showing that

siderophages were observed near the lumen of the cystic area (A) and the mediastinal tumor

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consisted of neoplastic cells with highly pleomorphic nuclei and lymphocytes (B) (×100). (C)

The mediastinal tumor cells were TTF-1-positive (×200). (D) The lymphocytes infiltrating the

mediastinal tumor were CD99-positive (×200).

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