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Acknowledgements
We thank Dr. Randy Blakely (Florida Atlantic University) for providing hSERT-pcDNA3. We also thank the
ChemAxon for the free academic license of Instant J Chem. This work was partly supported by Grants-in-Aid
for Scientific Research from JSPS (to K.N. (JP20H04774, JP20K07064), to S.K. (JP18H04616, JP20H00491)),
AMED (to S.K. (JP20ak0101088h0003)), and SENSHIN Medical Research Foundation (to K.N.).
Author contributions
M.S. wrote the code, performed the experiments, and wrote the main manuscript. K.N. initiated the experiments and wrote the manuscript for assay related part. N.S., C.A., K.T., and H.S. conducted the in vitro and
behavioral tests. S.K. and K.N. obtained funding. K.N. and S.K. supervised the study. M.S., K.N., and S.K. edited
the manuscript.
Competing interests M.S. is an employee of Medical Database Ltd. The other authors declare no competing interests.
Additional information
Supplementary Information The online version contains supplementary material available at https://doi.
org/10.1038/s41598-020-80113-7.
Correspondence and requests for materials should be addressed to K.N. or S.K.
Reprints and permissions information is available at www.nature.com/reprints.
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