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大学・研究所にある論文を検索できる 「Periosteal expansion osteogenesis using an innovative, shape-memory polyethylene terephthalate (PET) membrane: An experimental study in rabbits」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。
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Periosteal expansion osteogenesis using an innovative, shape-memory polyethylene terephthalate (PET) membrane: An experimental study in rabbits

井本 和宏 東北大学

2021.03.25

概要

Background: Periosteal expansion osteogenesis (PEO) results in the formation of new bone in the gap between periosteum and original bone. The purpose of this study is to evaluate the use of a polyethylene terephthalate (PET) membrane as an activation device.

Methods: A dome-shaped PET membrane coated with hydroxyapatite (HA) /gelatin on the inner side was inserted between the elevated periosteum and bone at the rabbit calvaria. In the experimental group, the membrane was pushed, bent, and attached to the bone surface and fixed with a titanium screw. In control group, the membrane was only inserted and fixed with titanium screw at original shape under the periosteum. After 7 days, the screw was removed and the mesh was activated in the experimental group. Three animals per group with or without setting a latency period for activation were sacrificed at 3 and 5 weeks after surgery. Bone formation was evaluated via micro-computed tomography and determined by histomorphometric methods and histological evaluation.

Results: No PET membrane-associated complications were observed during this study. The quantitative data by the area and the occupation of newly formed bone indicated that the experimental group had a higher volume of new bone than the control group at 3 weeks after surgery. Histologically, bone formation progressed to areas adjacent to the cortical perforations; many sinusoidal vessels ran from the perforations to overlying fibrous tissue via the new bone. No bone or obvious inflammatory cells were observed over the membrane.

Conclusion: The PET membrane has biocompatible device for PEO that induces a natural osteogenic response at the gap between the original bone and periosteum.

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