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大学・研究所にある論文を検索できる 「Locoregional recurrence via mucus-mediated extension following lung resection for mucinous tumors.」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

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Locoregional recurrence via mucus-mediated extension following lung resection for mucinous tumors.

KAWAGUCHI Yo 0000-0002-7828-4635 HANAOKA Jun 00452243 0000-0002-5272-556X OHSHIO Yasuhiko 60731916 OKAMOTO Keigo 000-0002-6992-3765 KAKU Ryosuke HAYASHI Kazuki 0000-0002-2393-1233 SHIRATORI Takuya AKAZAWA Akira ISHIDA Mitsuaki 00464173 滋賀医科大学

2021.04.27

概要

Background:
Clinically, locoregional recurrences following mucinous tumor resection are often experienced. However, it remains unclear whether mucinous tumors directly affect local recurrence or not, and if so, the mechanism is not known. Therefore, we investigated whether mucinous tumors are associated with locoregional recurrence after pulmonary resection and whether mucus extension is a risk factor for locoregional recurrence.
Methods:
The data of 152 patients who underwent pulmonary resection for metastases were reviewed. When mucus was partially or wholly present in the tumor based on macro- or microscopic identification, we assigned the tumor as mucinous. In mucinous tumors, when mucus was identified within the air spaces in the normal lung parenchyma, beyond the edge of the tumor, we assigned the tumor as positive for "mucus extension."
Results:
The 5-year cumulative incidence of locoregional recurrence in patients with mucinous tumors was 48.1%, which was significantly higher than that observed in those with non-mucinous tumors (14.9%). Within the mucinous tumor, the presence of mucus extension beyond the tumor edge was an independent risk factor for locoregional recurrence after pulmonary resection (hazard ratio, 5.52; P = 0.019).
Conclusions:
During the resection of mucinous cancer, surgeons should maintain sufficient distance from the tumor edge to prevent locoregional recurrences.

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