1. Mager, D. L. & Stoye, J. P. Mammalian endogenous retroviruses. Microbiol. Spectr. https://d
oi.o
rg/1 0.1 128/m
icrob
iolsp
ec.M
DNA3-
0009-2014 (2015).
2. Hussain, A. I., Johnson, J. A., Da Silva Freire, M. & Heneine, W. Identification and characterization of avian retroviruses in chicken
embryo-derived yellow fever vaccines: Investigation of transmission to vaccine recipients. J. Virol. 77, 1105–1111. https://doi.org/
10.1128/jvi.77.2.1105-1111.2003 (2003).
3. Tsang, S. X. et al. Evidence of avian leukosis virus subgroup E and endogenous avian virus in measles and mumps vaccines derived
from chicken cells: Investigation of transmission to vaccine recipients. J. Virol. 73, 5843–5851. https://doi.org/10.1128/JVI.73.7.
5843-5851.1999 (1999).
4. Miyazawa, T. Endogenous retroviruses as potential hazards for vaccines. Biologicals 38, 371–376. https://doi.org/10.1016/j.biolo
gicals.2010.03.003 (2010).
5. Miyazawa, T. et al. Isolation of an infectious endogenous retrovirus in a proportion of live attenuated vaccines for pets. J. Virol.
84, 3690–3694. https://doi.org/10.1128/JVI.02715-09 (2010).
6. Yoshikawa, R., Sato, E., Igarashi, T. & Miyazawa, T. Characterization of RD-114 virus isolated from a commercial canine vaccine
manufactured using CRFK cells. J. Clin. Microbiol. 48, 3366–3369. https://doi.org/10.1128/JCM.00992-10 (2010).
7. Yoshikawa, R., Sato, E. & Miyazawa, T. Contamination of infectious RD-114 virus in vaccines produced using non-feline cell lines.
Biologicals 39, 33–37. https://doi.org/10.1016/j.biologicals.2010.11.001 (2011).
8. Yoshikawa, R., Sato, E. & Miyazawa, T. Presence of infectious RD-114 virus in a proportion of canine parvovirus isolates. J. Vet.
Med. Sci. 74, 347–350. https://doi.org/10.1292/jvms.11-0219 (2012).
9. Reeves, R. H. & O’Brien, S. J. Molecular genetic characterization of the RD-114 gene family of endogenous feline retroviral
sequences. J. Virol. 52, 164–171. https://doi.org/10.1128/JVI.52.1.164-171.1984 (1984).
10. Baumann, J. G., Gunzburg, W. H. & Salmons, B. CrFK feline kidney cells produce an RD114-like endogenous virus that can package murine leukemia virus-based vectors. J. Virol. 72, 7685–7687. https://doi.org/10.1128/JVI.72.9.7685-7687.1998 (1998).
11. Weiss, R. A. The discovery of endogenous retroviruses. Retrovirology 3, 67. https://doi.org/10.1186/1742-4690-3-67 (2006).
12. Fischinger, P. J., Peebles, P. T., Nomura, S. & Haapala, D. K. Isolation of RD-114-like oncornavirus from a cat cell line. J. Virol. 11,
978–985. https://doi.org/10.1128/JVI.11.6.978-985.1973 (1973).
Scientific Reports |
Vol:.(1234567890)
(2022) 12:6641 |
https://doi.org/10.1038/s41598-022-10497-1
www.nature.com/scientificreports/
A Self-archived copy in
Kyoto University Research Information Repository
https://repository.kulib.kyoto-u.ac.jp
13. Teich, N. 2 Taxonomy of retroviruses. Cold Spring Harb. Monogr. Arch. 10, 25–207 (1982).
14. Okada, M., Yoshikawa, R., Shojima, T., Baba, K. & Miyazawa, T. Susceptibility and production of a feline endogenous retrovirus
(RD-114 virus) in various feline cell lines. Virus Res. 155, 268–273. https://doi.org/10.1016/j.virusres.2010.10.020 (2011).
15. Dunn, K. J., Yuan, C. C. & Blair, D. G. A phenotypic host range alteration determines RD114 virus restriction in feline embryonic
cells. J. Virol. 67, 4704–4711. https://doi.org/10.1128/JVI.67.8.4704-4711.1993 (1993).
16. Shimode, S., Nakaoka, R., Shogen, H. & Miyazawa, T. Characterization of feline ASCT1 and ASCT2 as RD-114 virus receptor. J.
Gen. Virol. 94, 1608–1612. https://doi.org/10.1099/vir.0.052928-0 (2013).
17. Hartley, J. W., Wolford, N. K., Old, L. J. & Rowe, W. P. A new class of murine leukemia virus associated with development of
spontaneous lymphomas. Proc. Natl. Acad. Sci. USA 74, 789–792. https://doi.org/10.1073/pnas.74.2.789 (1977).
18. McGrath, M. S. & Weissman, I. L. AKR leukemogenesis: Identification and biological significance of thymic lymphoma receptors
for AKR retroviruses. Cell 17, 65–75. https://doi.org/10.1016/0092-8674(79)90295-2 (1979).
19. Young, G. R. et al. Resurrection of endogenous retroviruses in antibody-deficient mice. Nature 491, 774–778. https://doi.org/10.
1038/nature11599 (2012).
20. Yu, P. et al. Nucleic acid-sensing Toll-like receptors are essential for the control of endogenous retrovirus viremia and ERV-induced
tumors. Immunity 37, 867–879. https://doi.org/10.1016/j.immuni.2012.07.018 (2012).
21. Niman, H. L., Stephenson, J. R., Gardner, M. B. & Roy-Burman, P. RD-114 and feline leukaemia virus genome expression in natural
lymphomas of domestic cats. Nature 266, 357–360. https://doi.org/10.1038/266357a0 (1977).
22. Niman, H. L., Gardner, M. B., Stephenson, J. R. & Roy-Burman, P. Endogenous RD-114 virus genome expression in malignant
tissues of domestic cats. J. Virol. 23, 578–586. https://doi.org/10.1128/jvi.23.3.578-586.1977 (1977).
23. Yoshikawa, R., Yasuda, J., Kobayashi, T. & Miyazawa, T. Canine ASCT1 and ASCT2 are functional receptors for RD-114 virus in
dogs. J. Gen. Virol. 93, 603–607. https://doi.org/10.1099/vir.0.036228-0 (2012).
24. Ochiai, H. et al. cDNA sequence and tissue distribution of canine Na-dependent neutral amino acid transporter 2 (ASCT 2). J.
Vet. Med. Sci. 74, 1505–1510. https://doi.org/10.1292/jvms.12-0171 (2012).
25. Reeves, R. H., Nash, W. G. & O’Brien, S. J. Genetic mapping of endogenous RD-114 retroviral sequences of domestic cats. J. Virol.
56, 303–306. https://doi.org/10.1128/JVI.56.1.303-306.1985 (1985).
26. Shimode, S., Nakagawa, S. & Miyazawa, T. Multiple invasions of an infectious retrovirus in cat genomes. Sci. Rep. 5, 8164. https://
doi.org/10.1038/srep08164 (2015).
27. Joung, J. K. & Sander, J. D. TALENs: A widely applicable technology for targeted genome editing. Nat. Rev. Mol. Cell Biol. 14, 49–55.
https://doi.org/10.1038/nrm3486 (2013).
28. Sander, J. D. & Joung, J. K. CRISPR-Cas systems for editing, regulating and targeting genomes. Nat. Biotechnol. 32, 347–355. https://
doi.org/10.1038/nbt.2842 (2014).
29. Zhang, X. H., Tee, L. Y., Wang, X. G., Huang, Q. S. & Yang, S. H. Off-target effects in CRISPR/Cas9-mediated genome engineering.
Mol. Ther. Nucl. Acids 4, e264. https://doi.org/10.1038/mtna.2015.37 (2015).
30. Sakuma, T. et al. Repeating pattern of non-RVD variations in DNA-binding modules enhances TALEN activity. Sci. Rep. 3, 3379.
https://doi.org/10.1038/srep03379 (2013).
31. Sakuma, T. & Woltjen, K. Nuclease-mediated genome editing: At the front-line of functional genomics technology. Dev. Growth
Differ. 56, 2–13. https://doi.org/10.1111/dgd.12111 (2014).
32. Guschin, D. Y. et al. A rapid and general assay for monitoring endogenous gene modification. Methods Mol. Biol. 649, 247–256.
https://doi.org/10.1007/978-1-60761-753-2_15 (2010).
33. Victoria, J. G. et al. Viral nucleic acids in live-attenuated vaccines: Detection of minority variants and an adventitious virus. J. Virol.
84, 6033–6040. https://doi.org/10.1128/JVI.02690-09 (2010).
34. Yang, L. et al. Genome-wide inactivation of porcine endogenous retroviruses (PERVs). Science 350, 1101–1104. https://doi.org/
10.1126/science.aad1191 (2015).
35. Niu, D. et al. Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9. Science 357, 1303–1307. https://doi.org/
10.1126/science.aan4187 (2017).
36. McDougall, A. S. et al. Defective endogenous proviruses are expressed in feline lymphoid cells: Evidence for a role in natural
resistance to subgroup B feline leukemia viruses. J. Virol. 68, 2151–2160. https://doi.org/10.1128/JVI.68.4.2151-2160.1994 (1994).
37. Jarrett, O. & Ganiere, J. P. Comparative studies of the efficacy of a recombinant feline leukaemia virus vaccine. Vet. Rec. 138, 7–11.
https://doi.org/10.1136/vr.138.1.7 (1996).
38. Theilen, G. H., Kawakami, T. G., Rush, J. D. & Munn, R. J. Replication of cat leukemia virus in cell suspension cultures. Nature
222, 589–590. https://doi.org/10.1038/222589b0 (1969).
39. Sakaguchi, S. et al. Focus assay on RD114 virus in QN10S cells. J. Vet. Med. Sci. 70, 1383–1386. https://doi.org/10.1292/jvms.70.
1383 (2008).
40. Hamano, M. et al. Experimental infection of recent field isolates of feline herpesvirus type 1. J. Vet. Med. Sci. 65, 939–943. https://
doi.org/10.1292/jvms.65.939 (2003).
41. Miyazawa, T. et al. Isolation of feline parvovirus from peripheral blood mononuclear cells of cats in northern Vietnam. Microbiol.
Immunol. 43, 609–612. https://doi.org/10.1111/j.1348-0421.1999.tb02447.x (1999).
42. Makino, A. et al. Junctional adhesion molecule 1 is a functional receptor for feline calicivirus. J. Virol. 80, 4482–4490. https://doi.
org/10.1128/JVI.80.9.4482-4490.2006 (2006).
43. Ikeda, Y. et al. New quantitative methods for detection of feline parvovirus (FPV) and virus neutralizing antibody against FPV
using a feline T lymphoid cell line. J. Vet. Med. Sci. 60, 973–974. https://doi.org/10.1292/jvms.60.973 (1998).
44. Sassa, Y., Fukui, D., Takeshi, K. & Miyazawa, T. Neutralizing antibodies against feline parvoviruses in nondomestic felids inoculated
with commercial inactivated polyvalent vaccines. J. Vet. Med. Sci. 68, 1195–1198. https://doi.org/10.1292/jvms.68.1195 (2006).
45. Doyle, E. L. et al. TAL effector-nucleotide targeter (TALE-NT) 2.0: Tools for TAL effector design and target prediction. Nucleic
Acids Res. 40, W117-122. https://doi.org/10.1093/nar/gks608 (2012).
Acknowledgements
We are grateful to Prof. O. Jarrett (Glasgow University, Glasgow, U.K.) for providing QN10S cells. This work
was supported by JSPS KAKENHI [Grant Numbers JP16K21129, JP20K15692, JP20H03150, and JP22K06043].
Author contributions
S.S. and T.M. designed the experiments. S.S. performed the experiments. T.S. and T.Y. designed and prepared
TALEN constructs. S.S., T.M., T.S., and T.Y. wrote the manuscript. All authors read and approved the final
manuscript.
Competing interests The authors declare no competing interests.
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