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MrgprB4 in trigeminal neurons expressing TRPA1 modulates unpleasant sensations

Tobori, Shota Hiyama, Haruka Miyake, Takahito Yano, Yuichi Nagayasu, Kazuki Shirakawa, Hisashi Nakagawa, Takayuki Mori, Yasuo Kaneko, Shuji 京都大学 DOI:10.1016/j.jphs.2021.04.006

2021.08

概要

Gentle touch such as stroking of the skin produces a pleasant feeling, which is detected by a rare subset of sensory neurons that express Mas-related G protein-coupled receptor B4 (MrgprB4) in mice. We examined small populations of MrgprB4-positive neurons in the trigeminal ganglion and the dorsal root ganglion, and most of these were sensitive to transient receptor potential ankyrin 1 (TRPA1) agonist but not TRPV1, TRPM8, or TRPV4 agonists. Deficiency of MrgprB4 did not affect noxious pain or itch behaviors in the hairless plantar and hairy cheek. Although behavior related to acetone-induced cold sensing in the hind paw was not changed, unpleasant sensory behaviors in response to acetone application or sucrose splash to the cheek were significantly enhanced in Mrgprb4-knockout mice as well as in TRPA1-knockout mice. These results suggest that MrgprB4 in the trigeminal neurons produces pleasant sensations in cooperation with TRPA1, rather than noxious or cold sensations. Pleasant sensations may modulate unpleasant sensations on the cheek via MrgprB4.

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参考文献

1. Vriens J, Nilius B, Voets T. Peripheral thermosensation in mammals. Nat Rev

Neurosci. 2014;15:573e589. https://doi.org/10.1038/nrn3784.

2. LaMotte RH, Dong X, Ringkamp M. Sensory neurons and circuits mediating itch.

Nat Rev Neurosci. 2014;15:19e31. https://doi.org/10.1038/nrn3641.

3. Katta S, Krieg M, Goodman MB. Feeling force: physical and physiological

principles enabling sensory mechanotransduction. Annu Rev Cell Dev Biol.

2015;31:347e371. https://doi.org/10.1146/annurev-cellbio-100913-013426.

rez S. Ion channels and thermosensitivity:

4. Lamas JA, Rueda-Ruzafa L, Herrera-Pe

TRP, TREK, or both? Int J Mol Sci. 2019;20:2371. https://doi.org/10.3390/

ijms20102371.

5. Talavera K, Startek JB, Alvarez-Collazo J, et al. Mammalian transient receptor

potential TRPA1 channels: from structure to disease. Physiol Rev. 2020;100:

725e803. https://doi.org/10.1152/physrev.00005.2019.

6. Story GM, Peier AM, Reeve AJ, et al. ANKTM1, a TRP-like channel expressed in

nociceptive neurons, is activated by cold temperatures. Cell. 2003;112:

819e829. https://doi.org/10.1016/s0092-8674(03)00158-2.

~ overos J, Holt JR, et al. TRPA1 is a candidate for the

7. Corey DP, García-An

mechanosensitive transduction channel of vertebrate hair cells. Nature.

2004;432:723e730. https://doi.org/10.1038/nature03066.

8. Kwan KY, Allchorne AJ, Vollrath MA, et al. TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron. 2006;50:277e289. https://doi.org/10.1016/j.neuron.2006.03.

042.

9. Bautista DM, Jordt SE, Nikai T, et al. TRPA1 mediates the inflammatory actions

of environmental irritants and proalgesic agents. Cell. 2006;124:1269e1282.

https://doi.org/10.1016/j.cell.2006.02.023.

10. Karashima Y, Talavera K, Everaerts W, et al. TRPA1 acts as a cold sensor in vitro

and in vivo. Proc Natl Acad Sci U S A. 2009;106:1273e1278. https://doi.org/

10.1073/pnas.0808487106.

11. Zappia KJ, O'Hara CL, Moehring F, Kwan KY, Stucky CL. Sensory neuron-specific

deletion of TRPA1 results in mechanical cutaneous sensory deficits. eNeuro.

2017;4. https://doi.org/10.1523/ENEURO.0069-16.2017. ENEURO.0069-16.2017.

12. Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ. A diverse family of GPCRs

expressed in specific subsets of nociceptive sensory neurons. Cell. 2001;106:

619e632. https://doi.org/10.1016/s0092-8674(01)00483-4.

13. Bader M, Alenina N, Andrade-Navarro MA, Santos RA. MAS and its related G

protein-coupled receptors. Mrgprs Pharmacol Rev. 2014;66:1080e1105.

https://doi.org/10.1124/pr.113.008136.

14. Liu Q, Tang Z, Surdenikova L, et al. Sensory neuron-specific GPCR Mrgprs are

itch receptors mediating chloroquine-induced pruritus. Cell. 2009;139:

1353e1365. https://doi.org/10.1016/j.cell.2009.11.034.

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